In this work, we developed a multidimensional database of QACs and QAC metabolites made of retention time, m/z, collision cross section, and MS/MS fragmentation and used it to identify these compounds in human fecal samples. Congratulations, Ryan N. and team! Check out the paper here.
Congratulations to Dr. Vieira in the Joanne Wang’s Lab in the Department of Pharmaceutics and Dr. Ryan Seguin in our lab! We found that short-chain (C8 and C10) BACs are substrates of OCTs and hMATES while all BACs are inhibitors of these transporters using metformin as the probe substrate. Check out the paper here.
Congratulations to Emily, Rutan, Dylan and coauthors! Check out the paper here.
PhD #4 from the lab! Awesome job, Amy! Her thesis title is “Temporal and spatial multi-omics characterization of Smith-Lemli-Opitz syndrome”!
Check out the paper here.
Congrats to Rutan and coauthors! Check out the paper here!
Congrats, Noelle and Team! Check out the paper here.
So proud of you, Quynh! Check out her work on lipid peroxidation mechanisms and ferroptosis:
https://pubs.acs.org/doi/10.1021/acs.joc.0c01920
https://pubs.acs.org/doi/10.1021/jacsau.2c00681
This is a landmark review on the widely used antimicrobials, quaternary ammonium compounds (QACs)! Check it out here.
This paper aims to understand the chemical and biochemical mechanisms underlying the different potency of conjugated and nonconjugated polyunsaturated fatty acids in inducing ferroptosis. Check out the paper here.
