Ryan’s project will focus on characterizing the exposome of ToxCast chemicals using ion mobility-mass spectrometry! Congrats, Ryan! Way to go! Check out the NIEHS-funded EPT training program here.
We are excited to welcome three Med Chem graduate students to join our lab this year: Noelle Reimers, Linxi Zhu, and Ryan Nguyen! Noelle will work on lipid peroxidation and ferroptosis, Linxi will work on metabolism of benzalkonium chloride, and Ryan will work on the impact of metabolism on human exposome. Can’t wait to see what you will accomplish!
This is a collaboration with Prof. Brian Werth in the Department of Pharmacy and Dr. Hari Polenakovik at Wright State U School of Medicine! Check out the paper here. Congrats, Rutan!
In the division for Drug Metabolism and Disposition. Check out the award list here. Good job, Ryan!
Well done, Amy! Check out this work here!
In this project, we aim to define the pathways of metabolism and transport of the widely used disinfectant, benzalkonium chlorides (BACs), and elucidate interactions between the metabolism and transport capacity and kidney toxicity of BACs in vitro and in humans. This project involves collaboration with Prof. Allan Rettie at Med Chem and Profs. Joanne Wang, Ed Kelly, and Yvonne Lin at UW Pharmaceutics. Congrats to the team @Ryan @Vanessa @Marie!
By correlating lipid profile, MIC and time-kill profiles, we found that “Synergy Between Beta-Lactams and Lipo-, Glyco-, and Lipoglycopeptides, Is Independent of the Seesaw Effect in Methicillin-Resistant Staphylococcus aureus“. Congrats, Rutan!
With the support from the Pharmaceutical Sciences Training Program, Marie will examine the kidney toxicity of benzalkonium chlorides using organ-on-a-chip microphysiological system and mass spectrometry imaging! Welcome and Congrats, Marie! What a start!
We found that the amount and types of released lipids did not correlate with S. aureus survival against daptomycin and that not all agr-deficient S. aureus strains display daptomycin tolerance due to released lipids by the bacteria, in contrast to previous work. Check out the paper below!