VC 2.00J 25-SEP-2003 20-NOV-2003 10:07:12 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\du145.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\du145.radx (6 exposures) XDAT: ..\xdat\du145.xdat (6 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E-02 2.00000E-04 1.2193927E-03 2400 CLRP PHI 0.00000E+00 2.50000E-01 1.00000E-02 3.4358950E-03 2200 CLRP RHT 1.00000E-03 2.40000E+01 6.00000E+00 1.8661711E-01 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 3.20086E-03 (nfom=4490, nsim=26940, nmx=6, nox=6, ndf=2, nap=3) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-3.536E-02 max=2.133E-02, mean=1.5006E-03, stdev=2.0974E-02, var=4.3990E-04 Student's T test (mean=0, NDF=2): Pr>ABS(0.17525)= 8.7702E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.87783)=2.558E-01 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-1.444E-02 max=8.710E-03, mean=6.1263E-04, stdev=8.5625E-03, var=7.3317E-05 Student's T test (mean=0, NDF=2): Pr>ABS(0.17525)= 8.7702E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.87783)=2.558E-01 (passed normality test) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 8.61342E-12 5.29381E-03 30.000000 Complex DSB = 2.87114E-12 1.76460E-03 10.000000 Total DSB = 1.14846E-11 7.05841E-03 40.000000 DAMAGE REPAIR/MISREPAIR: A1= 0.000000E+00 (=0.000%) A2= 0.000000E+00 (=0.000%) PHI1= 3.435895E-03 (=0.344%) PHI2= 3.435895E-03 (=0.344%) (1-A1)*PHI1= 3.435895E-03 (=0.344%) (1-A2)*PHI2= 3.435895E-03 (=0.344%) (1-A1)*(1-PHI1)= 9.965641E-01 (=99.656%) (1-A2)*(1-PHI2)= 9.965641E-01 (=99.656%) RHT1= 0.186617 h (=11.20 minute) RHT2= 0.186617 h (=11.20 minute) LAM1= 3.7142745E+00 (1/h) LAM2= 3.7142745E+00 (1/h) BMR= 1.2193927E-03 (1/h) LAM1/BMR= 3.0460036E+03 LAM2/BMR= 3.0460036E+03 (LAM1+LAM2)/BMR= 6.0920073E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 1.0308E-01 + 3.4359E-02 = 1.3743580E-01 (1/Gy) beta: 4.8568E-02 + 1.6189E-02 = 6.4757402E-02 (1/Gy^2) alpha/beta: 2.1223180 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (DU145 cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 1.5717E-02 9.4300E-01 6.0000E+01 8.20989E-01 1.67E-01 8.30585E-01 1.1553E-02 2 3.3133E-02 1.9880E+00 6.0000E+01 5.88664E-01 1.67E-01 5.97585E-01 1.4929E-02 3 4.9717E-02 2.9830E+00 6.0000E+01 4.04862E-01 1.67E-01 3.91035E-01 -3.5359E-02 4 6.6167E-02 3.9700E+00 6.0000E+01 2.31292E-01 1.67E-01 2.32875E-01 6.7966E-03 5 8.3417E-02 5.0050E+00 6.0000E+01 1.20274E-01 1.67E-01 1.22896E-01 2.1334E-02 6 9.9950E-02 5.9970E+00 6.0000E+01 6.18490E-02 1.67E-01 6.12215E-02 -1.0249E-02 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-3.536E-02 max=2.133E-02, mean=1.5006E-03, stdev=2.0974E-02, var=4.3990E-04 Student's T test (mean=0, NDF=2): Pr>ABS(0.17525)= 8.7702E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.87783)=2.558E-01 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-1.444E-02 max=8.710E-03, mean=6.1263E-04, stdev=8.5625E-03, var=7.3317E-05 Student's T test (mean=0, NDF=2): Pr>ABS(0.17525)= 8.7702E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.87783)=2.558E-01 (passed normality test) NOX=6, NPAR=3 CFE.SF: Cell survival data for DU145 cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 1.5717E-02 9.4300E-01 6.0000E+01 1.79011E-01 8.20989E-01 1.00E+01 2 2 3.3133E-02 1.9880E+00 6.0000E+01 4.11336E-01 5.88664E-01 1.00E+01 3 3 4.9717E-02 2.9830E+00 6.0000E+01 5.95138E-01 4.04862E-01 1.00E+01 4 4 6.6167E-02 3.9700E+00 6.0000E+01 7.68708E-01 2.31292E-01 1.00E+01 5 5 8.3417E-02 5.0050E+00 6.0000E+01 8.79726E-01 1.20274E-01 1.00E+01 6 6 9.9950E-02 5.9970E+00 6.0000E+01 9.38151E-01 6.18490E-02 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (DU145). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 1.572E-02 1.200E+01 4.000E+02 9.4300E-01 2.0917E-01 1.9725E-01 2 2 3.313E-02 1.200E+01 4.000E+02 1.9880E+00 2.6655E-01 5.2990E-01 3 3 4.972E-02 1.200E+01 4.000E+02 2.9830E+00 3.0312E-01 9.0421E-01 4 4 6.617E-02 1.200E+01 4.000E+02 3.9700E+00 3.6878E-01 1.4641E+00 5 5 8.342E-02 1.200E+01 4.000E+02 5.0050E+00 4.2317E-01 2.1180E+00 6 6 9.995E-02 1.200E+01 4.000E+02 5.9970E+00 4.6408E-01 2.7831E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 1.8666 VC 2.00J 25-SEP-2003 20-NOV-2003 10:09:04 PM