Our collaborative work on Smoothened-activating cilia oxysterols was published in Molecular Cell!

This work reported cilia-associated oxysterols can activate Hedgehog signaling through Smoothened and inhibition of the formation of such oxysterols can impede Hedgehog pathway activation. This is a multi-institutional collaboration led by David Raleigh and Jeremy Reiter at UCSF. Good job by Kelly on the oxysterol analysis in this work! Check out the paper here and the Cover Art of the issue illustrating findings in this paper.

Our collaborative project on antibiotic resistance was awarded an NIH R01 grant!

Our collaborative project with the Werth lab in the Department of Pharmacy, entitled: “Contribution of altered lipid metabolism to resistance to cell envelope-targeting antimicrobials in MRSA”, was recently awarded a 4-year R01 grant by NIH/NIAID! Congrats to our team members who are key contributors to this project, Kelly Hines, Hideaki Tomita, and Tianwei Shen! We also appreciate earlier support from the School of Pharmacy Faculty Innovation Fund and UW Royalty Research Fund!