miscellaneous slide

 

 

 

 

 

 

 

 

 

 

Leaving For The Membrane

This parody (written by Greg Crowther) is sung to the tune of "Leaving On A Jet Plane" (written and performed by John Denver).


Lyrics

Well, translation of mRNA
At ribosomes is underway,
And cotranslational transport happens now.
My signal peptide targets me
For binding by the SRP --
Into the ER is where I'm bound...

So decorate my residues --
Glycosylate with sugar groups --
Then pack me into vesicles to go...

I'm leaving for the membrane.
Don't think that I'll be back again --
The cell surface is my home.

Now vesicles from the ER wall
Will carry me through the cytosol
To the Golgi apparatus, cis through trans.
At the Golgi, enzymes wait inside
To tweak my oligosaccharides,
As with the ABO blood antigens...

So decorate my residues --
Glycosylate with sugar groups --
Then pack me into vesicles to go...

I'm leaving for the membrane.
Don't think that I'll be back again --
The cell surface is my home.

I'm leaving for the membrane.
Don't think that I'll be back again --
The cell surface is my home.


Comments

A cell-surface protein summarizes his journey: synthesis at the rough ER, addition of sugar groups in the ER lumen, transfer to the Golgi, further modification of carbohydrate groups there, and ultimate export to the cell membrane.

The SRP mentioned in the first verse is the Signal Recognition Particle, which mediates cotranslational transport of proteins into the endoplasmic reticulum (ER).