Ron Stenkamp's Homepage - Crystallography and Molecules

Overview

I'm a professor in the Department of Biological Structure at the University of Washington. My research and teaching activities are centered on the structure and function of biological macromolecules with a strong dependence on X-ray crystallographic techniques for studying molecular structures. I particularly enjoy the mix of experimental and computational work associated with crystallography and the great dependence on geometry in this type of research.

Teaching Projects

Biological X-ray Structure Analysis - Biological Structure 515

This introductory course covers the fundamentals of crystals (lattices, unit cells, symmetry, space groups), diffraction (optical analogs, Laue conditions, Bragg's Law, Ewald's sphere of reflection), structure solution (direct methods, Patterson techniques, multiple isomorphous replacement, molecular replacement, MAD), and refinement. I will gradually collect my lecture notes and problem sets and bring them up on the Web so what's there now is only a start.

Research Projects

• G-Protein-Coupled Receptors
  Rhodopsin - co-investigators - Dave Teller, Isolde Le Trong, Craig Behnke, Brian Fox, and Kris Palczewski
• Cellular Retinaldehyde-Binding Protein
  CRALBP - co-investigators - Dave Teller , Jack Saari , Ram Samudrala and Tianyun Liu
• Blood-Proteins (on hold)
  Factor XIII - co-investigators - Dave Teller, Vivien Yee, Isolde Le Trong, Richard Garzon, Craig Behnke, and Brian Fox
• Protein-Ligand Interactions
  Streptavidin - co-investigators - Pat Stayton , Isolde Le Trong, and Stefanie Freitag
• Metalloproteins (on hold)
  Hemerythrin
  Rubredoxin
• Drug Detoxication Enzymes
  Glutathione S-transferase - co-investigators - Ellie Adman, Isolde Le Trong, Bill Atkins
  Cytochrome P450 - co-investigators - Rheem Totah, Isolde Le Trong.
  
• Cell Adhesion Proteins
  Fimbria - co-investigators - Evgeni Sokurenko, Pavel Aprikian, Isolde Le Trong, Wendy Thomas
  DraE - co-investigators - Steve Moseley, Natalia Korotvkova, Isolde Le Trong
  
• Transcription Regulators
  SlyA - co-investigators - Steve Libby, Peter Brzovic, Isolde Le Trong.
  
• Other Proteins
  COMT - co-investigators - Bill Parson, Isolde Le Trong, Karen Rutherford.
  BRCA1 - co-investigators - Rachel Klevit, Isolde Le Trong, David Fox.
  
  

  Official University Connections

  Protein structure and function research has historically been a leading example of interdisciplinary research located somewhere between chemistry, biology and physics. At the University of Washington, interdisciplinary studies have been supported by the overlaying of various centers and programs over the traditional departmental disciplines. Accordingly, I'm associated with several academic units at the UW.

  • Dept. of Biological Structure
  • Dept. of Chemistry
  • Dept. of Biochemistry
  • Biomolecular Structure Center
  • Biomolecular Structure and Design Program
  • Molecular and Cellular Biology Program

  Biographical Sketch

  • Curriculum Vitae
  • Publications

  Contact Information

  Mailing address:
  Box 357420
  Dept. of Biological Structure
  University of Washington
  Seattle, WA 98195-7420
  
  phone: (206) 685-1721
  FAX: (206) 543-1524
  E-mail: stenkamp@u.washington.edu

  copyright © Ron Stenkamp Most recent update 10/7/08

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