Biological X-ray Structure Analysis

Winter Quarter, 2006

University of Washington

Course and Website Description

Biological Structure 515 is a beginning crystallography course offered at the University of Washington since the 1960s. The professors in charge of the course have been Lyle Jensen and Ron Stenkamp . The course covers the basics of X-ray crystallography, including symmetry, lattices, space groups, diffraction, structure solution methods, structure refinement, and structure analysis. The material presented here is a copy of the lecture notes developed over the past few years for the symmetry sections of the course. The material will be updated and refined as time becomes available.

### Class Mechanics

### Basic Questions

### Overview

### Electron Densities and Structure Factors

### The Unit Cell

### Back to the Electron Density Equation

### What Can You Calculate?

### Crystals and Symmetry

### Lattices

### Unit Cells

### Point Groups

### Symmetry and Lattices

### Primitive Bravais Lattices

### Non-Primitive Bravais Lattices

### Possible Point of Confusion - First and Second Settings

### Possible Point of Confusion - Centered Cells and Centers of Inversion

### Certain Types of Non-Primitive Lattices Aren't Considered

### Symmetry Operations in Three-Dimensional Space

### Screw Axes

### Glide Planes

### Space Groups and the International Tables

### Example -

### Meaning of Header Lines in Space Group Entry

### Unit Cell Schematic

### How are Symmetry Elements Denoted?

### What About Equivalent Positions?

### Settings and Systematic Absences

### How Do the New

*Tables*Show Things?### Building from First Principles

### Example - C2/c

### Example - P

### Intersecting Two-Fold Screw Axes

### Diffraction Theory

### Data Collection and Processing

### Structure Solution

### Structure Refinement and Analysis

copyright © Ron Stenkamp stenkamp@u.washington.edu Most recent update 1/9/06