We welcome Noelle, Linxi, and Ryan N. to our lab!

We are excited to welcome three Med Chem graduate students to join our lab this year: Noelle Reimers, Linxi Zhu, and Ryan Nguyen! Noelle will work on lipid peroxidation and ferroptosis, Linxi will work on metabolism of benzalkonium chloride, and Ryan will work on the impact of metabolism on human exposome. Can’t wait to see what you will accomplish!

We are awarded an R01 to study the metabolism, transport, and toxicity of benzalkonium chlorides from NIEHS!

In this project, we aim to define the pathways of metabolism and transport of the widely used disinfectant, benzalkonium chlorides (BACs), and elucidate interactions between the metabolism and transport capacity and kidney toxicity of BACs in vitro and in humans. This project involves collaboration with Prof. Allan Rettie at Med Chem and Profs. Joanne Wang, Ed Kelly, and Yvonne Lin at UW Pharmaceutics. Congrats to the team @Ryan @Vanessa @Marie!

Our collaborative work with the Werth lab on S. aureus phospholipid release is published!

We found that the amount and types of released lipids did not correlate with S. aureus survival against daptomycin and that not all agr-deficient S. aureus strains display daptomycin tolerance due to released lipids by the bacteria, in contrast to previous work. Check out the paper below!

Varied Contribution of Phospholipid Shedding From Membrane to Daptomycin Tolerance in Staphylococcus aureus