2000 2001200220032004200520062007200820092010 2011 201220132014201520162017


1. Scott, J. D. and Fothergill, J. E.  (1982).  A general method for affinity purification of complement component C3b using factor H-sepharose.  Biochemical Journal 205:575-580. PMCID: PMC1158523 [pdf]


2. Scott, J. D., Dunbar, B. and Fothergill, J. E.  (1983).  The structural characterization of fragments produced by inactivation of the third component of complement by Factor I.  Immunobiology 164:240-241.


3. Scott, J.D., Fischer, E.H., Demaille, J.G. and Krebs, E.G.  (1985).  Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase.  Proceedings of the National Academy of Sciences USA 82:4379-4383. PMCID: PMC391417 [pdf]

4. Scott, J. D., Fischer, E. H., Takio, K., Demaille, J. G. and Krebs, E. G.  (1985).  Amino acid sequence of the heat-stable inhibitor of the cAMP-dependent protein kinase from rabbit skeletal muscle. Proceedings of the National Academy of Sciences USA 82:5732-5736. PMCID: PMC390626 [pdf]

5. Ballou, L.A., Villa-Moruzzi, E., McNall, S. J., Scott, J. D., Blumenthal, D. K., Krebs, E. G. and Fischer, E. H.  (1985).  Structure, properties and regulation of phosphorylase phosphatase.  Advances in Protein Phosphatases 1:21-27.


6. Scott, J. D., Glaccum, M. A., Fischer, E. H. and Krebs, E. G.  (1986).  Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase.  Proceedings of the National Academy of Sciences USA 83:1613-1616. PMCID: PMC323133 [pdf]

7. Malencik, D., Scott, J. D., Fischer, E. H., Krebs, E. G. and Anderson, S. A. (1986). Association of calmodulin with peptide analogues of the inhibitory region of the heat-stable protein inhibitor of adenosine cyclic 3',5'-phosphate dependent protein kinase.  Biochemistry 25:3502-3508.


8. Toda, T., Cameron, S., Sass, P., Zoller, M., Scott, J. D., McMullen, B., Hurwitz, M.D., Krebs, E. G. and Wigler, M.  (1987).  Cloning and characterization of BCY1 a locus encoding the regulatory subunit of the cAMP-dependent protein kinase in Saccharomyces cerevisiae.  Journal for Molecular and Cellular Biology 7:137l-1377. PMCID: PMC2365223 [pdf]

9. Scott, J. D., Glaccum, M. B., Zoller, M., Uhler, M.D., Helfman, D. M., McKnight, G. S. and Krebs, E. G. (1987).  The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain.  Proceedings of the National Academy of Sciences USA 84:5192-5196. PMCID: PMC298820 [pdf]

10.Kennelly, P. J., Takio, K., Blumenthal, D. K., Edelman, A. M., Glaccum, M. B., Klevit, R. E., Roush, C. L., Scott, J. D., Titani, K., Walsh, K. A. and Krebs, E. G.  (1987).  Organization of myosin light chain kinase from rabbit skeletal muscle.  Proceedings of the 5th International Symposium on Calcium Binding Proteins.  Calcium-Binding Proteins in Health and Disease 494-504.


11. Roush, C.L., Kennelly, P. J., Glaccum, M. B., Helfman, D.M., Scott, J. D. and Krebs, E. G.  (1988). Isolation of the cDNA encoding rat skeletal muscle myosin light chain kinase:  sequence and tissue distribution.  Journal of Biological Chemistry 263:10510-10516. [pdf]

12. Oyen, O., Scott, J.D., Cadd, G.G., McKnight, G.S., Krebs, E.G., Hansson, V. and Jahnsen, T.  (1988). A unique mRNA species for a regulatory subunit of cAMP-dependent protein kinase is specifically induced in haploid germ cells.  FEBS Letters 229:391-394. [pdf]


13. Oyen, O., Myklebust, F., Scott, J.D., Hansson, V. and Jahnsen, T.  (l989).  Human testis cDNA for the regulatory subunit RIIa of cAMP-dependent protein kinase encodes an alternate amino-terminal region.  FEBS Letters 246:57-64. [pdf]

14. Ekanger, R., Vintermyr, O.K., Houge, G., Sand, T.E., Scott, J.D., Krebs, E.G., Eikhom, T.S., Christoffersen, T., Ogreid, D. and Doskeland, S.O.  (l989).  The expression of cAMP-dependent protein kinase subunits is differentially regulated during liver regeneration.  Journal of Biological Chemistry 264:4374-4389. [pdf]

back to top


15. Oyen, O., Myklebust, F., Scott, J.D., Cadd, G.G., McKnight, G.S., Hansson, V. and Jahnsen, T.  (l990).  Subunits of cAMP-dependent protein kinase show differential and distinct expression patterns during germ cell differentiation - alternative polyadenylation in germ cells gives rise to unique smaller-sized mRNA species.  Biology of Reproduction 43:46-54. [pdf]

16. Ludvig, N., Ribak, C.E., Scott, J.D. and Rubin, C.S.  (l990).  Immunocytochemical localization of the type II cyclic AMP-dependent protein kinase to postsynaptic structures in the rat brain.  Brain Research 520:90-102. [pdf]

17. Scott, J.D., Stofko, R.E., MacDonald, J.R., Comer, J.D., Vitalis, E.A. and Mangeli, J.  (1990).  Type II regulatory subunit dimerization determines the subcellular location of the cAMP-dependent protein kinase.  Journal of Biological Chemistry 265:21561-21566. [pdf]


18. Wang, Y., Scott, J.D., McKnight, G.S. and Krebs, E.G.  (1991).  A constitutively active holoenzyme form of the cAMP-dependent protein kinase.  Proceedings of the National Academy of Sciences USA 88:2446-2450. [pdf]

19. Carr, D.W., Stofko, R.E., Fraser, I.D.C. Bishop, S.M., Acott, T.S., Brennan, R.G. and Scott, J.D. (1991).  Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif.  Journal of Biological Chemistry 266:14188-14192. [pdf]

20. Scott, J.D.  (1991).  Cyclic nucleotide-dependent protein kinases.  Review.  In: Pharmacology and Therapeutics 50:123-145. [pdf]

21. Machida, C.M., Scott, J.D. and Ciment, G.  (1991).  NGF-induction of the metalloproteinase transin/stromelysin in PC12 cells:  involvement of multiple protein kinases.  Journal of Cellular Biology 114:1037-1048. [pdf]


22. Scott, J.D. and Carr, D.W.  (1992).  Subcellular localization of the type II cAMP-dependent protein kinase.  News in Physiological Sciences 7:143-148. [pdf]

23. Stofko-Hahn, R.E., Carr, D.W. and Scott, J.D.  (1992).  A single step purification for recombinant proteins.  Characterization of a microtubule associated protein (MAP2) fragment which associates with the type II cAMP-dependent protein kinase.  FEBS Letters 302:274-278. [pdf]

24. Carr, D.W., Hausken, Z.E., Fraser, I.D.C., Stofko-Hahn, R.E. and Scott, J.D.  (1992).  Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein.  Cloning and characterization of the RII-binding domain.  Journal of Biological Chemistry 267:13376-13382. [pdf]

25. Carr, D.W. and Scott, J.D.  (1992).  Blotting and band-shifting:  techniques for studying protein-protein interactions.  TIBS 17:246-251. [pdf]

26. Scott, J.D. and Soderling, T.R.  (1992).  Serine/threonine protein kinases.  Current Opinion in Neurobiology 2:289-295.

27. Carr, D.W., Stofko-Hahn, R.E., Fraser, I.D.C., Cone, R.D. and Scott, J.D.  (1992).  Localization of the cAMP-dependent protein kinase to the post synaptic density by A-kinase anchoring proteins: characterization of AKAP79.  Journal of Biological Chemistry 267:16816-16823. [pdf]


28. Scott, J.D.  (1993).  Cyclic nucleotide-dependent protein kinases.  Review.  In: Encyclopedia of Pharmacology and Therapeutics 139:137-156.

29. Carr, D.W., DeManno, D.A., Atwood, A., Hunzicker-Dunn, M. and Scott, J.D.  (1993).  Follicle-stimulating hormone regulation of A-kinase anchoring protein in granulosa cells.  Journal of Biological Chemistry 268:20729-20732. [pdf]

30. Coghlan, V.M., Bergeson, S.E., Langeberg, L.K., Nilaver, G. and Scott, J.D.  (1993).  A-kinase anchoring proteins:  a key to selective activation of cAMP-responsive events?  Molecular and Cellular Biochemistry 127:309-321.


31. Scott, J.D. and McCartney, S.  (1994).  Localization of A-kinase through anchoring proteins.  Molecular Endocrinology 8:5-11.

32. Cheley, S., Panchal, R.G., Carr, D.W., Scott, J.D. and Bayley, H.  (1994).  Type II regulatory subunits of cAMP-dependent protein kinase and their binding proteins in the nervous system of Aplysia californica.  Journal of Biological Chemistry 269:2911-2920. [pdf]

33. Coghlan, V.M., Langeberg, L.K., Fernandez, A., Lamb, N. J. C. and Scott, J.D.  (1994).  Cloning and characterization of AKAP 95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase.  Journal of Biological Chemistry 269:7658-7665. [pdf]

34. Rosenmund, C., Carr D.W., Bergeson S.E., Nilaver, G., Scott, J.D. and Westbrook, G.L.  (1994).  Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons.  Nature 368:853-856. [pdf]

35. Hausken, Z.E., Coghlan, V.M., Schafer Hastings, C.A., Reimann, E.M. and Scott, J.D.  (1994).  Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5.  Journal of Biological Chemistry 269:24245-24251. [pdf]

36. Solberg, R., Tasken, K., Wen, W., Coghlan, V., Meinkoth, J.L., Scott, J.D., Jahnsen, T. and Taylor, S.S.  (1994).  Human regulatory subunit RIß of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells.  Experimental Cell Research 214:595-605. [pdf]


37. Coghlan, V.M., Perrino, B.A., Howard, M., Langeberg, L.K., Hicks, J.B., Gallatin, W.M. and Scott, J.D. (1995).  Association of protein kinase A and protein phosphatase 2B with a common anchoring protein.  Science 267:108-112. [pdf]

38. McCartney, S., Little B.M., Langeberg, L.K. and Scott, J.D.  (1995).  Cloning and characterization of A-kinase anchor protein 100 (AKAP100):  a protein that targets A-kinase to the sarcoplasmic reticulum.  Journal of Biological Chemistry 270:9327-9333. [pdf]

39. McCartney S, Little BM, Scott JD. (1995) Analysis of a novel A-kinase anchoring protein 100, (AKAP 100). Biochem Soc Trans.23(2):268S. [pdf]

40. Coghlan, V.M., Lester, L. and Scott, J.D.  (1995).  A targeting model for reversible phosphorylation. Advances in Protein Phosphatases 9:51-61.

41. Coghlan, V.M., Hausken, Z.E. and Scott, J.D.  (1995).  Subcellular targeting of kinases and phosphatases by association with bifunctional anchoring proteins.  Biochemical Society Transactions 23:592-595. [pdf]

42. Klauck, T.M. and Scott, J. D. (1995).  The postsynaptic density:  a subcellular anchor for signal transduction enzymes.  Cellular Signaling 7:747-757. [pdf]

back to top


43. Klauck, T.M., Faux, M.C., Labudda, K., Langeberg, L.K., Jaken, S. and Scott, J.D.  (1996). Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein.  Science 271:1589-1592. [pdf]

44. Faux, M.C., and Scott, J.D. (1996). Molecular glue: kinase anchoring and scaffold proteins: conferring specificity by location.  Cell 85:9-12. [pdf]

45. Lester, L.B., Coghlan, V.M., Nauert, B. and Scott J.D.  (1996).  Cloning and characterization of a novel A-kinase anchoring protein:  AKAP 220 association with testicular peroxisomes.  Journal of Biological Chemistry 271:9460-9465. [pdf]

46. Faux, M.C. and Scott, J.D.  (1996).  More on target with protein phosphorylation.  TIBS 21:312-315. [pdf]

47. Hausken, Z.E. and Scott, J.D.  (1996).  Properties of A-kinase anchoring proteins.  Biochemical Society Transactions 24:986-991.

48. Zhang, Q., Carr, D.W., Lerea, K.M., Scott, J.D. and Newman, S.A.  (1996).  Nuclear localization of type II cAMP-dependent protein kinase during limb cartilage differentiation is associated with a novel developmentally regulated A-kinase anchoring protein.  Developmental Biology 176:51-61. [pdf]

49. Hausken, Z.E., Dell’Acqua, M.L., Coghlan, V.M. and Scott, J.D.  (1996).  Mutational analysis of the AKAP-binding site on RII:  classification of side-chain determinants for anchoring and isoform selective association with AKAPs.  Journal of Biological Chemistry 271:29016-29022. [pdf]


50. Nauert, J.B., Klauck, T.M., Langeberg, L.K. and Scott, J.D.  (1997).  Gravin: an autoantigen recognized by myasthenia gravis sera is a kinase scaffold protein.  Current Biology 7:52-67. [pdf]

51. Dell’Acqua, M.L. and Scott, J.D.  (1997).  Protein kinase A anchoring.  Journal of Biological Chemistry 272:12881-12884. [pdf]

52. Scott, J.D.  (1997).  Dissection of protein kinase and phosphatase targeting interactions.  In: Cytoskeletal Regulation of Membrane Function, Society of General Physiologists 50th Annual Symposium, 227-239. [pdf]

53. Faux, M.C. and Scott, J.D.  (1997).  Regulation of the AKAP79-protein kinase C interaction by Ca2+/calmodulin.  Journal of Biological Chemistry 272:17038-17044. [pdf]

54. Lester, L.B. and Scott, J.D.  (1997).  Anchoring and scaffold proteins for kinases and phosphatases.  In: Recent Progress in Hormone Research, Proceedings of the 1996 Conference, The Endocrine Society 52:409-430. [pdf]

55. Gao, T., Yatani, A., Dell’Acqua, M.L., Sako, H., Green, S.A., Dascal, N., Scott, J.D. and Hosey, M.M. (1997).  cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits.  Neuron 19:185-196. [pdf]

56. Burton, K.A., Johnson, B.D., Hausken, Z.E., Westenbroek, R.E., Idzerda, R.L., Scott, J.D., Catterall, W.A. and McKnight, G.S.  (1997).  Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca2+ channel activity by cAMP-dependent proteins.  Proceedings of the National Academy of Sciences USA 94:11067-11072. [pdf]

57. Newlon, M.G., Roy, M., Hausken, Z.E., Scott, J.D. and Jennings, P.A.  (1997).  The A-kinase anchoring domain of typeIIa cAMP-dependent protein kinase is highly helical.  Journal of Biological Chemistry 272:23637-23644. [pdf]

58. Pawson, T.J. and Scott, J.D.  (1997).  Signaling through scaffold, anchoring and adaptor proteins.  Science 278:2075-2080. [pdf]

59. Lester, L.B., Langeberg, L.K. and Scott, J.D.  (1997).  Anchoring of PKA is required for cAMP-mediated insulin secretion.  Proceedings of the National Academy of Sciences USA 94:14942-14947. [pdf]


60. Hausken, Z.E., Coghlan, V.M. and Scott, J.D.  (1998).  Overlay, ligand blotting and band-shift techniques to study kinase anchoring.  Methods in Molecular Biology, v. 88. From:  Protein Targeting Protocols.  Edited by: R.A. Clegg, Humana Press Inc., Totowa, NJ, pp.47-64. [pdf]

61. Scott, J.D. and Faux, M.C.  (1998).  Use of synthetic peptides in the dissection of protein-targeting interactions.  Methods in Molecular Biology, v. 88. From:  Protein Targeting Protocols.  Edited by: R.A. Clegg, Humana Press Inc., Totowa, NJ, pp.161-185. [pdf]

62. Dell’Acqua, M.L., Faux, M.C., Thorburn, J., Thorburn, A. and Scott, J.D.  (1998).  Membrane targeting sequences on AKAP79 bind phosphatidylinositol-4,5-bisphosphate.  EMBO Journal 17:2246-2260. [pdf]

63. Fraser, I.D.C., Tavalin, S.J., Lester, L.B., Langeberg, L.K., Westphal, A.M., Dean, R.A., Marrion, N.V. and Scott, J.D.  (1998).  A novel lipid-anchored A-kinase anchoring protein facilitates cAMP-responsive membrane events.  EMBO Journal 17:2261-2272. [pdf]

64. Gray, P.C., Scott, J.D. and Catterall, W.A.  (1998).  Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins.  Current Opinion in Neurobiology 8:330-334. [pdf]

65. Murphy, B.J. and Scott, J.D.  (1998).  Functional anchoring of the cAMP-dependent protein kinase.  Trends in Cardiovascular Medicine 8:89-95. [pdf]

66. Eide, T., Coghlan, V., Orstavik, S., Holsve, C., Solberg, R., Skalhegg, B.S., Lamb, N.J.C., Langeberg, L., Fernandez, A., Scott, J.D., Jahnsen, T. and Tasken, K.  (1998).  Molecular cloning, chromosomal localization and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95.  Experimental Cell Research 238:305-316. [pdf]

67. Hunzicker-Dunn, M., Scott, J.D. and Carr, D.W.  (1998).  Regulation of expression of A-kinase anchoring proteins in rat granulosa cells.  Biology of Reproduction 58:1496-1502. [pdf]


68. Shih, M., Lin, F., Scott, J.D., Wang, H. and Malbon, C.  (1999).  Dynamic complexes of β2-adrenergic receptors with protein kinases and phosphatases and the role of gravin. [pdf]

69. Newlon, M.G., Roy, M., Morikis, D., Hausken, Z.E., Coghlan, V., Scott, J.D. and Jennings, P.A.  (1999).  The molecular basis for protein kinase A anchoring revealed by solution NMR.  Nature Structural Biology 6:222-227. [pdf]

70. Edwards, A.S., Faux, M.C., Scott, J.D. and Newton, A.C.  (1999).  Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C bII.  Journal of Biological Chemistry 274:6461-6468. [pdf]

71. Schillace, R.V. and Scott, J.D.  (1999).  Organization of kinases, phosphatases, and receptor signaling complexes.  Journal of Clinical Investigation 103:761-765. [pdf

72. Schillace, R.V. and Scott, J.D.  (1999).  Association of the yype 1 phosphatase with the cAMP dependent protein kinase anchoring protein AKAP220.  Current Biology  9:321-324. [pdf]

73. Harada, H., Becknell, B., Matthias, W., Mann, M., Huang, L., Taylor, S., Scott, J.D. and Korsmeyer, S. (1999).  Phosphorylation and inactivation of BAD by mitochondrial anchored protein kinase.  Molecular Cell 3:413-422. [pdf]

74. Scott, J.D., Dell’Acqua, M.L., Fraser, I.D.C., Tavalin, S.J. and Lester, L.B.  (1999).  Coordination of cAMP signaling events through PKA anchoring.  In: Hormone and Signaling.  San Diego: Academic Press 2:175-207. [pdf]

75. Colledge, M. and Scott, J.D.  (1999).  AKAPs:  From structure to function.  Trends in Cell Biology   9:216-221. [pdf]

76. Westphal, R, Tavalin, S. J., Lin, J.W., Alto, N.M., Fraser, I.D.C., Langeberg, L.K., Sheng,  M., and Scott, J.D.  (1999)  Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex.  Science 285:93-96. [pdf]

77. Tavalin, S.J., Westphal, R.S., Colledge, M., Langeberg, L.K and Scott, J.D.  (1999).  The molecular architecture of neuronal kinase/phosphatase signaling complexes.  Biochemical Society Transactions 27:539-542.  [pdf]

78. Kapiloff, M.S., Schillace, R., Westphal, A.M. and Scott, J.D.  (1999).  mAKAP:  An A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes.  Journal of Cell Science 112: 2725-2736. [pdf]

79. Fraser, I.D.C. and Scott, J.D.  (1999).  Modulation of Ion Channels: A “current” view of AKAPs.  Neuron 23:423-426. [pdf]

80. Faux, M.C., Rollins, E.N., Edwards, A.S., Langeberg, L.K., Newton, A.C. and Scott, J.D.  (1999). Mechanism of AKAP79 and PKC interaction.  Biochemical Journal 343:443-452. [pdf]

81. Trotter, K.W., Fraser, I.D.C., Scott, G.K., Stutts, M.J., Scott, J.D. and Milgram, S.L.  (1999).  Alternative splicing regulates the subcellular localization of AKAP18 isoforms.  Journal of Cell Biology 147:1481-1492. [pdf]

82. Carr, D.W., Culter, R. E., Cottom, J.E., Salvador, L.M., Fraser, I.D.C., Scott, J.D. and Hunzicker-Dunn, M.  (1999).  Identification of cAMP-dependent protein kinase holoenzymes in preantral and preovulatory-follicle-enriched ovaries, and their association with A-kinase-anchoring proteins.  Biochemical  Journal 344:613-623. [pdf]

back to top


83. Edwards, A.E. and Scott, J.D.  (2000).  A-Kinase anchoring proteins:  PKA and beyond.  Current Opinions in Cell Biology 12:217-221. [pdf]

84. Scott, J.D. and Pawson, T.J.  (2000).  Cellular communications:  “the inside story”.  Scientific American 282:72-79. [pdf]

85. Fraser, I.D.C., Cong, M., Kim, J., Rollins, E.N., Daaka, Y., Lefkowitz, R.J. and Scott,  J.D.  (2000).  Assembly of an AKAP/beta2 -adrenergic receptor signaling complex facilitates receptor phosphorylation and signaling.  Current Biology 10:409-412. [pdf]

86.  Diviani, D., Langeberg, L.K., Doxsey, S. J. and Scott, J.D.  (2000).  Pericentrin anchors protein kinase A at the centrosome through a novel RII binding domain.  Current Biology 10:417-420. [pdf]

87. Sim, A.T.R. and Scott, J.D.  (2000).  Targeting of PKA, PKC and protein phosphatases to cellular microdomains.  Cell Calcium 5:209-217. [pdf]

88. Dodge, K. and Scott, J.D.  (2000).  AKAP79 and the evolution of the AKAP model.  FEBS Letters  476:58-61. [pdf]

89. Colledge, M., Dean, R A., Scott, G.K., Langeberg, L.K., Huganir, R.L. and Scott, J.D.  (2000). Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex.  Neuron 27:107-119. [pdf]

90. Westphal, R.S., Soderling, S.H., Alto, N.M., Langeberg, L.K. and Scott, J.D.  (2000).  Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin associated serine/theronine and tyrosine kinase scaffold.  EMBO Journal 19:4589-4600. [pdf]

91. Lin, D., Edwards, A.E., Fawcett, J.P., Mbamalu, G., Scott, J.D. and Pawson T.J.  (2000).  Mammalian PAR-3/PAR-6 multi-protein complex implicated in Cdc42/Rac1 and aPKC signaling and in cell polarity.  Nature Cell Biology 2:540-547. [pdf]


92. Diviani, D. and Scott, J.D. (2001). AKAP signaling complexes at the cytoskeleton.  Journal of Cell Science 114:1431-1437.   [pdf]              

93. Lester, L.B., Faux, M.C., Nauert, J.B. and Scott, J.D.  (2001).  Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation.  Endocrinology 142:1218-1227.  [pdf]               

94. Newlon, M.G., Roy, M., Morikis, D., Carr, D., Westphal, R., Scott, J.D. and Jennings, P.A.  (2001).  A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes.  EMBO Journal  20:1651-1662. [pdf]

95. Potet, F., Scott, J.D., Escande D. and Baro, I.  (2001).  AKAP Proteins anchor cAMP- dependent protein kinase to KvLQT1/IsK tandem.  American Journal of Physiology 280:2038-2045. [pdf]

96. Cong, M., Fraser, I.D.C., Scott, J.D. and Lefkowitz, R.J.  (2001).  Regulation of GRK mediated phosphorylation of the beta2 -adrenergic receptor by the AKAP79/150 signaling complex.  Journal of Biological Chemistry 276:15192-15199. [pdf]

97. Schillace, R.V., Voltz, J.W., Sim, A.T., Shenolikar, S. and Scott, J.D.  (2001).  Multiple interactions within the AKAP220 signaling complex contribute to PP1 regulation.  Journal of Biological Chemistry 276:12128-12134. [pdf]
98. Dodge, K.L., Khouangsathiene, S., Kaplioff, M.S., Mouton, R., Vill, E.V., Houslay, M.D., Langeberg, L.K. and Scott, J.D.  (2001).  mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module.  EMBO Journal 20:1921-1930. [pdf]

99. Jo, I., Ward, D.T., Baum, M.A., Scott, J.D., Coghlan, V.M., Hammond, T.G. and Harris, H.W.  (2001). AQP2 is a substrate for the endogenous calcineurin activity within an inner medullary AKAP-signaling complex.  American Journal of Physiology Renal Physiology 281:958-965. [pdf]

100. Perkins, G., Wang, L., Huang L., Humphries, K., Yao, V.J., Martone, M., Deernick, T.J., Violin, J.D., Smith, D., Newton, A., Scott, J.D., Taylor, S.S. and Ellisman, M.H.  (2001).  PKA, PKC, and AKAP Localization in and around the neuromuscular junction.  BMC Neuroscience 2:17-27. [pdf]

101. Diviani, D., Soderling, J.A. and Scott, J.D.  (2001).  AKAP-Lbc anchors PKA and nucleates Ga12 selective Rho mediated stress fiber formation.  Journal of Biological Chemistry 276:44247-44257. [pdf]


102. Scott, J.D.  (2002).  Signal transduction according to the book.  Nature Cell Biology 4:E14. [pdf]

103. Smith, F.D. and Scott, J.D.  (2002).  Signaling complexes: junctions on the intracellular information super highway.  Current Biology 12:R32-R40. [pdf]

104. Michel, J. and Scott, J.D.  (2002).  AKAP mediated signal transduction.  Annual Review in Pharmacology 42:235-257. [pdf]

105. Tavalin, S.J., Colledge, M., Hell, J.W., Huganir, R.L. and Scott, J.D.  (2002).  Regulation of Glur1 by the AKAP79 signaling complex shares properties with LTD.  Journal of Neuroscience 22:3044-3051. [pdf]

106. Morikis, D., Roy, M., Newlon, M.G., Scott, J.D. and Jennings, P.A.  (2002).  Electrostatic properties of the structure of the docking and dimerization domain of protein kinase AIIa.  European Journal of Biochemistry 269: 2040-2051. [pdf]

107. Bauman, A.L. and Scott, J.D.  (2002).  Kinase and phosphatase anchoring proteins: harnessing the dynamic duo.  Nature Cell Biology 4:E203-E206. [pdf]

108. Altier, C., Dubel, S.J., Barrere, C., Jarvis, S.E., Stotz, S.C., Spaetgens, R.L., Scott, J.D., Cornet, V., Waard, M.D., Zamponi, G.W., Nargeot, J. and Bourinet, E.  (2002).  Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79.  Journal of Biological Chemistry 277:33598-33603. [pdf]

109. Alto, N.M., Soderling, J. and Scott, J.D.  (2002).  Rab32 is an A-Kinase anchoring protein and participates in mitochondrial dynamics.  Journal of Cell Biology 158:659-668. [pdf]

110. Soderling, S. H., Binns, K.M., Wayman, G.A., Davee, S.M., Ong, S.H., Pawson, T.J. and Scott, J.D.  (2002).  The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.  Nature Cell Biology 4:970-975. [pdf]

111. Dell’Acqua, M.L, Dodge, K.L., Tavalin, S.J. and Scott, J.D.  (2002).  Mapping the protein phosphatase 2-B anchoring site on AKAP79: binding and inhibition of phosphatase activity are mediated by residues 315-360.  Journal of Biological Chemistry 277:48796-48802. PMCID: PMC3923414 [pdf]

112. Alto, N.M, Michel, J., Dodge, K.L., Langeberg, L.K. and Scott, J.D.  (2002).  Intracellular targeting of protein phosphatases.  Diabetes 51:S385-S388. [pdf]


113. Scott, J.D.  (2003).  A-kinase-anchoring proteins and cytoskeletal signalling events.  Biochemical Society Transactions 31:87-89. [pdf]

114. Brandon, N.J., Jovanovic, J.N., Colledge, M., Kittler, J.T., Brandon, J.M., Scott, J.D. and Moss, S.J.  (2003).  A-Kinase anchoring protein 79/150 facilitates the phosphorylation of GABAA receptors by cAMP-dependent protein kinase via selective interaction with receptor b subunits.  Molecular and Cellular Neuroscience 22:1:87-97. [pdf]

115. Soderling, S.H., Langeberg, L.K., Soderling, J.A., Davee, S.M., Raber, J. and Scott, J.D.  (2003).  Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.  Proceedings of the National Academy of Sciences USA 100:1723-1728. [pdf]

116. Alto, N.M., Soderling, S.H., Hoshi, N., Langeberg, L.K., Fayos, R., Jennings, P.A. and Scott, J.D. (2003).  Bioinformatic design of AKAP “in-silico”: a potent and selective peptide antagonist of type II protein kinase A anchoring.  Proceedings of the National Academy of Sciences USA 100:4445-4450. [pdf]

117. Hoshi, N., Zhang, J., Omaki, M., Takeuchi, T., Yokoyama, S., Wanaverbecq, N., Langeberg, L.K., Yoneda, Y., Scott, J.D., Brown, D.A. and Higashida, H.  (2003).  AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists.  Nature Neuroscience 6: 564-571. PMCID: PMC3941299 [pdf] [supp Fig1]

118. Fayos, R., Melacini, G., Newlon, M.G., Burns, L., Scott, J.D. and Jennings, P.A.  (2003).  Induction of flexibility through protein-protein interactions.  Journal of Biological Chemistry 278:18581-18587. [pdf]

119. Scott, J.D.  (2003).  Protein proximity interactions.  Handbook for Cellular Signaling 171:293-297.

120. Langeberg, L.K. and Scott, J.D.  (2003).  AKAP signaling complexes:  the  combinatorial assembly of signal transduction units.  Handbook for Cellular Signaling 186:387-392.                 

121. Ruehr, M.L., Russell, M.A., Ferguson, D.G., Bhat, M., Ma, J., Damron, D.S., Scott, J.D. and Bond, M. (2003).  Targeting of PKA by mAKAP regulates phosphorylation and function of the skeletal muscle ryanodine receptor.  Journal of Biological Chemistry 278:24831-24836. [pdf]

122. Carnegie, G.K. and Scott, J.D.  (2003).  A-kinase anchoring proteins and neuronal signaling mechanisms.  Genes & Development 17:1557-1568. [pdf]

123. Colledge, M., Snyder, E.M., Crozier, R.A., Soderling, J.A., Jin, Y., Langeberg, L.K., Lu, H., Bear, M.F. and Scott, J.D.  (2003).  Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.  Neuron 40:595-607. PMCID: PMC3963808 [pdf] [supp 1] [supp 2]

124. Dodge, K.L. and Scott, J.D.  (2003).  Calcineurin anchoring and cell signaling.  Biochemical and Biophysical Research Communications 311:1111-1115. [pdf]


125. Bauman, A.L., Goehring, A.S. and Scott, J.D.  (2004).  Orchestration of synaptic plasticity through AKAP signaling complexes.  Journal of Neuropharmacology 3:299-310. [pdf]

126. Alto, N.M. and Scott, J.D.  (2004).  The role of A-kinase anchoring proteins in cAMP-mediated signal transduction pathways.  Cell Biochemistry & Biophysics 40:201-208. [pdf]

127. Salvador, L.M., Flynn, M.P., Avila, J., Reierstad, S., Maizels, E.T., Alam, H., Park Y., Scott, J.D., Carr, D.W. and Hunzicker-Dunn, M.  (2004).  Neuronal microtubule-associated protein 2D is a dual A-kinase anchoring protein expressed in rat ovarian granulosa cells.  Journal of Biological Chemistry 279:27621–27632. [pdf]

128. Carlisle Michel, J.J., Dodge, K.L., Wong, W., Mayer, N.C., Langeberg, L.K. and Scott, J.D.  (2004). PKA phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex.  Biochemical Journal 381:587-592. [pdf]

129. Jin, J., Smith, F.D., Stark, C., Wells, C.D., Fawcett, J.P., Kulkarni, S., Metalnikov, P., O’Donnell, P., Taylor, P., Taylor, L., Zougman, A., Woodgett, J.R., Langeberg, L.K., Scott, J.D. and Pawson, T.J. (2004).  Proteomic, functional and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.  Current Biology 14:1436-1450. [pdf]

130. Carnegie, G.K., Smith, F.D., McConnachie, G., Langeberg, L.K. and Scott, J.D.  (2004).  AKAP-Lbc nucleates a protein kinase D activation scaffold.  Molecular Cell 15:889-899. [pdf]

131. Langeberg, L.K. and Scott, J.D.  (2004).  A-kinase anchoring proteins, in Encyclopedia of Biological Chemistry (W.J. Lennarz & M.D. Lane, eds), Elsevier, Oxford, Vol. 1, pp. 64-67. [pdf]

132. Wong, W. and Scott, J.D.  (2004).  AKAP signalling complexes: focal points in space and time.  Nature Reviews Cell Biology 5:959-970. [pdf]


133. Li, Y., Keller, D.M., Scott, J.D. and Lu, H.  (2005).  CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity.  Journal of Biological Chemistry 280:11869-11875. PMCID: PMC3923407 [pdf]

134. Snyder, E.M., Colledge, M., Crozier, R.A., Chen, W.S., Scott, J.D. and Bear, M.F.  (2005).  Role for A kinase anchoring proteins (AKAPs) in glutamate receptor trafficking and long-term synaptic depression.  Journal of Biological Chemistry 280:16962-16968. PMCID: PMC3923403 [pdf]

135. Baillie, G.S., Scott, J.D. and Houslay, M.D.  (2005).  Compartmentalization of phosphodiesterases and protein kinase A: opposites attract.  FEBS Letters 579:3264-3270.[pdf]

136. Pawson, T.J. and Scott, J.D.  (2005).  Protein phosphorylation in signaling – 50 years and counting. Trends in Biochemical Sciences 30:286-290. [pdf]

137. Langeberg, L.K. and Scott, J.D.  (2005).  AKAPs at a glance.  Journal of Cell Science 118:3217-3220. [pdf]

138. Gorski, J., Gomez, L., Scott, J.D. and Dell’Acqua, M.  (2005).  Association of an AKAP signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells.  Molecular Biology of the Cell 16:3574-90. [pdf]

139. Dodge-Kafka, K.L., Soughayer, J., Pare, G.C., Carlisle Michel, J.J., Langeberg, L.K., Kapiloff, M.S. and Scott, J.D.  (2005).  The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.  Nature 437:574-8. PMCID: PMC1636584 [pdf]

140. Hoshi, N., Langeberg, L.K. and Scott, J.D.  (2005).  Distinct enzyme combinations in AKAP signaling complexes permit functional diversity.  Nature Cell Biology 7:1066-1073. PMCID: PMC3923410 [pdf]

141. Michel, J.C., Townley, I.K., Dodge-Kafka, K.L., Zhang, F., Kapiloff, M.S. and Scott, J.D.  (2005). Spatial restriction of PDK1 activation cascades by anchoring to mAKAPα.  Molecular Cell 20:661-672. [pdf]

back to top


142. Soderling, S.H. and Scott, J.D.  (2006).  WAVE signalling-from biochemistry to biology.  Biochemical Society Transactions 34:73-76. [pdf]

143. Dodge-Kafka, K.L., Langeberg L.K. and Scott, J.D.  (2006).  Compartmentalization of cyclic nucleotide signaling in the heart:  the role of A-kinase anchoring proteins.  Circulation Research 98:993-1001. [pdf]

144. Willoughby, D., Wong, W., Schaack, J., Scott, J.D. and Cooper, D.M.F.  (2006).  An anchored PKA and PDE4 complex regulates sub-plasmalemmal cAMP dynamics.  EMBO Journal 25:2051-2061. [pdf]

145. Hundsrucker, C., Krause, G., Beyermann, M., Prinz, A., Zimmermann, B., Diekmann, O., Lorenz, D., Stefan, E., Nedvet-sky, P., Dathe, M., Christian, F., McSorley, T., Krause, E., McConnachie, G., Herberg, F.W., Scott, J.D., Rosenthal, W. and Klussmann, E.  (2006).  High-affinity AKAP18δ-protein kinase A interaction yields novel protein kinase A anchoring disruptor peptides.  Biochemical Journal 396:297-306. PMC: PMCID1462715 [pdf]

146. Hoshi, N. and Scott, J.D.  (2006).  Contextual utilization of enzymes in discrete AKAP79/150 signalling complexes.  European Journal of Cell Biology 85:621-622. [pdf]

147. Smith, F.D. and Scott, J.D.  (2006).  Anchored cAMP signaling: onward and upward – a short history of compartmentalized cAMP signaling transduction.  European Journal of Cell Biology 85:585-592. [pdf]

148. Smith, F.D., Langeberg, L.K. and Scott, J.D.  (2006).  The where’s and when’s of kinase anchoring.  Trends in Biochemical Science 31:316-323. [pdf]

149. Kim, Y., Sung, J.Y., Ceglia, I., Lee, K., Ahn, J., Halford, J.M., Kim, A., Kwak, S.P., Park, J.B., Ryu, S.H., Schenck, A., Bardoni, G., Mandel, J., Scott, J.D., Nairn, A.C. and Greengard, P.  (2006).  Phosphorylation of WAVE-1 regulates actin polymerization and dendritic spine morphology.  Nature 442:814-817. [pdf]

150. Bauman, A.L., Soughayer, J., Nguyen, B.T., Willoughby, D., Wong, W., Hoshi, N., Langeberg, L.K., Cooper, D.M.F., Dessauer, C.W. and Scott, J.D.  (2006).  Dynamic regulation of cAMP synthesis through anchored PKA/adenylyl cyclase V/VI complexes.  Molecular Cell 23:925-931. PMCID: PMC3941446 [pdf] [supp]

151. Carlson, C.R., Lygren, B., Berge, T., Hoshi, N., Wong, W., Tasken, K. and Scott, J.D.  (2006). Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor (RIAD).  Journal of Biological Chemistry 281:21535-21545. [pdf]

152. McConnachie, G., Langeberg, L.K. and Scott, J.D.  (2006).  AKAP signaling complexes: getting to the heart of the matter.  Trends in Molecular Medicine 12:317-23. [pdf]

153. Scott, J.D.  (2006).  Compartmentalized cAMP signaling: a personal perspective.  Biochemical Society Transactions 34:465-467. [pdf]

154. Gardner, L.A., Tavalin, S.J., Goehring, A., Scott, J.D. and Bahouth, S. W.  (2006).  AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the ß1-adrenergic receptor promotes recycling and functional resensitization of the receptor.  Journal of Biological Chemistry 281:33537-53. [pdf]

155. Gold, M.G., Lygren, B., Dokurno, P., Hoshi, N., McConnachie, G., Tasken, K., Carlson, C.R., Scott and J.D., and Barford, D.  (2006).  Molecular basis of AKAP specificity for PKA regulatory subunits.  Molecular Cell 24:383-95. [pdf] [supp]

156. Stokka, A.J., Gesellchen, F., Carlson, C.R., Scott, J.D., Herberg, F.W. and Tasken, K.  (2006).  Characterization of A-kinase anchoring disruptors using a solution based assay.  Biochemical Journal 400:493-9. PMC: PMCID1698590 [pdf]


157. Soderling, S.H., Guire, E.S., Kaech, S., White J., Zhang, F., Schutz, K., Langeberg, L.K., Banker, G., Raber, J. and Scott, J.D.  (2007).  A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity and memory. Journal of Neuroscience 27:355-365. PMCID: PMC3740594 [pdf]

158. Beene, D.L. and Scott, J.D.  (2007).  A-kinase anchoring proteins take shape.  Current Opinion in Cell Biology 19:192-198. PMCID: PMC3521038 [pdf]
159. Goehring, A.S., Pedroja, B.S., Hinke, S.A., Langeberg, L.K. and Scott, J.D.  (2007).  MyRIP anchors protein kinase A to the exocyst complex. Journal of Biological Chemistry 282:33155-33167. PMCID: PMC3508720 [pdf]


160. Gold, M.G., Smith, F.D., Scott, J.D. and Barford, D.  (2008) AKAP18 contains a phosphoesterase domain that binds AMP. Journal of Molecular Biology 375(5):1329-1343. PMCID: PMC3188456 [pdf]

161. Klussman, E. and Scott, J.D.  (2008) Protein-Protein Interactions as New Drug Targets: Introduction (Handbook of Experimental Pharmacology 186) (E. Klussman & J.D. Scott, eds.), Springer-Verlag, Berlin Heidelberg pp. 483-503.

162. Langeberg, L.K. and Scott, J.D.  (2008).  AKAP transduction units: Context-dependent assembly of signaling complexes, in Handbook of Cell Signaling - 2nd ed. (R. Bradshaw & E. Dennis, eds.), Elsevier pp. 1337-1342.

163. Gold, M. and Scott, J.D.  (2008) Protein proximity interactions, in Handbook of Cell Signaling - 2nd ed. (R. Bradshaw & E. Dennis, eds.), Elsevier pp. 1245-1246.

164. Tunquist, B.J., Hoshi, N., Guire, E.S., Zhang, F., Müllendorff, K., Langeberg, L.K., Raber, J. and Scott, J.D.  (2008) Loss of AKAP150 perturbs distinct neuronal processes in mice.  Proceedings of the National Academy of Sciences USA 105:12557-12562. PMCID: PMC2527950 [pdf]

165. Piggott, L.A., Bauman, A.L., Scott, J.D. and Dessauer, C.W.  (2008) The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain. Proceedings of the National Academy of Sciences USA 105:13835-13840. PMCID: PMC2544540 [pdf]

166. Carnegie, G.K., Soughayer, J., Smith, F.D., Pedroja, B.S., Zhang, F., Diviani, D., Bristow, M.R., Kunkel, M.T., Newton, A.C., Langeberg, L.K., and Scott, J.D.  (2008) AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Molecular Cell 32:169-179. PMCID: PMC3169907 [pdf]

167. Jarnæss, E., Ruppelt, A., Stokka, A., Lygren, B., Scott, J.D. and Taskén, K. (2008)  Dual-Specificity A-Kinase Anchoring Proteins (AKAPs) Contain An Additional Binding Region That Enhances Targeting of PKA Type  I1, Journal of Biological Chemistry 283: 33708-33718. PMCID: PMC2586281 [pdf]

168. Paulucci-Holthauzen, A.A., Vergara, L.A., Bellot, L.J., Canton, D., Scott, J.D. and O’Connor, K.L. (2008) Spatial Distribution of PKA Activity during Cell Migration is Mediated by A-Kinase Anchoring Protein AKAP Lbc. Journal of Biological Chemistry 284:5956-5967. PMCID: PMC2645839 [pdf]

169. Wong, W., Goehring, A.S., Kapiloff, M.S., Langeberg, L.K. and Scott, J.D.  (2008) mAKAP compartmentalizes oxygen-dependent control of HIF-1α. Science Signaling 1:84-92. PMCID: PMC2828263 [pdf]


170. Carnegie, G.K., Means, C.K., and Scott, J.D. (2009) A-kinase Anchoring Proteins: from Protein Complexes to Physiology and Disease. IUBMB Life 61:394-406. PMCID: PMC2682206 [pdf]

171. Smith, F.D., Langeberg, L.K. and Scott, J.D. (2009). Spatial and temporal control of cell signaling by A-kinase Anchoring Proteins. In: Signal Transduction: Pathways, Mechanisms and Diseases   (A. Sitaramayya, editor). Springer-Verlag,  Berlin Heidelberg. pp. 183-197

172. Jarnæss, E, Stokka, A.J., Kvissel, A-K, Skålhegg, B.S., Torgersen, K.M., Scott, J.D., Carlson, C.R. and Taskén, K. (2009). Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-Kinase anchoring protein that targets protein kinase A to splicing factor compartments. Journal of Biological Chemistry 284:35154-35164. PMCID: PMC2787376 [pdf] [supp]

173. Scott, J.D. and Pawson, T. (2009). Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart. Science 326:1220-1224. PMCID: PMC3041271 [pdf]


174. Hoshi N., Langeberg, L.K., Gould, C.M., Newton, A.C., and Scott, J.D. (2010) Interaction with AKAP79 modifies the cellular pharmacology of PKC. Molecular Cell 37:541-550. PMCID: PMC3014287 [pdf]

175. Scott, J.D. and Santana, L.F. (2010) A-Kinase Anchoring Proteins: getting to the heart of the matter. Circulation 121:1264-1271. PMCID: PMC3014256 [pdf]

176. Hinke, S.A., Canton, D.A. and Scott J.D. (2010). Control of Insulin Secretin by Phosphorylation-Dependent Signalling Networks. In: Islet Transplantation: Biology, Immunology and Clinical Applications. (ed. Kandeel FR). Springer, New York, NY. 3:17-24.

177. Navedo, M.F., Cheng, E.F., Yuan, C., Votaw, S., Molkentin, J.D., Scott, J.D., and Santana, L.F. (2010) Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy Syndrome. Circ. Res. 106:748-756. PMCID: PMC2834417 [pdf]

178. Catterall, W. and Scott, J.D. (2010) Retrospective. Edwin G. Krebs (1918-2009). Science 327:537. PMID:20110494 [pdf]

179. Efendiev R, Samelson BK, Nguyen B, Phatarpekar P, Baameur F, Scott JD and Dessauer, C.W. (2010) AKAP79 Interacts with Multiple Adenylyl Cyclase (AC) Isoforms and Scaffolds AC 5 and 6 to AMPA Receptors. Journal of Biological Chemistry 285:14450-14458. PMCID: PMC2863235 [pdf] [supp]

180. Welch, E.J., Jones, B.W., and Scott, J.D. (2010) Networking with AKAPs: context-dependent regulation of anchored enzymes. Molecular Interventions 10:86-97. PMCID: PMC2895371 [pdf]

181. Scott, J.D. (2010) Edwin G. Krebs (1918-2009) Our Beloved "Reluctant" Biochemist. ASBMB Today January:11-15. [pdf]

182. Logue, J.S. and Scott, J.D. (2010) Organizing Signal Transduction through A-Kinase Anchoring Proteins (AKAPs). FEBS J. 277:4370-4375 published online: 30 SEP 2010. PMCID: PMC3014294 [pdf]

183. Pawson, C. and Scott, J.D. (2010) Signal Integration through blending, bolstering and bifurcating of intracellular information. Nature Structural & Molecular Biology 17:653-658. PMCID: PMC3086636. [pdf]

184. Bui, M., Gilady, S.Y., Fitzsimmons, R.E.B., Lynes E.M., Gesson, K., Alto, N., Strack, S., Scott, J.D., and Simmen, T. (2010) Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties. Journal of Biological Chemistry 285:31590-31602. PMCID: PMC2951233 [pdf]

185. Por, E.D., Samelson, B.K., Belugin, S., Akopian, A.N, Scott, J.D., and Jeske, N.A. (2010) PP2B/calcineurin-mediated desensitization of TRPV1 channels does not require AKAP150. Biochem. J. 432:549-556. PMCID: PMC3050517[pdf]

186. Canton, D.A. and Scott, J.D. (2010) Chk-ing in and Chk-ing out: Kinase Compartmentalization Comes to Checkpoint Control. Molecular Cell 40:1-2. PMCID: PMC3014293 [pdf]

187. Smith, F.D., Langeberg, L.K., Cellurale, C., Pawson, T., Morrison, D.K., Davis, R.J., and Scott, J.D. (2010) AKAP-Lbc enhances cAMP control of the ERK1/2 cascade. Nature Cell Biology 12:1242-1249. PMCID: PMC3042953 [pdf]

188. Lyssand, J.S., Whiting, J.L., Lee, K.-S., Kastl, R., Wacker, J.L., Bruchas, M., Miyatake, M., Langeberg, L.K., Chavkin, C., Scott, J.D., Gardner, R., Adams, M.E., and Hague, C. (2010) α-Dystrobrevin-1 recruits α-Catulin to the α1D-Adrenergic Receptor/DAPC Signalosome. Proceedings of the National Academy of Science USA 107:21854-21859. PMCID: PMC3003112 [pdf] [supp] [supp2]

back to top


189. Wanichawan, P., Louch, W., Austbø, B., Scott, J.D, Sejersted, O., and Carlson, C.R. (2011) Full length cardiac Na2+ - Ca2+ exhanger (NCX1) protein is not phosphorylated by protein kinase A (PKA). American Journal of Physiology – Cell Physiology 300:C989-997. PMCID: PMC3093950 [pdf]

190. Perino, A., Ghigo, A., Ferrero, E., Morello, F., Santulli, G., Baillie, G., Damilano, F., Dunlop, A.J., Pawson, C., Walser, R., Levi, R., Altruda, F., Silengo, L., Langeberg, L.K., Neubauer, G., Heymans, S., Lembo, G., Wymann, M.P., Wetzker, R., Houslay, M.D., Iaccarino, G., *Scott, J.D., and *Hirsch, E. (co-corresponding authors). (2011) Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Molecular Cell 42:84-95. PMCID: PMC3265115 [pdf] [supp]

191. Smith, F.D., Langeberg, L.K., and Scott, J.D. (2011) Plugging PKA into ERK scaffolds. Cell Cycle 10:731-732. PMCID: PMC3322337 [pdf]

192. Gold, M., Stengel, F., Nygren, P., Weisbrod, C.R., Bruce, J.E., Robinson, C., Barford, D., Scott, J.D. (2011) Architecture and Dynamics of the AKAP79 Signaling Complex. Proceedings of the National Academy of Science 108:6426-6431. PMCID: PMC3081024 [pdf] [supp]

193. Carnegie, G.K. and Scott, J.D. (2011) A-Kinase Anchoring Protein (AKAP). Encyclopedia of Signaling Molecules. In: Encyclopedia of Signalling Molecules Choi S, editor. Encyclopedia of Signaling Molecules: Springer New York; 2012. pp. 89-96. [pdf]

194. Day, M.E., Gaietta, G.M., Sastri, M., Koller, A., Mackey, M.R., Scott, J.D., Perkins, G.A., Ellisman, M.H., and Taylor, S.S. (2011) Isoform-specific targeting of PKA to multivesicular bodies. Journal of Cell Biology 193:347-363. PMCID: PMC3080257 [pdf]

195. Logue, J.S., Whiting, J.L., Tunquist, B.J., Langeberg, L.K., and Scott, J.D. (2011) Anchored PKA Recruitment of Active RAC. Journal of Biological Chemistry 286:22113-22121. PMCID: PMC3121355 [pdf] [supp]

196. Smith, F.D., Samelson, B.K., and Scott, J.D. (2011) Discovery of cellular substrates for Protein Kinase A by a peptide array screening protocol. Biochemical Journal 438:103-110. PMCID: PMC3292260 [pdf]

197. Logue, J.S., Whiting, J.L., and Scott, J.D. (2011) Sequestering Rac with PKA confers cAMP control of cytoskeletal remodeling. Small GTPases 2:173-176. PMCID: PMC3136949 [pdf]

198. Cheng, E.P., Yuan, C., Navedo, M.F., Dixon, R.E., Scott, J.D., and Santana, L.F. (2011) Restoration of normal L-type Ca2+ channel function during Timothy syndrome by ablation of an anchoring protein. . Circ Res,. 109:255-261. PMCID: PMC3151468. [pdf]

199. Edwards, H.V., Scott, J.D., and Baillie, G. (2011) PKA phosphorylation of the small heat shock protein Hsp20 enhances its cardioprotective effects. Biochemical Society Transactions 40:210-214. PMCID: PMC3269834 [pdf]

200. Logue, J.S., Whiting, J.L., Tunquist, B.J., Sacks, D.B., Langeberg, L.K., Wordeman, L., and Scott, J.D. (2011) AKAP220 Organizes Signaling Elements that Impact Cell Migration. Journal of Biological Chemistry 286:39269-39281. PMCID: PMC3234751 [pdf]

201. Means, C.K., Lygren, B., Langeberg, L.K., Jain, A., Dixon, R.E., Vega, A.L., Gold, M.G., Petrosyan, S., Taylor, S.S., Murphy, A.N., Ha, T., Santana, L.F., Taskén, K., and Scott, J.D. (2011) An entirely specific type I A-kinase anchoring protein that can sequester two molecules of PKA at mitochondria. Proceedings of the National Academy of Science 108:E1227-E1235. PMCID: PMC3228425 [pdf]


202. Gold, M., Reichow, S.L., O'Neal, S.E., Weisbrod, C.R., Langeberg, L.K., Bruce, J.E., Gonen, T., and Scott, J.D. (2012) AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency. EMBO Molecular Medicine 4:15-26. PMCID: PMC3272850 [pdf] [supp] [closeup]

203. Kosenko, A., Kang, S., Smith, I.M., Greene, D.L., Langeberg, L.K., Scott, J.D., and Hoshi, N. (2012) Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. EMBO Journal 31:3147-31569. PMCID: PMC3400014 [pdf]

204. Wang, B., Means, C.K., Yang, Y., Mamonova, T., Bisello, A., Altschuler, D.L., Scott, J.D., and Friedman, P.A. (2012) Ezrin anchored PKA Coordinates Phosphorylation-dependent Disassembly of a NHERF-1 Ternary Complex to Regulate Hormone-sensitive Phosphate Transport. Journal of Biological Chemistry 287:24148-24163. PMCID: PMC3397842 [pdf]

205. Altier, C., Dubel, S.J., Barrere, C., Jarvis, S.E., Stotz, S.C., Scott, J.D., Nargeot, J., Zamponi, G., W., and Bourinet, E. (2012) AKAP79 modulation of L-type channels involves disruption of intramolecular interactions in the Cav1.2 subunit. Channels 6:157-165. PMCID: PMC3431589 [pdf]

206. Scott, J.D. and Newton, A.C. (2012) Shedding light on local kinase activation. BMC Biology 10:61. PMCID: PMC3398854 [pdf]

207. Perino, A., Ghigo, E., Scott, J.D., and Hirsch, E. (2012)) Anchoring Proteins as Regulators of Signaling Pathways. Circulation Research 111:482-492. PMCID: PMC3508715 [pdf]

208. Edwards, H.V., *Scott, J.D., and *Baillie, G. (co-corresponding authors) (2012) The A-kinase anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16). Biochemical Journal 446:437-443. PMCID: PMC3498943

209. Scott, J.D., Dessauer, C.W., and Taskén, K. (2013) Creating order from chaos: Cellular regulation by kinase anchoring. Annual Review of Pharmacology and Toxicology 53:187-210 (2013). PMCID: PMC3540170 [pdf]

210. Canton, D.A., Keene, C.D., Swinney, K., Langeberg, L.K., Nguyen, V., Pelletier, L., Pawson, T., Wordeman, L., Stella, N., and Scott, J.D. (2012) Gravin is a transitory effector of polo-like kinase 1 during cell division. Mol Cell. 48:547-559. PMCID: PMC3513578. [pdf] [supp]

211. Hinke, S.A., Navedo, M.F., Ulman, A., Whiting, J.L., Nygren, P., Geng, T., Jimenez-Caliani, A.J., Langeberg, L.K., Cirulli, V., Tengholm, A., Dell'Acqua, M.L., Santana, L.F., and Scott, J.D. (2012) Anchored Phosphatases Modulate Glucose Homeostasis. EMBO Journal 31:3991-4004. PMCID: PMC3474922 [pdf] [Have You Seen?] [GEN article]

212. Jones, B.W., Brunet, S., Gilbert, M., Nichols, B., Su, T., Westenbroek, R.E., Scott, J.D., Catterall, W.A., and McKnight, G.S. (2012) Cardiomyocytes from AKAP7 Knockout Mice Respond Normally to Adrenergic Stimulation. Proceedings of the National Academy of Sciences USA 109:17099-17104. PMCID: PMC3479465 [pdf]

213. Havekes, R., Canton, D.A., Park, A.J., Huang, T., Nie, T., Day, J.P., Guercio, L.A., Grimes, Q., Luczak, V., Gelman, I., Baillie, G., Scott, J.D., and Abel, T. (2012) Gravin orchestrates PKA and β2-adrenergic receptor signaling critical for synaptic plasticity and memory. Journal of Neuroscience 32:18137-18149. PMCID: PMC3533251 [pdf]


214. Smith, F.D. and Scott, J.D. (2013) A-kinase-anchoring protein-Lbc connects stress signaling to cardiac hypertrophy. Molecular and Cellular Biology 33:2-3. PMCID: PMC3536311 [pdf]

215. Canton, D.A. and Scott, J.D. (2013) Anchoring proteins encounter mitotic kinases. Cell Cycle. 12:863-864. PMCID: PMC3637338. [pdf]

216. Gold, M.G., Fowler, D.M., Means, C.K., Pawson, C.T., Stephany, J.J., Langeberg, L.K., Fields, S., and Scott, J.D. (2013) Engineering A-Kinase Anchoring Protein-selective regulatory subunits of Protein Kinase A through structure-based phage selection. Journal of Biological Chemistry 288:17111-17121. PMCID: PMC3682517 [pdf] [supp]

217. Matt, U., Sharif, O., Martins, R., Furtner, T., Langeberg, L.K., Gawish, R., Elbau, I., Zivkovic, A., Lakovits, K., Oskolkova, O., Doninger, B., Vychytil, A., Perkmann, T., Schabbauer, G., Binder, C., Bochkov, V., Scott, J.D., and Knapp, S. (2013) WAVE-1 mediates suppression of phagocytosis by phospholipid-derived DAMPs. Journal of Clinical Investigation 123:3014-3024. PMCID: PMC3696563 [pdf]

218. Smith, F.D. and Scott, J.D. (2013) Scaffolding proteins: not such innocent bystanders. Current Biology 23:R515-R517. PMCID: PMC3924780. [pdf]

219. Gold, M.G., Gonen, T., and Scott, J.D. (2013 ) Local  cAMP Signaling in disease at a glance. Journal of Cell Science 126:4537-4543. PMCID: PMC3795333 [pdf] [full poster] [panel1] [panel2] [panel3] [panel4] [panel5]

220. Scott, J.D. (2013) Tony Pawson  1952-2013. Nature Structural & Molecular Biology 20:1146. [pdf]

221. Heldin, C.-H. and Scott, J.D. (2013) Tony Pawson  1952-2013. Nature Cell Biology 15:1143. [pdf]

222. Smith, F.D., Reichow, S.L., Esseltine, J., Shi, D., Langeberg, L.K., *Scott, J.D., and *Gonen, T.(co-corresponding authors) (2013) Intrinsic disorder within an AKAP-Protein kinase A complex guides local substrate phosphorylation. eLife. eLife 2013;2:e01319. PMCID: PMC3814001 [pdf]

223. Esseltine, J. and Scott, J.D. (2013) AKAP signaling complexes: pointing towards the next generation of therapeutic targets? Trends Pharmacological Sciences.  34:648-655. PMCID: PMC3879114 [pdf]


224. Pruneda, J.N., Smith, F.D., Daurie, A., Swaney, D.L., Villén, J., Scott, J.D., Stadnyk, A.W., LeTrong, I., Stenkamp, R.E., Klevit, R.E., Rohde, J.R., and Brzovic, P.S. (2014) E2~Ub conjugates regulate kinase activity of Shigella effector OspG during pathogenesis. EMBO Journal. 33:437-449. PMCID: PMC3989626 [pdf]

225. Nystoriak, M.A., Nieves-Cintron, M., Nygren, P.J., Hinke, S.A., Nichols, C.B., Chen, C.Y., Puglisi, J.L., Izu, L.T., Bers, D.M., Dell'acqua, M.L., Scott, J.D., Santana, L.F., and Navedo, M.F. (2014) AKAP150 Contributes to Enhanced Vascular Tone by Facilitating BKca Channel Remodeling in Hyperglycemia and Diabetes Mellitus. Circulation Research. 114:607-615. PMCID: PMC3954117 [pdf]

226. Mercado, J., Baylie, R., Navedo, M.F., Yuan, C., Scott, J.D., Nelson, M.T., Brayden, J.E., and Santana, L.F. (2014) Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle. Journal of General Physiology. 143:559-575.  PMCID: PMC4003184 [pdf]

227. Sonkusare, S.K., Dalsgaard, T., Bonev, A.D., Hill-Eubanks, D.C., Kotlikoff, M.I., Scott, J.D., Santana, L.F., and Nelson, M.T. (2014) AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension. Science Signaling. 2014 Jul 8;7(333):ra66 PMCID: PMC4403000 [pdf] [supp]

228. Murphy, J.G., Sanderson, J.L., Gorski, J.A., Scott, J.D., Catterall, W.A., Sather, W.A., and Dell'Acqua, M.L. (2014) AKAP-Anchored PKA maintains Neuronal L-type Calcium Channel Activity and NFAT Transcriptional Signaling. Cell Reports. 7:1577-1588. PMCID: PMC4136445 [pdf] [supp1]



229. Langeberg, L.K. and Scott, J.D. (2015) Signalling scaffolds and local organization of cellular behaviour. Nature Reviews Molecular Cell Biology. 16:232-244. PMCID: PMC4722875 [pdf]

230. Nieves-Cintron, M., Nystoriak, M.A., Prada, MP., Johnson, K., Fayer, W., Dell'Acqua, M.L., Scott, J.D., and Navedo, M.F. (2015) Selective Downregulation of KV2.1 Function Contributes to Enhanced Arterial Tone During Diabetes. Journal of Biological Chemistry. 290:7918-7929. PMCID: PMC4367290. [pdf]

231. Kennedy, E.J. and Scott, J.D. Selective disruption of the AKAP signaling complexes. In: Zaccolo M, editor. Methods in Molecular Biology New York City, NY: Springer Science & Business Media LLC; 2015. pp. 137-150. PMCID: PMC4722817 [pdf]

232. Wang, Y., Ho., T., Franz, E., Hermann, J., Smith, F.D., Hehnly, H., Esseltine, J., Hanold, L., Murph, M., Betinetti, D., Scott, J.D., Herberg, F., and Kennedy, E.J. (2015) PKA-type I Selective Constrained Peptide Disruptors of AKAP Complexes. ACS Chemical Biology. 10:1502-1510. PMCID: PMC4475429. [pdf]

232. Samelson, B.K., Gore, B., Whiting, J.L., Nygren, P., Purkey, A.M., Colledge, M., Langeberg, L.K., Dell'Acqua, M.L., Zweifel, L.S., and Scott, J.D. (2015) A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors. Journal of Biological Chemistry. 290:14107-14119. PMCID: PMC4447981. [pdf]

234. Whiting, J.L., Nygren, P., Tunquist, B.J., Langeberg, L.K., Seternes, O. and Scott, J.D. (2015) Protein Kinase A Opposes the Phosphorylation-Dependent Recruitment of Glycogen Synthase Kinase 3β to A-Kinase Anchoring Protein 220. Journal of Biological Chemistry. 290:19445-19457. PMCID: PMC4528109. [pdf]

235. Nygren, P. and Scott, J.D. (2015) Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder. Frontiers in Pharmacology. 6:(158):1-10. PMCID: PMC4516873. [pdf]

236. Hehnly, H., Canton, D.A., Bucko, P., Langeberg, L.K., Ogier, L., Gelman, I., Santana, L.F., Wordeman, L., and Scott, J.D. (2015) A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germline stem cells. eLife 2015;10.7554/eLife.09384. PMCID: PMC4612572.[pdf]

back to top


237. Turnham, R. and Scott, J.D. (2016) Protein kinase A catalytic subunit isoform PRKACA; history, function and physiology Gene. 577:101-108. PMCID: PMC4713328. [pdf]

238. Nieves-Citrón, M., Hirenallur Shanthappa, D., Nygren, P., Hinke, S.A., Dell'Acqua, M.L., Langeberg, L.K., Navedo, M.F., Santana, L.F., and Scott, J.D. (2016) AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction. Cellular Signalling 7:733-740. PMCID: PMC4902329 [pdf]

239. Riggle, K.M., Riehle, K.J., Kenerson, H.L., Turnham, R., Homma, M., Kazami, M., Samelson, B.K., Bauer, R., McKnight, G.S., Scott, J.D., and Yeung, R.S. (2016) Enhanced cAMP-stimulated Protein Kinase A Activity in Human Fibrolamellar Hepatocellular Carcinoma. Pediatric Research. 80(1):110-118. PMCID: PMC5105330 [pdf]

240. Riggle, K.M., Turnham, R., Scott, J.D., Yeung, R.S., and Riehle, K.J. (2016) Fibrolamellar Hepatocellular Carcinoma: Mechanistic Distinction From Adult Hepatocellular Carcinoma. Pediatric Blood and Cancer. 63:1163-1167. PMCID: PMC4877189.[pdf]

241. Cherry, A.E., Haas, B.R., Naydenov, A.V., Fung, S., Xu, C., Swinney, K., Wagenbach, M., Freeling, J., Canton, D.A., Coy, J., Horne, E.A., Rickman, B., Vicente, J.J., Scott, J.D., Ho, R.J.Y., Liggitt, D., Wordeman, L., and Stella, N. (2016) ST-11: a new brain-penetrant microtubule-destabilizing agent with therapeutic potential for gliomblastoma multiforme. Mol Cancer Ther. 15:2018-2029. PMCID: PMC5010991. [pdf]

242. Scott, J.D. and Newton, A.C. (2016), Bacterial spore coat protein kinases: A new twist to an old story. Proceedings of the National Academy of Sciences USA. 113(25):6811-6812. Epub ahead of print Jun 10, 2016. PMCID: PMC4922189 [pdf]

243. Whiting, J.L., Ogier, L., Forbush, K., Bucko, P., Gopalan, J., Seternes, O.M., Langeberg, L.K., and Scott, J.D. (2016) AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proc Natl Acad Sci U S A. 113:E4328-E4337. PMCID: PMC4968721. [pdf] [cover]

244. Newton, A.C., Bootman, M., and Scott, J.D. Second Messengers. In: Sever R, editor. Signal Transductions Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press 2016. pp. 51-64. [pdf]

245. Bjerregaard-Andersen, K., Ostensen, E., Scott, J.D., Tasken, K., and Morth, J.P. (2016) Malonate in the nucleotide-binding site traps human AKAP18gamma/delta in a novel conformational state. Acta Crystallographica F Structural Biology Communications. 72(Pt 8):591-597. PMCID: PMC4973299. [pdf]

246. Kountz, T.S., Lee, K.S., Aggarwal-Howarth, S., Curran, E., Park, J.M., Harris, D.A., Stewart, A., Hendrickson, J., Camp, N.D., Wolf-Yadlin, A., Wang, E.H., Scott, J.D., and Hague, C. (2016) Endogenous N-terminal Domain Cleavage Modulates alpha1D-Adrenergic Receptor Pharmacodynamics. Journal of Biological Chemistry. 291(35):18210-18221. PMCID: PMC5000069. [pdf]

247. Nygren, P. and Scott, J.D. (2016) Regulation of the phosphatase PP2B by protein-protein interactions. Biochemical Society Transactions. 44(5):1313-1319. PMCID: PMC5142753. [pdf]



248. Li, L., Li, J., Drum, B.M., Chen, Y., Yin, H., Guo, X., Luckey, S.W., Gilbert, M., McKnight, G.S., Scott, J.D., Santana, L.F., and Liu, Q. (2017) Loss of AKAP150 promotes pathological remodeling and heart failure propensity by disrupting calcium cycling and contractile reserve. Cardiovascular Research. 113(2):147-159. Epub AOP 17 Nov, 2016. PMCID: PMC5340143 [pdf]

249. Nystoriak, M.A., Nieves-Citrón, M., Patriarchi, T., Buonarati, O.R., Prada, M.P., Morotti, S., Grandi, E., Fernandes, J., Forbush, K., Hofmann, F., Sasse, K.C., Scott, J.D., Ward, S.M., Hell, J.W., and Navedo, M.F. (2017) Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel Cav1.2 and vasoconstriction during acute hyperglycemia and diabetes. Science Signaling. 10:eaaf9647 Epub AOP 24 Jan 2017. PMCID: PMC5297430 [pdf]

250. Aggarwal-Howarth, S. and Scott, J.D. (2017) Pseudoscaffolds and anchoring proteins: the difference is in the details. Biochemical Society Tranactions. 45:371-379. [pdf]

251. Gabrovsek, L., Bucko, P., Carnegie, G.K., and Scott, J.D. A-Kinase Anchoring Protein (AKAP). In: Choi S, editor. Encyclopedia of Signaling Molecules: Springer New York; 2017.  in press.