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Human Prostate (PC-3)
Archive, Prostate

Reference: Algan O, Stobbe CC, Helt AM, Hanks GE, and Chapman JD. Radiation Inactivation of Human Prostate Cancer Cells: The Role of Apoptosis Radiation Research. 146, 267-275 (1996).

Data: Microsoft Excel spreadsheet and as a webpage

PC-3 human prostate carcinoma cells were irradiated by gamma-rays from Cs-137 (dose rate of 84 Gy/hour).  Measured data (filled symbols) were digitized from the published figures using UnGraph.  The calibrated LPL, RMR, and TLK input files give equally good fits to the measured data as a function of dose and dose rate (solid black lines in the surviving fraction vs. dose plot; see below).  The LQ model also provides an adequate fit to the available data.

Analysis:
 
VC Input Files VC Output Files
LQ Model: An LQ analysis of the PC-3 data yields point estimates of a and a/b equal to 0.235 Gy-1 and 3.088 Gy, respectively.  The 95% confidence interval for a/b is (2.218 Gy, 4.150 Gy).  The paired bootstrap technique for regression (Efron 1979) was used to compute 95% confidence intervals for the estimated radiosensitivity parameters.
 

Tip: The LQ is a low dose, low dose rate approximation for the LPL and RMR models (see Brenner et al. 1998, Guerrero et al. 2002, Sachs et al. 1997).

Click on figure to enlarge

Click on figure to enlarge

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Last updated: 10 June, 2011
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