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Polymerase

by Upward Bound students and Greg Crowther


Lyrics

CHORUS:
Polymerase, why canít you be true?
Polymerase, why canít you be true?
You keep making mistakes in the synthesis you do.

I saw a DNA strand growing in size;
Polly was there, adding nucleotides.
Fifty per second, thatís how she rolls;
This little girl is outta control!
Zipping down the template, such a fast pace,
Sooner or later she grabs the wrong base.

CHORUS

The strand is finished, but somethingís wrong;
Itís got an A where a C belongs.
A stop codon thatís premature --
Translation will stop short for sure.
The end result is lean and mean:
A mutated, truncated, bad protein!

CHORUS


Comments

In Chuck Berry's "Maybellene," the title character drives off in a fast car after being unfaithful. In this parody (written with Upward Bound high school students in the summer of 2013), the polymerase (a.k.a. Polly) synthesizes DNA at a reckless rate, causing her replication fidelity to be compromised.