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| DSB Rejoining Kinetics |
| Once the damage formation and repair models have been calibrated, the Virtual Cell can be used to simulate the kinetics of DSB formation and rejoining for any type of radiation exposure scenario. Illustrative examples using repair-misrepair (RMR) model parameters for Chinese Hamster Ovary (CHO) cells are given below. Definition: A strand break (Sb) occurs when a deoxyribose sugar unit or to the phosphate group connecting adjacent deoxyribose sugar units is damaged in a way that effectively cuts one strand of the DNA double helix into two pieces. A double strand break (DSB) occurs when at least one Sb is created in each strand of the DNA double helix within about 10 to 15 base pairs. | |
Figure 1. Split-dose exposure | Figure 2. External Beam Radiation Treatment (click on figure to enlarge)  |
Figure 3. 125I Brachytherapy | Figure 4. Combined External Beam and |
| School of Health Sciences Purdue University Disclaimer | Last updated: 10 June, 2011 |
