Ron Stenkamp's Homepage - Crystallography and Molecules
I'm a professor in the Departments of Biological Structure and Biochemistry at the University of Washington. My research and teaching activities are centered on the
structure and function of biological macromolecules with a strong dependence on X-ray
crystallographic techniques for studying molecular structures. I particularly enjoy the
mix of experimental and computational work associated with crystallography and the great dependence on geometry in this type of research.
This introductory course covers the fundamentals of crystals (lattices, unit cells, symmetry, space groups), diffraction (optical analogs, Laue conditions, Bragg's Law, Ewald's sphere of reflection), structure solution (direct methods, Patterson techniques, multiple isomorphous replacement, molecular replacement, MAD), and refinement.
The course content and organization is being revised (2012), and the course website will be revised when possible.
My group collaborates with many others to provide crystal structures of molecules of biochemical interest.
Listed here are proteins of past and present interest, along with links to websites
describing some of the molecules and projects in more detail. Current and past collaborators are also listed here.
Rhodopsin - co-investigators -
Kris Palczewski, Dave Teller.
Streptavidin - co-investigators -
Pat Stayton, Terry Lybrand.
Drug Detoxication Enzymes
Glutathione S-transferase - co-investigators -
Bill Atkins, Michele Scian.
Cytochrome P450 - co-investigators -
Rheem Totah, Bill Atkins.
Cell Adhesion Proteins
Fimbria - co-investigators -
Evgeni Sokurenko, Wendy Thomas.
DraE - co-investigator -
Steve Moseley, Natalia Korotkova.
SlyA - co-investigators - Steve Libby, Peter Brzovic.
Other Proteins and Peptides
COMT - co-investigator -
BRCA1 - co-investigator -
Type VI Secretion System Proteins - co-investigator - Joseph Mougous.
Aldehyde dehydrogenase - co-investigators - John Amory, Jisun Paik, Alex Goldstein, Nina Isoherranen.
Trp cages - co-investigators - Niels Andersen, Michele Scian.
Pectin methylesterase - co-investigators - Jerry Reeck, Dave Teller.
Cellular Retinaldehyde-Binding Protein
CRALBP - co-investigators -
Jack Saari, Dave Teller, Ram Samudrala.
Blood-Proteins (on hold)
Factor XIII - co-investigators -
Dave Teller, Earl Davie.
Dept. of Biological Structure
University of Washington
Seattle, WA 98195-7420
phone: (206) 685-1721
FAX: (206) 543-1524
copyright © Ron Stenkamp
Most recent update 12/29/2014