VC 2.00J 25-SEP-2003 19-NOV-2003 11:01:55 AM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\pc3b.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\pc3b.radx (7 exposures) XDAT: ..\xdat\pc3b.xdat (7 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E-02 2.00000E-04 4.5343784E-05 2400 CLRP PHI 0.00000E+00 2.50000E-01 1.00000E-02 1.4764111E-02 2201 CLRP RHT 1.00000E-02 1.20000E+01 1.50000E-01 6.3313587E+00 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 6.90798E-03 (nfom=2951, nsim=20657, nmx=7, nox=7, ndf=3, nap=3) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-6.108E-02 max=8.413E-02, mean=-1.0050E-03, stdev=5.2219E-02, var=2.7268E-03 Student's T test (mean=0, NDF=3): Pr>ABS(0.05092)= 9.6259E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.94846)=7.309E-01 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-2.309E-02 max=3.180E-02, mean=-3.7985E-04, stdev=1.9737E-02, var=3.8955E-04 Student's T test (mean=0, NDF=3): Pr>ABS(0.05092)= 9.6259E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.94846)=7.309E-01 (passed normality test) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 8.61342E-12 5.29381E-03 30.000000 Complex DSB = 2.87114E-12 1.76460E-03 10.000000 Total DSB = 1.14846E-11 7.05841E-03 40.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 1.476411E-02 (=1.476%) PHI2= 1.476411E-02 (=1.476%) (1-A1)*PHI1= 3.691028E-03 (=0.369%) (1-A2)*PHI2= 1.107308E-02 (=1.107%) (1-A1)*(1-PHI1)= 2.463090E-01 (=24.631%) (1-A2)*(1-PHI2)= 7.389269E-01 (=73.893%) RHT1= 6.331359 h (=379.88 minute) RHT2= 7.000000 h (=420.00 minute) LAM1= 1.0947842E-01 (1/h) LAM2= 9.9021026E-02 (1/h) BMR= 4.5343784E-05 (1/h) LAM1/BMR= 2.4144086E+03 LAM2/BMR= 2.1837839E+03 (LAM1+LAM2)/BMR= 4.5981925E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 1.1073E-01 + 1.1073E-01 = 2.2146166E-01 (1/Gy) beta: 6.1736E-02 + 2.1300E-02 = 8.3036061E-02 (1/Gy^2) alpha/beta: 2.6670540 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (PC3B cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 2.7778E-13 0.0000E+00 0.0000E+00 9.99941E-01 1.43E-01 1.00000E+00 5.9000E-05 2 1.1893E-02 9.9900E-01 8.4000E+01 7.82405E-01 1.43E-01 7.37365E-01 -6.1082E-02 3 2.3821E-02 2.0010E+00 8.4000E+01 4.55533E-01 1.43E-01 4.62551E-01 1.5173E-02 4 3.5702E-02 2.9990E+00 8.4000E+01 2.28105E-01 1.43E-01 2.49059E-01 8.4131E-02 5 4.7631E-02 4.0010E+00 8.4000E+01 1.17650E-01 1.43E-01 1.15133E-01 -2.1866E-02 6 5.9595E-02 5.0060E+00 8.4000E+01 4.86160E-02 1.43E-01 4.58834E-02 -5.9556E-02 7 7.1524E-02 6.0080E+00 8.4000E+01 1.53510E-02 1.43E-01 1.59260E-02 3.6106E-02 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-6.108E-02 max=8.413E-02, mean=-1.0050E-03, stdev=5.2219E-02, var=2.7268E-03 Student's T test (mean=0, NDF=3): Pr>ABS(0.05092)= 9.6259E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.94846)=7.309E-01 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-2.309E-02 max=3.180E-02, mean=-3.7985E-04, stdev=1.9737E-02, var=3.8955E-04 Student's T test (mean=0, NDF=3): Pr>ABS(0.05092)= 9.6259E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.94846)=7.309E-01 (passed normality test) NOX=7, NPAR=3 CFE.SF: Cell survival data for PC3B cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 2.7778E-13 0.0000E+00 0.0000E+00 5.90000E-05 9.99941E-01 1.00E+01 2 2 1.1893E-02 9.9900E-01 8.4000E+01 2.17595E-01 7.82405E-01 1.00E+01 3 3 2.3821E-02 2.0010E+00 8.4000E+01 5.44467E-01 4.55533E-01 1.00E+01 4 4 3.5702E-02 2.9990E+00 8.4000E+01 7.71895E-01 2.28105E-01 1.00E+01 5 5 4.7631E-02 4.0010E+00 8.4000E+01 8.82350E-01 1.17650E-01 1.00E+01 6 6 5.9595E-02 5.0060E+00 8.4000E+01 9.51384E-01 4.86160E-02 1.00E+01 7 7 7.1524E-02 6.0080E+00 8.4000E+01 9.84649E-01 1.53510E-02 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (PC3B). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 2.778E-13 1.200E+01 4.000E+02 0.0000E+00 0.0000E+00 0.0000E+00 2 2 1.189E-02 1.200E+01 4.000E+02 9.9900E-01 2.4563E-01 2.4538E-01 3 3 2.382E-02 1.200E+01 4.000E+02 2.0010E+00 3.9295E-01 7.8629E-01 4 4 3.570E-02 1.200E+01 4.000E+02 2.9990E+00 4.9281E-01 1.4779E+00 5 5 4.763E-02 1.200E+01 4.000E+02 4.0010E+00 5.3488E-01 2.1400E+00 6 6 5.960E-02 1.200E+01 4.000E+02 5.0060E+00 6.0404E-01 3.0238E+00 7 7 7.152E-02 1.200E+01 4.000E+02 6.0080E+00 6.9517E-01 4.1766E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 1.9304 VC 2.00J 25-SEP-2003 19-NOV-2003 11:03:51 AM