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TLK Model Sample Input File: Radiosensitivity parameters correspond to an alpha/beta ratio of 3.61 Gy. DSB repair is biphasic (fast repair half-time = 0.25 h, slow repair half-time = 7 hour). The entire cell population is in a non-dividing (quiescent) state, i.e., GF=0.
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MODEL: DRM=TLK CKM=QECK !Model Specification
CELL: DNA=5.667D+09 NC=46
IRAD: DSB=25 FCB=0.2
CLRP: RHT=HT4R ETA=2.00E-04 PHI=0.01 A0=AAA GAM=0.25
CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1
RBM: KX=6.0E+06 FMAX=1 !Analysis of PFGE data
! TLK model inputs (simple and complex double strand breaks)
HT4R = 0.25 7 / !Half-times for DSB repair
AAA = 0.95 0.25 / !Probability DSB is rejoined correctly
! Parameters that impact on solution accuracy
SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10
! Parameters that control the time steps and stopping criteria
SIMCON: FSDX=1 TSAX=5 TCUT=100 FRDL=1.0D+00 RCUT=1.0D-09
! Method 3: Dose rate and exposure time
RADX: ADR=20 DOX=0.2