Syntax:
CLRP: PHI={probability a misrejoined DSB is lethal}
Example:
CLRP: PHI=0.025 !RMR and TLK model; Not used in LPL model (see IRAD: FL parameter)
Purpose: Set the probability a misrejoined DSB is lethal
Data Type: real number
Unit: n/a
Default: 0.005 (0.5% of misrejoined DSBs are lethal)
Comments: Misrejoined DSBs can either be lethal or non-lethal. The PHI parameter determines the fraction of the misrejoined DSBs that are lethal. The fraction of the misrejoined DSBs that are non-lethal is (1-PHI). The A0 (or B0) parameter determines the probability that the fraction of the DSBs that are converted into lethal or non-lethal genetic alterations (i.e., a mutation). The type of repair mechanism (NHEJ or HR) determines the probability a DSB is converted into a mutation. The fraction of these mutations that are lethal is mainly determined by the initial location of the DSB along the chromosome (e.g., did the DSB occur in a critical housekeeping gene?).
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