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DSB Rejoining Kinetics
Once the damage formation and repair models have been calibrated, the Virtual Cell can be used to simulate the kinetics of DSB formation and rejoining for any type of radiation exposure scenario. Illustrative examples using repair-misrepair (RMR) model parameters for Chinese Hamster Ovary (CHO) cells are given below.

Definition: A strand break (Sb) occurs when a deoxyribose sugar unit or to the phosphate group connecting adjacent deoxyribose sugar units is damaged in a way that effectively cuts one strand of the DNA double helix into two pieces. A double strand break (DSB) occurs when at least one Sb is created in each strand of the DNA double helix within about 10 to 15 base pairs.


Figure 1. Split-dose exposure
(click on figure to enlarge)
DSB per cell during and after a split-dose exposure

Figure 2. External Beam Radiation Treatment
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External beam radiation therapy treatment (2 Gy x 30 days)

Figure 3. 125I Brachytherapy
(click on figure to enlarge)DSB formation and repair during 125I brachytherapy
 

Figure 4. Combined External Beam and
125I Brachytherapy Radiation Treatment

(click on figure to enlarge)
Combined external beam and brachytherapy radiation treatment


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Last updated: 10 June, 2011
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