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| Human Prostate (DU-145) Archive, Prostate |
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Reference: Leith JT, Quaranto L, Padfield G, Michelson S, and Hercbergs A. Radiobiological studies of PC-3 and DU-145 human prostate cancer cells: x-ray sensitivity in vitro and hypoxic fractions of xenografted tumors in vivo. International Journal of Radiation Oncology, Biology, and Physics. 25, 283-287 (1993) Data: Microsoft Excel spreadsheet and as a webpage. DU-145 human prostate carcinoma cells were irradiated by 250 kVp x-rays (dose rate of 60 Gy/hour). Measured data (filled symbols) were digitized from the published figures using UnGraph. The calibrated LPL, RMR, and TLK input files give equally good fits to the measured data as a function of dose and dose rate (solid black lines in the surviving fraction vs. dose plot; see below). The LQ model also provides an adequate fit to the available data. Analysis: |
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| VC Input Files | VC Output Files |
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LQ Model:
An LQ analysis
of the DU-145 data yields point estimates of
a
and a/b
equal to 0.161 Gy-1 and 3.113 Gy, respectively. The 95%
confidence interval for
a/b
is (2.329 Gy, 3.361 Gy). The paired
bootstrap technique for regression (Efron 1979) was used to compute 95%
confidence intervals for the estimated radiosensitivity parameters. Tip: The LQ is a low dose, low dose rate approximation for the LPL and RMR models (see Brenner et al. 1998, Guerrero et al. 2002, Sachs et al. 1997). |
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Click on figure to enlarge |
Click on figure to enlarge |
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Other Cited References
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of Health Sciences Purdue University Disclaimer |
Last updated:
10 June, 2011
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