Translational Aspects of Computational Neuroscience


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Neurodegenerative Diseases and Compromised Decision Making

 

The existence of discrete swellings along neuronal axon segments, termed focal axonal swellings (FAS), are widely documented in multiple neurodegenerative pathologies including Alzheimer's, Parkinson's, Creutzfeldt-Jakob's, HIV dementia and Multiple Sclerosis. Many studies report cognitive, behavioral, perceptual and sensory-motor impairments coinciding with the presence of FAS, yet until recently, no theoretical framework existed to explain the link between these macro-scale behavioral symptoms and the underlying micro-scale pathology. We have developed one of the first theoretical platforms to address the effects of FAS-driven neurodegeneration and cognitive deficits.

 

Traumatic Brain Injury, Concussions and Cognitive Deficits

 

Focal axonal swellings are also a hallmark feature of concussions and Traumatic Brain Injury (TBI) -- the leading cause of death among youngsters worldwide and a lightning rod issue in contact sports. Further, TBI is the signature injury of the wars in Iraq and Afghanistan, affecting a large percentage of returning veterans. Our theoretical work helps characterize both cognitive deficits and memory loss due to TBI injuries.

 

Introduction to Computational Neurology Tutorials

 

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Computational Neurology: An Introduction

 

This video highlights the area of computational neurology and its broad translational impact for computational neuroscience.
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Computational Neurology: Identifying Critical Regions for Spike Propagation

 

This video highlights how focal axonal swellings impact spike train propagation along the axon.
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Computational Neurology: Compromised Axonal Functionality After Neurodegeneration or TBI

 

This video highlights the effect of FAS on propagation of information along the axon. Specifically, how compromised functionality results.
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Computational Neurology: Computational Toolbox for FAS Diagnostics

 

This video highlights the use of a computational toolbox for evaluating FAS injuries to axons. A MATLAB toolbox is developed that can be used for evaluation.
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Selected Recent Publications

 

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