Zombies Versus Trypanosomatids
by Greg Crowther
Lethargic zombie not feeling right:
Itís not your diet; itís a parasite.
Exhausted zombie canít run around.
Trypanosoma has shut you down...
Wake up, zombie -- it's far too early to slip into a reverie.
The Buckner lab is gonna find a drug for late-stage H-A-T.
Infected zombie needing a cure:
Eating brains of others will not save yours.
But C-N-S work demands new tools.
We canít just follow Lipinski rules...
The H in H-A-T stands for Human,
But zombies are a vector too, Iím presuminí...
This is a quasi-punk rock song based somewhat on the efforts of University of Washington professor
Fred Buckner and his team to find compounds that can cure late-stage
Human African Trypanosomiasis (a.k.a. African sleeping sickness), in which T. brucei has invaded the
central nervous system (CNS). As noted in the
lyrics, the famous Lipinski rules for orally bioavailable drugs are not especially useful as predictors of CNS