Welcome Amy Li to join the Graduate Program of the Department of Medicinal Chemistry and rotate with us this quarter!
High school teachers from ATHENA workshop visit our lab!
In collaboration with the Center for Exposures, Diseases, Genomics and Environment (EDGE), we recently hosted about 20 high school teachers from around the State of Washington attending the ATHENA Teacher Workshop. Dr. Xu presented on the topic of Vitamins and Health. The teachers then visited our lab to witness techniques involved in biology, organic chemistry, and mass spectrometry! Here is a link to the blog about this event.
We are awarded a pilot grant from UW EDGE funded by NIEHS!
This pilot grant from the UW Center for Exposures, Diseases, Genomics and Environment (EDGE), a NIEHS funded center, will allow us to study the metabolism and disposition of the common environmental chemicals, quaternary ammonium compounds, by human. We really appreciate the support!
Kelly’s paper on calibration of lipid collision cross section was accepted to Analytical Chemistry!
This paper established a set of calibrants for accurate determination of lipid collision cross section using traveling Wave Ion Mobility-Mass Spectrometry, which would serve as the foundation for multi-dimensional lipidomics studies. Congrats, Kelly! Check out this paper here.
Welcome Dylan Ross!
We welcome Dylan joining our lab as a graduate student in Medicinal Chemistry! He is interested in ion mobility-mass spectrometry, molecular modeling, and application of these methodologies in solving biochemical and biological problems.
The antagonistic effect of 7-dehydrocholesterol oxysterols on Hedgehog signaling was published in PNAS!
This collaboration with the laboratory of Dr. Philip Beachy reported identification of 7-dehydrocholesterol-derived oxysterols as antagonists of Hedgehog signaling, specifically 5,8-endoperoxide and DHCEO! Read the paper here.
Libin was appointed as an Adjunct Faculty of the Department of Environmental & Occupational Health Sciences!
Libin was appointed as an Adjunct Assistant Professor of the Department of Environmental & Occupational Health Sciences effective on March 01, 2016.
Our paper on environmental Dhcr7 inhibitors was accepted to Toxicological Sciences!
Congrats to Josi, our former member, Rosalyn Reese, and the rest of the team on their wonderful work! This marks the first paper from our lab at UW! This paper reports the identification of quaternary ammonium compounds as potent inhibitors of Dhcr7, the same enzyme that was affected in SLOS. Check out our publication here.
7-Dehydrocholesterol oxysterols exert differential toxicity to retina-derived cells!
This collaborative work with Dr. Steven Fliesler at SUNY-Buffalo recently published on Experimental Eye Research found that photoreceptor-derived cells are the most sensitive cells to the insult of 7-DHC oxysterols. Check out the paper here.
Quynh Tran joins the lab as a volunteer!
Quynh received her B.S. in Biochemistry in 2015. She will be mostly experiencing different techniques related to neurobiology. Welcome Quynh!