Principal Investigator: R.D. Stewart, Ph.D.
|The Virtual Cell (VC) represents an ongoing effort to construct a useful, multiscale system of models to simulate early events and processes involved in the pathogenesis and treatment of cancer. The main biological endpoints of interest in the VC are cell death and neoplastic transformation. The VC also provides information about the formation and repair of DNA damage and some information about chromosome aberration yields, the induction of genomic instability, cell cycle kinetics, and the probability of tumor eradication following radiation therapy.|
Motivation: Mechanism-based modeling of biological systems may help reduce uncertainties in the estimated (putative) health risks of low doses of ionizing radiation and contribute to the optimization of radiation therapy for the treatment of cancer.
|The Virtual Cell software development effort is supported by the U.S. Department of Energy's Low Dose Radiation Research Program through the Office of Science (BER), Grants DE-FG02-03ER63541 and DE-FG02-03ER63665 (R.D. Stewart, Principal Investigator).|
|School of Health Sciences|
Last updated: 10 June, 2011