In general, my research concerns metabolism --
the set of reactions by which cells extract what they need (chemical energy and
compounds used for growth and repair) from what they have (raw materials or "food").
As an undergraduate, I characterized an individual enzyme (sphinganine kinase)
in plant cells; as a graduate student, I analyzed fluxes through entire pathways (glycolysis
and oxidative phosphorylation) in skeletal muscle cells; and in my initial postdoctoral work,
I investigated how alterations at particular enzymatic steps lead to flux changes at the
whole-pathway level in methylotrophic bacteria.
I am currently interested in the use of drugs to disrupt metabolism
in pathogens such as
the cause of malaria.
As part of this project, I
help maintain TDRtargets.org, an online
database that will expedite the development of new drugs.
A list of my
publications can be found at the end of my
External links relevant to my research