In this project, we aim to define the pathways of metabolism and transport of the widely used disinfectant, benzalkonium chlorides (BACs), and elucidate interactions between the metabolism and transport capacity and kidney toxicity of BACs in vitro and in humans. This project involves collaboration with Prof. Allan Rettie at Med Chem and Profs. Joanne Wang, Ed Kelly, and Yvonne Lin at UW Pharmaceutics. Congrats to the team @Ryan @Vanessa @Marie!
Congrats to Rutan on his first author paper with the Werth Lab!
By correlating lipid profile, MIC and time-kill profiles, we found that “Synergy Between Beta-Lactams and Lipo-, Glyco-, and Lipoglycopeptides, Is Independent of the Seesaw Effect in Methicillin-Resistant Staphylococcus aureus“. Congrats, Rutan!
Marie Brzoska joins the lab and is awarded a PSTP fellowship!
With the support from the Pharmaceutical Sciences Training Program, Marie will examine the kidney toxicity of benzalkonium chlorides using organ-on-a-chip microphysiological system and mass spectrometry imaging! Welcome and Congrats, Marie! What a start!
Our collaborative work with the Werth lab on S. aureus phospholipid release is published!
We found that the amount and types of released lipids did not correlate with S. aureus survival against daptomycin and that not all agr-deficient S. aureus strains display daptomycin tolerance due to released lipids by the bacteria, in contrast to previous work. Check out the paper below!
Congratulations to Amy on receiving the SOP Graduate Student Leadership Award!
This award recognizes outstanding scientific and/or professional leadership and service as a graduate student! Congrats, Amy! Well deserved! We really appreciate your leadership on various fronts during the pandemic!
Congratulations to Dylan on receiving SOP Outstanding Dissertation Award!
This award is given out to only one thesis per year in the entire School of Pharmacy! Congrats, Dr. Ross! What an achievement!
Congratulations, Dr. Dylan Ross, on a fantastic defense!
Dylan did a spectacular job in defending his thesis! Such an impressive body of work! Congrats, Dr. Ross!
Our review article on characterization of drugs and drug metabolites by IM-MS published in Analytica Chimica Acta!
This paper covers a lot of cool studies in drug and drug metabolites characterization, including some of ours. Check out the paper here.
Josi’s paper on toxicological studies of benzalkonium chloride on neurospheres published at CRT!
Benzalkonium chlorides are a major component of widely used disfectants, such as Lysol and Clorox, which has seen greatly increased usage during COVID-19. This work shed light on the potential neurotoxicity of these compounds. Check out the paper here.
Our collaborative work with Raleigh Lab accepted to JCB!
This work identified Hedgehog signaling negatively regulate DHCR7 and positively regulate CYP7A1, leading to increases in Smo-activating oxysterol levels! Check out this paper here.
