Longitudinal Data Analysis

• Instructors:
  • Garrett Fitzmaurice, Harvard University
  • Patrick Heagerty, University of Washington

• Course Content:
  • Introduction (PJH) -- ***** Notes for Session 1 *****
    • General description of the TLC study
    • Press release about TLC study
    • Background information on chelation

    • TLC Data used to illustrate naive analysis
    • tlc-naive-do.txt -- STATA analysis file for naive analysis

    • NewCFkids.data --- CF example longitudinal data set
    • NewCFkids.txt --- documentation

    • Information on Cystic Fibrosis --- from Mayo Clinic

    • cfkids-do.txt --- STATA code for EDA

  • Mean Models (GF) -- ***** Notes for Session 2 *****
    • Vlagtwedde-Vlaardingen Study

    • Sample SAS Programs and Selected Output

  • Case Study: Dr. Susan Morton

  • Covariance Models (PJH) --- ***** Notes for Session 3 *****

  • Linear Mixed Models (GF) -- ***** Notes for Session 4 *****
    • Menarche Body Fat Accretion Dataset

    • Sample SAS Programs and Selected Output

    • Notes: Analysis of CF Data --- Analysis of CF Data using STATA with "derived variable" and mixed model approaches.
    • cfkids-derived-do.txt --- STATA code for derived variable analysis
    • cfkids-lmm-gee-do.txt --- STATA analysis using mixed models and GEE.

    • Notes: Linear Mixed Models -- SAS --- analysis using SAS, and comparison of different covariance matrices.
    • cfkids-sas.txt --- SAS code for regression analysis
    • NewCFkids-SAS.data --- data to read in to SAS for regression analysis

    • cfkids-CDA-NewLMM.q --- Analysis of CF Data using S+ / R and lme function
    • cfkids-CDA-NewLMM.out --- Analysis output

  • Generalized Estimating Equations (GF) ***** Notes for Session 5 *****
    • Toenail Infection Dataset

    • Sample SAS Programs (for marginal models) and Selected Output

  • Generalized Linear Mixed Models (PJH) ***** Notes for Session 6 *****
    • HivnetWide.raw HIVNET Informed Consent data
    • HivnetWide.txt HIVNET Informed Consent Data -- Documentation

    • Coletti-2003JAIDS.pdf published analysis of knowledge items

    • HivnetIC-glmm-do.txt --- STATA analysis file for conditional logistic regression and GLMM.
    • hivnet-sas.txt --- SAS analysis file for GEE and GLMM.
    • hivnet-lst.txt --- SAS output.

  • Case Study: Dr. Patricia Metcalf

  • Missing Data (GF) ***** Notes for Session 7 *****
    • Clinical Trial of Contracepting Women Dataset

  • Additional Practical Issues (PJH) ***** Notes for Session 8 *****