I have done research in the following areas. (For examples and details, please consult my curriculum vitae or PowerPoint slides.)
STEM education. I am studying the incorporation of primary sources and content-rich music into science, technology, engineering, and math (STEM) courses.
• Selected collaborators: Jennifer Breckler, Katie Davis, Kiki Jenkins, Larry Lesser, Melissa McCartney, Tom McFadden, Becca Price, Wendy Silk
• Funding: National Science Foundation
Infectious disease drug development. I have used biochemical, biophysical, and bioinformatic methods to assess whether specific pathogen proteins can be exploited as small-molecule drug targets. Target pathogens include Plasmodium (the cause of malaria) and E. coli.
• Selected collaborators:
Fernan Aguero, Paul Engel, Erkang Fan, Ron Quinn, Henry Rosen, Seattle Structural Genomics Center for Infectious Disease, Wes Van Voorhis
• Funding: Bill & Melinda Gates Foundation, Medicines for Malaria Venture, UW Royalty Research Fund, World Health Organzation
Central metabolism in methylotrophic bacteria. As a postdoctoral fellow, I analyzed the means by which M. extorquens AM1 uses one-carbon substrates like methanol as its sole carbon and energy source.
• Adviser: Mary Lidstrom
• Funding: National Institutes of Health
Energy metabolism in contracting muscles. As a graduate student, I studied the control of glycolysis, oxidative phosphorylation, and energy use in human leg muscle cells.
• Advisers: Kevin Conley and Marty Kushmerick
• Funding: National Institutes of Health, National Science Foundation
Sphingolipid metabolism in plants. As an undergraduate, I performed a kinetic characterization of the enzyme sphinganine kinase.
• Adviser: Dan Lynch
• Funding: Howard Hughes Medical Institute