/*

 REFERENCE:
  Leith JT, Quaranto L, Padfield G, Michelson S, and Hercbergs A. Radiobiological
  studies of PC-3 and DU-145 human prostate cancer cells: x-ray sensitivity in vitro
  and hypoxic fractions of xenografted tumors in vivo. International Journal of
  Radiation Oncology, Biology, and Physics. 25, 283-287 (1993)
PREPARED BY: DAVID CARLSON (djcarlso@purdue.edu))
DATE: 20-NOV-2003
*/

MODEL: DRM=TLK CKM=QECK
CELL: DNA=5.667D+09 NC=46
IRAD: CL=DSB
CLRP: RHT=HT4R BMR=1.2193927E-03 PHI=PML A0=PMR
CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1
RBM: KX=6.0E+06 FMAX=1 !Analysis of PFGE data

! TLK model inputs (simple and complex double strand breaks)
DSB = 30 10 / !Radiation damage to DNA
HT4R = 1.8661711E-01 1.8661711E-01 / !Half-times for DSB repair
PML = 3.4358950E-03 / !Probability a misrejoined DSB is lethal
PMR = 0 0 / !Probability DSB is rejoined correctly

! Parameters that impact on solution accuracy
SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10

! Parameters that control the time steps and stopping criteria
SIMCON: FSDX=1 TSAX=12 TCUT=96 FRDL=1.0D+00 RCUT=1.0D-09

! IRRADIATION CONDITIONS (single fraction)
RADX: ADR=RX1 AD=RX2
RX1 = 60 / !dose rate (Gy/h)
RX2 = 0 0.1 0.25 0.5 1 1.5 2 3 4 5 6 7 8 9 10 12.5 15 17.5 20 25 30 35 /

Last updated: 10 June, 2011
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