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Principal Investigator: R.D. Stewart, Ph.D.
Version 1.1 is available at  Contact Dr. R.D. Stewart ( to obtain a beta distribution of VC Version 2.  Features new in Version 2.0 include:
  • Models are included to track the formation and repair of 102 distinct classes of DNA damage (2 kinds of DSB, 100 other kinds of singly or multiply damaged DNA site).
  • Pathway-specific DNA repair models (base and nucleotide excision repair) for singly and multiply damaged DNA sites other than the DSB.
  • The MCDS and MCER algorithms are used to generate DNA damage configurations and repair data for low- and high-LET radiation.
  • Improved non-linear parameter estimation capabilities, e.g., estimate parameters using PFGE data (DSB formation and rejoining), cell survival and neoplastic transformation.
  • New capabilities for the prediction LET effects, oxygen effects and repopulation effects.
  • Calculation of tumor control probabilities (TCP), normalized isoeffective dose (NID), biologically equivalent dose (BED), LQ parameters, and much more…

School of Health Sciences
Purdue University

Last updated: 10 June, 2011