This page is no longer being updated. For current information on Buckner/Van Voorhis lab meetings, please contact Matt Hulverson (mhulv@uw.edu).
For archival purposes, below is a record of previous lab meetings.
| Date, time, room | Presenter(s) and topic(s) | Snack provider(s) |
|---|
| 6/2/14 |
Ranae Ranade: Trypanosoma brucei methionyl-tRNA synthetase high-throughput screen: selecting lead scaffolds from initial hits |
Fred Buckner |
| 5/19/14 |
Fred Buckner: journal club |
Rob Gillespie |
| 4/7/14 |
Rob Gillespie: progress on compounds for second-stage Human African Trypanosomiasis (HAT) |
K.K. Ojo |
| 3/17/14 |
K.K. Ojo: Human African Trypanosomiasis drug development programs |
Josh McQueen |
| 1/27/14 |
Josh McQueen: structure-activity relationships (SAR) for anti-T. brucei compounds |
Janette Myers |
| 12/9/13 |
Janette Myers: Coenzyme A biosynthesis bifunctional protein (CoaBC) from Mycobacterium tuberculosis |
Ryan Choi |
| 11/4/13 |
Ryan Choi: topoisomerase I from M. tuberculosis |
Wes Van Voorhis |
| 10/7/13 |
Wes Van Voorhis: malaria drug resistance: a hard ACT to follow |
Lynn Barrett |
| 9/9/13 |
Lynn Barrett: VOMPs and circumstance: the case for Variable Outer Membrane Proteins as high-value targets |
Greg Crowther |
| 8/15/13 |
farewell party for Molly, Kate, and Annie |
all (potluck) |
| 7/2/13 |
Greg Crowther: target-based screening in Plasmodium: highly rational, or mostly delusional? |
Matt Hulverson, Wes Van Voorhis |
| 6/3/13 |
Matt Hulverson: CYP51 inhibitors for treatment of Chagas disease; Wes Van Voorhis: report on the BMGF Targets for Malaria Drug Development meeting at MMV |
Fred Buckner |
| 5/6/13 |
Fred Buckner: highlights from "Chagas Week" in Bolivia |
Greg Crowther |
| 4/1/13 |
Cho Yeow Koh: update on the tRNA synthetase literature |
Fred Buckner |
| 3/11/13 |
Jack Jones: bacterial Sec pathway inhibitors; Jack Mo: glucose 6-phosphate dehydrogenase mutations and malaria |
Steve Nakazawa Hewitt |
| 3/4/13 |
Steve Nakazawa Hewitt: lessons on protein rescue from structural genomics projects |
Ethan Merritt |
| 2/4/13 |
Ethan Merritt: do Giardia have an Achilles heel? |
Keyloun/Reid/Yacoob |
| 1/14/13 |
Christina Yacoob: formulation of malaria transmission-blocking compounds;
Kate Keyloun and Molly Reid: CDPKs revisited |
Sharon Creason |
| 1/7/13 |
Sharon Creason: pyrimidine synthesis as a target for antimalarial
drugs and toxicity rescue |
Ranae Ranade |
| 12/3/12 |
Ranae Ranade: identifying real hits from a high-throughput screen |
Rob Gillespie |
| 11/9/12 |
Labby birthday party for Ryan Choi |
July birthday person (Joy Laydbak) |
| 11/5/12 |
Rob Gillespie: non-target-based drug discovery for 2nd-stage HAT |
K.K. Ojo |
| 10/1/12 |
K.K. Ojo: CDPK |
Fred Buckner |
| 8/17/12 |
Farewell party for Alberto Napuli |
Lynn Barrett et al. |
| 8/6/12 |
Fred Buckner: optimization of GNF compounds for treatment of T. brucei infections |
Greg Crowther |
| 7/16/12 |
Joy Laydbak: activation of benznidazol in T. cruzi (PubMed ID #22037852) |
Wes Van Voorhis |
| 7/13/12 |
Labby birthday party for Joy Laydbak |
May birthday people (Greg Crowther, Kasey Rivas) |
| 7/2/12 |
Wes Van Voorhis: using structural genomics to probe essential genes of Burkholderia spp. |
Greg Crowther |
| 6/29/12 |
Farewell party for Mary Nguyen |
Wes Van Voorhis et al. |
| 6/18/12 |
Lynn Barrett: SLU 3.1 building update |
Lynn Barrett; Mary Nguyen |
| 6/8/12 |
Farewell party for Janis Weeks and Anna Fox |
Wes Van Voorhis et al. |
| 6/4/12 |
Anna Fox and Janis Weeks: calcium-dependent protein kinase in Plasmodium |
Matt Hulverson |
| 5/21/12 |
Matt Hulverson: synergistic drug combinations for treatment of T. cruzi |
Greg Crowther |
| 5/11/12 |
Labby birthday party for Greg Crowther and Kasey Rivas |
March birthday person (Lynn Barrett) |
| 5/7/12 |
Greg Crowther: the Plasmodium dUTPase, human glucose 6-phosphate dehydrogenase deficiency,
bacterial protein export, and crowdfunded science |
Ryan Choi, Steve Nakazawa Hewitt |
| 4/4/12 |
Post-NCAA pizza party |
Kasey Rivas |
| 4/2/12 |
Ryan Choi: various approaches to malaria drug discovery; Steve Nakazawa Hewitt: anti-social behavior patterns
(non)expressed by the quorum sensing regulator QteE (PubMed ID #20378835) |
Sharon Creason, Ranae Ranade |
| 3/19/12 |
Sharon Creason: journal club (PubMed IDs 19027798 and 22305482); Ranae Ranade: the long road to high-throughput screening |
K.K. Ojo |
| 3/9/12 |
Labby Birthday party for Lynn Barrett |
February birthday people (Steve Nakazawa Hewitt, Wes Van Voorhis, Ranae Ranade) |
| 3/5/12 |
K.K. Ojo and Christina Yacoob: drug formulation and antimalarials |
Rob Gillespie, Kasey Rivas |
| 2/29/12 |
Farewell party for Steve Johnson |
Wes Van Voorhis et al. |
| 2/17/12 |
Labby Birthday party for Steve Nakazawa Hewitt, Wes Van Voorhis, and Ranae Ranade |
January birthday people (Fred Buckner, Matt Hulverson) |
| 2/6/12 |
Rob Gillespie: adventures with in vitro drug screening;
Kasey Rivas: identifying genetic markers for autism risk |
Fred Buckner |
| 1/23/12 |
Fred Buckner: drug discovery for neglected tropical diseases by academia |
Janis Weeks |
| 1/11/12 |
Janis Weeks (visiting scientist from U. of Oregon): insects, Africa, neurons, music, and nematodes |
Greg Crowther |
| 1/6/12 |
Labby Birthday party for Fred Buckner and Matt Hulverson |
November birthday people (Ryan Choi) |
| 12/19/11 |
Greg Crowther: talking (and singing) to the public about infectious diseases |
Joy Laydbak, Mary Nguyen |
| 12/5/11 |
No meeting due to ASTMH |
| 11/21/11 |
Joy Laydbak: sterol biosynthesis as a Leishmania drug target; Mary Nguyen: Burkholderia
pseudomallei |
Alberto Napuli |
| 11/18/11 |
Labby Birthday party for Ryan Choi |
September birthday people (K.K. Ojo) |
| 11/7/11 |
Alberto Napuli: SSGCID' s viral targets |
Wes Van Voorhis |
| 10/17/11 |
Wes Van Voorhis: Uganda travels with reflections on health needs and our lab's projects |
Fred Buckner |
| 10/3/11 |
Fred Buckner: update on sterol biosynthesis inhibition in T. cruzi |
Matt Hulverson, Angela Gillespie |
| 9/26/11 |
Matt Hulverson: drug synergy in T. cruzi; Angela Gillespie: survey of SSGCID target organisms |
Ryan Choi, Steve Nakazawa Hewitt |
| 9/14/11 |
Ryan Choi: predicting crystallography success from protein recovery screening (PubMed ID #21904040);
Steve Nakazawa Hewitt: principles of scientific illustration |
Lynn Barrett |
| 9/8/11 |
Pizza party |
Fisher Scientific |
| 9/1/11 |
Farwell party for Cassie Bryan |
Lynn Barrett |
| 8/8/11 |
Lynn Barrett: SSGCID analysis of an influenza virus protein; Cassie Bryan: SSGCID purification statistics |
Sharon Creason, Ranae Ranade |
| 8/5/11 |
Workshop on collaborative gastronomy |
Debra Jarvis, Wes Van Voorhis |
| 8/2/11 |
Amy Wernimont and Raymond Hui (from SGC in Toronto): Advances and obstacles in structural biology of protozoan parasites |
N/A |
| 7/29/11 |
Labby Birthday party for Angela Gillespie and Joy Laydbak |
June birthday people (Rob Gillespie) |
| 7/18/11 |
Sharon Creason: in vivo work contributing to a new antimalarial DHODH inhibitor; Ranae Ranade: T. brucei MetRS
inhibition assay for IC50 determination using bioluminescence |
K.K. Ojo |
| 7/8/11 |
Farwell party for David Leibly |
Lynn Barrett |
| 6/24/11 |
Labby Birthday party for Rob Gillespie |
May birthday people (Greg Crowther) |
| 6/20/11 |
David Leibly: E. histolytica cysteine protease 1; K.K. Ojo: T. gondii CDPK1 |
Panqing He |
| 6/6/11 |
Panqing He: use of a YFP variant to monitor movement of T. gondii CDPK1 |
Greg Crowther |
| 5/20/11 |
Labby Birthday party for Greg Crowther |
March birthday people (Lynn Barrett) |
| 5/16/11 |
Greg Crowther: inhibition of the Sec pathway of protein export |
Natascha Mueller |
| 5/2/11 |
Rob Gillespie: Met tRNA synthetase in T. brucei;
David Leibly: solubilization of recombinant proteins via additives during cell lysis |
Rob Gillespie |
| 4/25/11 |
Natascha Mueller: inhibition of CDPK4
and Plasmodium exflagellation |
K.K. Ojo |
| 4/4/11 |
K.K. Ojo: glycogen synthase kinase (GSK) in T. brucei |
Joy Laydbak |
| 3/22/11 |
Joy Laydbak: liver microsomes - how metabolites optimize drug formulation; Paul Newling:
CDK (protein kinase) from Giardia |
Eric Larson |
| 3/21/11 |
Labby Birthday party for Lynn Barrett |
February birthday people (Steve Nakazawa Hewitt, Ranae Pefley, Wes Van Voorhis) |
| 3/16/11 |
Erin Engelson: thesis defense! |
N/A |
| 2/25/11 |
Labby Birthday party for Steve Nakazawa Hewitt, Ranae Pefley, and Wes Van Voorhis |
January birthday people (Fred Buckner, Panqing He, Matt Hulverson) |
| 2/7/11 |
Eric Larson: CDPK1 from T. gondii and C. parvum ... and c-Src from humans |
Alberto Napuli |
| 1/28/11 |
Labby Birthday party for Fred Bucker, Panqing He, and Matt Hulverson |
November birthday people (Ryan Choi) |
| 1/3/11 |
Natalie Grattan: enzyme assay optimization for high-throughput screens |
Alberto Napuli |
| 12/20/10 |
Alberto Napuli |
Janhavi Bhandari, Matt Hulverson |
| 12/6/10 |
Janhavi Bhandari: 3C protease for removal of His tags from proteins;
Matt Hulverson: drug screening of visceral Leishmania |
Fred Buckner |
| 11/22/10 |
Fred Buckner: review of ASTMH annual meeting |
Ryan Choi, Steve Nakazawa Hewitt |
| 11/1/10 |
Ryan Choi: baculovirus expression systems; Steve Nakazawa Hewitt: rescuing proteins by fusing them to MBP |
Cassie Bryan, David Leibly |
| 10/18/10 |
Cassie Bryan: calcium-dependent protein kinase 4 (CDPK4) from P. falciparum;
David Leibly: results of lysis additive screen for SSGCID |
Wes Van Voorhis |
| 10/4/10 |
Wes Van Voorhis: overview of past, present, and future projects |
Sharon Creason, Ranae Pefley |
| 9/20/10 |
Sharon Creason: luciferase-expressing Plasmodium (PubMed ID #18590736);
Ranae Pefley: evaluating anti-T. brucei compounds for penetration through the blood-brain barrier |
Greg Crowther |
| 8/16/10 |
Lynn Barrett: probable move to South Lake Union III; Rob Gillespie: kinetoplastid tRNA synthetases |
Lynn Barrett, Rob Gillespie |
| 8/2/10 |
Greg Crowther: adventures in grant-writing |
Angela Kelley, Natasha Mueller |
| 7/26/10 |
Angela Kelley: cloning and expression of the P. falciparum IMP dehydrogenase; Natascha Mueller: scintillation counting with the MicroBeta2 |
Panqing He |
| 6/21/10 |
Panqing He: assays of the S. mansoni thioredoxin/glutathione reductase and the P. falciparum
protein kinase 6; methylglyoxal metabolism of the tritryps |
K.K. Ojo |
| 6/7/10 |
K.K. Ojo: calcium-dependent protein kinase in Toxoplasma and Cryptosporidium |
Kate Keyloun, Noah Smith |
| 6/3/10 |
Steve Johnson (guest speaker): inhibition of transthyretin amyloidogenesis and GroEL/ES |
Greg Crowther |
| 5/17/10 |
Kate Keyloun: further chemical and genetic validation of GSK3 in T. brucei; Noah Smith: toxicity
screening of compounds active against Leishmania and T. cruzi |
Alberto Napuli |
| 4/26/10 |
Alberto Napuli: highlights from Protein Structure Initiative (PSI) meeting |
Erin Engelson |
| 4/5/10 |
Erin Engelson: trypanosome kinesins |
Janhavi Bhandari, Cassie Bryan, David Leibly |
| 3/15/10 |
Janhavi Bhandari: purification of betaine aldehyde dehydrogenase from Burkholderia pseudomallei;
Cassie Bryan: the E. coli heat shock protein DNAK (HSP70);
David Leibly: lysis additive screen for SSGCID |
Jen Arif, Matt Hulverson |
| 3/1/10 |
Jen Arif and Matt Hulverson: testing of compounds against Leishmania and T. cruzi
in vitro and in vivo, and drug synergy in T. cruzi |
Fred Buckner |
| 2/1/10 |
Fred Buckner: overview of Buckner lab projects |
Rob Gillespie, Steve Nakazawa Hewitt |
| 1/4/10 |
Rob Gillespie: overview of IVIS imaging system; Steve Nakazawa Hewitt: Protein Structure Initiative
(PubMed ID #18356501) |
K.K. Ojo |
| 12/21/09 |
Lab potluck party (note special time) |
Everyone! |
| 12/7/09 |
K.K. Ojo: calcium-dependent protein kinase in T. gondii |
Wes Van Voorhis |
| 11/16/09 |
Wes Van Voorhis: Entamoeba protease drug target project with Sharon Reed |
Lynn Barrett, Sharon Creason |
| 10/19/09 |
Lynn Barrett: permeability testing in mammalian cells; Sharon Creason: efficacy screening in a rodent model of malaria |
Angela Kelley, Natascha Mueller |
| 10/5/09 |
Angela Kelley: cathepsin L in T. gondii (PubMed ID #19596863); Natascha Mueller: PicoGreen assay of Plasmodium growth (PubMed ID #14993620); Fred Buckner: compound database update |
Panqing He |
| 8/17/09 |
Andrew Thomas: activity assays for screening anti-Plasmodium compounds;
Kuzma Kovzun: assaying 6-pyruvoyltetrahydropterin synthase |
Panqing He |
| 8/3/09 |
Panqing He: kinetic and structural studies of hydroxymandelate synthase from Amycolatopsis orientalis |
Janhavi Bhandari |
| 7/20/09 |
Janhavi Bhandari: screening of protein formulation stability (PubMed ID #17107777) |
Greg Crowther |
| 7/6/09 |
Erin Engelson: trypanosome kinesins |
Erin Engelson |
| 6/22/09 |
Phil Rodenbough: high-throughput screening assays of Plasmodium enzymes |
Kate Keyloun |
| 6/8/09 |
Joe Planer: exploring drug synergy for treatment of Chagas disease |
Jen Arif |
| 5/11/09 |
Kate Keyloun: calcium-dependent protein kinase in T. gondii; Jen Arif:
inhibition of T. cruzi sterol 14alpha-demethylase (PubMed ID #19354253 and PubMed ID #19190730) |
Fred Buckner |
| 4/27/09 |
Fred Buckner: tRNA synthetase inhibitors for T. brucei |
Steve Nakazawa Hewitt |
| 4/13/09 |
Steve Nakazawa Hewitt: target-based development of antibacterial drugs (PubMed ID #17159923) |
Phil Rodenbough, Krishna Inampudi |
| 3/9/09 |
Phil Rodenbough: phospholipase A2 inhibitors; Krishna Inampudi: modeling of glycogen synthase kinase in L. major |
Joe Planer |
| 2/23/09 |
Joe Planer: literature review of azoles as anti-Leishmania agents (optional reading:
PubMed ID #10582881) |
Greg Crowther |
| 2/9/09 |
Greg Crowther: buffer optimization of thermal melt assays of Plasmodium proteins |
Rob Gillespie (and Erin Engelson) |
| 1/26/09 |
Erin Engelson: molecular biology of trypanosome kinesins (optional reading: PubMed ID #19043568) |
Fred Buckner |
| 1/12/09 |
Rob Gillespie: glycogen synthase kinase: mutant knock-in experiments in T. brucei |
Fred Buckner |
| 12/15/08 |
Fred Buckner: synergistic drugs in T. cruzi |
Krishna Inampudi, Greg Morlin |
| 11/24/08 |
Krishna Inampudi: structural modeling of non-receptor tyrosine kinases |
KK Ojo |
| 11/10/08 |
KK Ojo: glycogen synthase kinase in T. brucei |
Greg Morlin |
| 10/13/08 |
Greg Morlin: methionine-tRNA synthase |
Lisa Castaneda |
| 9/22/08 |
Lisa Castaneda: protein production and purification (PubMed ID #18235434) |
Jan Schoepe |
| 9/08/08 |
Joe Planer: Leishmania drug screening |
Erin Engelson |
| 8/11/08 |
Greg Crowther: thermal melts of Plasmodium proteins |
Angie Sibounheuang |
| 7/21/08 |
Angie Sibounheuang: N-terminal acetylation and export of Plasmodium proteins into
host erythrocytes (PubMed ID #18534695); farewell party
for Audrey Odom! |
Wes Van Voorhis |
| 7/14/08 |
Jan Schoepe: shikimate pathway enzymes as possible drug targets |
Greg Crowther |
| 6/23/08 |
Erin Engelson: trypanosome lysis by human HDL particles (PubMed ID #18451305); Wes
Van Voorhis: grant proposal on multitarget drugs and docking with dynamics |
Rob Gillespie |
| 6/9/08 |
Rob Gillespie: RNAi targets in T. brucei;
Greg Morlin: methionine-tRNA synthetase assay |
Greg Morlin, Joe Planer |
| 5/12/08 |
Greg Morlin and Joe Planer: resistance to Chagas disease drugs (PubMed ID #18367671) |
Wes Van Voorhis |