- Radiation delivery: Figures and discussion related to the quantification of time varying radiation fields. Examples illustrate irradiation schemes commonly used in laboratory experiments and in radiation therapy for the treatment of cancer.
- DSB rejoining kinetics: Comparisons of measured and predicted double strand break (DSB) rejoining kinetics for various cell lines and exposure conditions. Examples of the expected number of DSB cell-1 as a function of time during and after irradiation.
- Mutagenesis: Examples of the predicted rate at which lethal and non-lethal mutations accumulate as a function of time during and after irradiation.
- Surviving fraction: Comparisons of measured and predicted cell survival data for single fraction and split-dose exposure conditions. Examples of the predicted surviving fraction, with and without corrections for repopulation effects, as a function of time during and after irradiation.
- Cell and tumor kinetics: Comparisons of measured and predicted growth kinetics for cells, multicell spheroids, and tumors. Examples include tumor growth kinetics during and after external beam and brachytherapy radiation therapy treatments.
- Neoplastic transformation: Comparisons of measured and predicted data for the neoplastic transformation frequency. Examples of the predicted transformation frequency with and without the spontaneous (background) transformation.
- Radiation therapy treatment planning: Examples of the predicted tumor control probabilities (TCP) and related quantities (e.g., normalized isoeffective dose) for various multi-fraction and brachytherapy irradiation schemes with and without corrections for repopulation effects.
Tip: Radioactive materials emit photons, electrons, neutrons and other ionizing particles. The deposition of energy inside the human body or a cell depends on many factors, including the type of radiation and the initial kinetic energy of the particle. The Virtual Cell does not perform the radiation dosimetry calculations required to convert an estimate of the intensity of ionizing particles at some location in space (i.e., the particle fluence rate) into an estimate of the instantaneous absorbed dose rate (Gy/s or Gy/h). Other widely available computer codes, such as PENELOPE and EGSnrc, can be used to perform so-called fluence-to-dose calculations.
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