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| Mutagenesis |
| In addition to simulating the DSB formation and rejoining kinetics, the Virtual Cell will output estimates of the expected number of accumulated lethal and non-lethal mutations as a function of time. Here, the term mutation means point mutations as well as larger-scale rearrangements of the DNA (i.e., chromosome aberrations). Illustrative examples of the time-dependent accumulation of lethal mutations as a function of time during and after irradiation are given below. All of the examples are based on representative repair-misrepair (RMR) model parameters for Chinese Hamster Ovary (CHO) cells. | |
Figure 1. Split-dose exposure | Figure 2. External Beam Radiation Treatment (click on figure to enlarge)  |
Figure 3. 125I Brachytherapy | Figure 4. Combined External Beam and |
| School of Health Sciences Purdue University Disclaimer | Last updated: 10 June, 2011 |
