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Research

I have done research in the following areas. (For examples and details, please consult my curriculum vitae or PowerPoint slides.)

Science education. I am studying the incorporation of primary literature and content-rich music into science classes.
Selected collaborators: Katie Davis, Becca Price, Wendy Silk
Funding: National Science Foundation

Infectious disease drug development. I use biochemical, biophysical, and bioinformatic methods to assess whether pathogen proteins can be exploited as small-molecule drug targets. Target pathogens include Plasmodium (the cause of malaria) and E. coli.
Selected collaborators: Fernan Aguero, Paul Engel, Erkang Fan, Ron Quinn, Henry Rosen, Seattle Structural Genomics Center for Infectious Disease, Wes Van Voorhis
Funding: Bill & Melinda Gates Foundation, Medicines for Malaria Venture, UW Royalty Research Fund, World Health Organzation

Central metabolism in methylotrophic bacteria. As a postdoctoral fellow, I analyzed the means by which M. extorquens AM1 uses one-carbon substrates like methanol as its sole carbon and energy source.
Adviser: Mary Lidstrom
Funding: National Institutes of Health

Energy metabolism in contracting muscles. As a graduate student, I studied the control of glycolysis, oxidative phosphorylation, and energy use in human leg muscle cells.
Advisers: Kevin Conley and Marty Kushmerick
Funding: National Institutes of Health, National Science Foundation

Sphingolipid metabolism in plants. As an undergraduate, I performed a kinetic characterization of the enzyme sphinganine kinase.
Adviser: Dan Lynch
Funding: Howard Hughes Medical Institute