Greg Crowther

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Student readings

The ability to read and understand the research literature is an important skill, but one whose development requires lots of practice. In order to help my student research assistants develop this skill, I give them occasional study guides, which I have previously found helpful in introducing the literature to naive readers. (More details are available on my Primary literature page.) An archive of reading assignments is presented in the table below.

Date postedAssigned paper and study guide
4/10/12 P.J. Myler et al., "The Seattle Structural Genomics Center for Infectious Disease (SSGCID)," Infectious Disorders - Drug Targets 9: 493-506, 2009. PubMed ID #19594426; study guide.
3/16/12 F.S. Buckner and J.A. Urbina, "Recent developments in sterol 14-demethylase inhibitors for Chagas disease," International Journal for Parasitology: Drugs and Drug Resistance: in press, 2012. preprint; study guide.
11/30/11 H.M. Taylor et al., "The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony," Eukaryotic Cell 9: 37-45, 2010. PubMed ID #19915077; study guide.
8/9/11 J.G. Swoboda et al., "Discovery of a small molecule that blocks wall teichoic acid biosynthesis in Staphylococcus aureus," ACS Chemical Biology 4: 875-83, 2009. PubMed ID #19689117; study guide.
7/25/11 R. Gujjar et al., "Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice," Journal of Medicinal Chemistry 52: 1864-72, 2009. PubMed ID #19296651; study guide.
7/15/11 M.A. Phillips et al., "Triazolopyrimidine-based didhydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum," Journal of Medicinal Chemistry 51: 3649-53, 2008. PubMed ID #18522386; study guide.
2/5/11 M. Rottmann et al., "Spiroindolones, a potent compound class for the treatment of malaria," Science 329: 1175-80, 2010. PubMed ID #20813948; study guide.
11/12/10 J. Baldwin et al., "High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase," Journal of Biological Chemistry 280: 21847-53, 2005. PubMed ID #15795226; study guide.
4/9/10 G.J. Crowther et al., "Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands," Journal of Biomolecular Screening 14: 700-7, 2009. PubMed ID #19470714; study guide.
2/11/10 M. Tamborrini et al., "Design and pre-clinical profiling of a Plasmodium falciparum MSP-3 derived component for a multi-valent virosomal malaria vaccine," Malaria Journal 8: 314, 2009. PubMed ID #20042100; study guide.
1/25/10 I. Faik et al., "Parasite-host interaction in malaria: genetic clues and copy number variation," Genome Medicine 1: 82, 2009. PubMed ID #19725943; study guide.
11/11/09 C. M. Armstrong and D. E. Goldberg, "An FKBP destabilization domain modulates protein levels in Plasmodium falciparum," Nature Methods 4: 1007-9, 2007. PubMed ID #17994030; study guide.
10/7/09 E. T. Larson et al., "Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-luecyl-homophenyl-vinyl sulfone phenyl," Journal of Biological Chemistry 284: 26839-50, 2009. PubMed ID #19596863; study guide.
7/8/09 J. X. Kelly et al., "Discovery of dual function acridones as a new antimalarial chemotype," Nature 459: 270-3, 2009. PubMed ID #19357645; study guide.
6/23/09 C. Aslanidis & P. J. de Jong, "Ligation-independent cloning of PCR products (LIC-PCR)," Nucleic Acids Research 18: 6069-74, 1990. PubMed ID #2235490; study guide.
5/18/09 M. L. Baniecki et al., "High-throughput Plasmodium falciparum growth assay for malaria drug discovery," Antimicrobial Agents and Chemotherapy 51: 716-23, 2007. PubMed ID #17116676; study guide.
3/18/09 T. D. Y. Chung and D. J. Murphy, "Enzyme screens," from Handbook of Drug Screening (R. Seethala and P. B. Fernandes, eds.), 2001. Google Books link; study guide.
2/12/09 M. Vedadi et al., "Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination," Proc. Natl. Acad. Sci. USA 103: 15835-40, 2006. Pub Med ID #17035505; study guide.
1/29/09 S. H. Grossman, "A note on the dual role of glucose in the protection of glucokinase against inactivation," Biochimica et Biophysica Acta 452: 392-7, 1976. PubMed ID #1009116; study guide.