mt rainier

Research Publications

Divergent neural circuits for proprioceptive and exteroceptive sensing of the Drosophila leg.
Su-Yee J Lee, Chris J Dallmann, Andrew Cook, John C Tuthill, Sweta Agrawal
biorxiv 2024. PDF, Supplement

Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking.
Lili Karashchuk, Jing Shuang Lisa Li, Grant M Chou, Sarah Walling-Bell, Steven L Brunton, John C Tuthill, Bingni W Brunton
biorxiv 2024. PDF, Supplement

Miniature linear and split-belt treadmills reveal mechanisms of adaptive motor control in walking Drosophila.
Brandon Pratt, Su-Yee Lee, Grant Chou, John C Tuthill
biorxiv 2024. PDF, Supplement

Presynaptic inhibition selectively suppresses leg proprioception in behaving Drosophila.
Chris J. Dallmann, Sweta Agrawal, Andrew Cook, Bingni W.Brunton, John C.Tuthill
biorxiv 2023. PDF, Supplement

Snow flies self-amputate freezing limbs to sustain behavior at sub-zero temperatures.
Dominic Golding, Katie L. Rupp, Anne Sustar, Brandon Pratt, and John C. Tuthill
Current Biology 2023. PDF, Code, and Data

Biomechanical origins of proprioceptor feature selectivity and topographic maps in the Drosophila leg
Akira Mamiya, Anne Sustar, Igor Siwanowicz, Yanyan Qi, Tzu-Chiao Lu, Pralaksha Gurung, Chenghao Chen, Jasper S. Phelps, Aaron T. Kuan, Alexandra Pacureanu, Wei-Chung Allen Lee, Hongjie Li, Natasha Mhatre, and John C. Tuthill
Neuron 2023. PDF, Data , and Code

Adult Drosophila legs do not regenerate after amputation: Comment on 'A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice'
Anne Sustar, John C Tuthill
eLife 2023. PDF , Authors' Response

BKinD-3D: Self-Supervised 3D Keypoint Discovery from Multi-View Videos.
Jennifer J Sun, Lili Karashchuk, Amil Dravid, Serim Ryou, Sonia Fereidooni, John C Tuthill, Aggelos Katsaggelos, Bingni W Brunton, Georgia Gkioxari, Ann Kennedy, Yisong Yue, and Pietro Perona
Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) 2023. PDF, Code, Supplement , and Website

Synaptic architecture of leg and wing motor control networks in Drosophila.
Ellen Lesser, Anthony W. Azevedo, Jasper S. Phelps, Leila Elabbady, Andrew P. Cook, Brandon Mark, Sumiya Kuroda, Anne Sustar, Anthony J. Moussa, Chris J. Dallmann, Sweta Agrawal, Su-Yee J. Lee, Brandon G. Pratt, Kyobi Skutt-Kakari, Stephan Gerhard, Ran Lu, Nico Kemnitz, Kisuk Lee, Akhilesh Halageri, Manuel Castro, Dodam Ih, Jay Gager, Marwan Tammam, Sven Dorkenwald, Forrest C. Collman, Casey M Schneider-Mizell, Derrick Brittain, Chris S Jordan, H Sebastian Seung, Thomas Macrina, Michael H Dickinson, Wei-Chung Allen Lee, and John C. Tuthill
bioRxiv 2023.06.01. PDF

Tools for comprehensive reconstruction and analysis of Drosophila motor circuits.
Anthony Azevedo, Ellen Lesser, Brandon Mark, Jasper Phelps, Leila Elabbady, Sumiya Kuroda, Anne Sustar, Anthony Moussa, Avinash Kandelwal, Chris J. Dallmann, Sweta Agrawal, Su-Yee J. Lee, Brandon Pratt, Andrew Cook, Kyobi Skutt-Kakaria, Stephan Gerhard, Ran Lu, Nico Kemnitz, Kisuk Lee, Akhilesh Halageri, Manuel Castro, Dodam Ih, Jay Gager, Marwan Tammam, Sven Dorkenwald, Forrest Collman, Casey Schneider-Mizell, Derrick Brittain, Chris S. Jordan, Michael Dickinson, Alexandra Pacureanu, H. Sebastian Seung, Thomas Macrina, Wei-Chung Allen Lee, John C. Tuthill
bioRxiv 2022.10.25.513553 PDF

The evolutionary trajectory of drosophilid walking
Ryan A. York, Luke E. Brezovec, Jenn Coughlan, Steven Herbst, Avery Krieger, Su-Yee Lee, Brandon Pratt, Ashley D. Smart, Eugene Song, Anton Suvorov, Daniel R. Matute, John C. Tuthill, Thomas R. Clandinin.
Current Biology 2022. PDF

Functional architecture of neural circuits for leg proprioception in Drosophila.
Chen C, Agrawal S, Mark B, Mamiya A, Sustar A, Phelps J, Lee WCA, Dickson B, Card G, Tuthill JC.
Current Biology 2021. PDF , Data

Anipose: a toolkit for robust markerless 3D pose estimation.
Karashchuk P, Rupp KL, Dickinson ES, Sanders E, Azim E, Brunton BW, Tuthill JC
Cell Reports 2021. PDF, Tutorials, Code, Visualizer, and Data

Reconstruction of motor control circuits in adult Drosophila using automated transmission electron microscopy.
Phelps J, Hildebrand DGC, Graham BJ, Kuan AT, Thomas, LA, Nguyen T, Buhmann J, Azevedo AW, Sustar A, Agrawal S, Liu M, Shanny BL, Funke J, Tuthill JC, Lee WCA
Cell 2021. PDF , Data

Central processing of leg proprioception in Drosophila.
Agrawal S, Dickinson ES, Sustar A, Gurung P, Shepherd D, Truman J, Tuthill JC
eLife 2020. PDF, Data

Dense neuronal reconstruction through X-ray holographic nano-tomography.
Kuan AT, Phelps J, Thomas LA, Nguyen TM, Han J, Chen CL, Azevedo AW, Tuthill JC, Funke J, Cloetens P, Pacureanu A, Lee WCA
Nature Neuroscience 2020. PDF, Data

A systematic nomenclature for the Drosophila ventral nerve cord.
Court RC, Namiki S, Armstrong JD, Borner J, Card G, Costa M, Dickinson MH, Duch C, Korff W, Mann R, Merritt D, Murphey R, Seeds A, Shirangi T, Simpson J, Truman J, Tuthill JC, Williams D, Shepherd D
Neuron 2020. PDF

A size principle for recruitment of Drosophila leg motor neurons.
Azevedo AW, Dickinson ES, Gurung P, Venkatasubramanian L, Mann R, Tuthill JC
eLife 2020. PDF, Data , and Code

Neural coding of leg proprioception in Drosophila.
Mamiya A, Gurung P, Tuthill JC
Neuron 2018. PDF, Supplement, Data

Microtubule acetylation is required for mechanosensation in Drosophila.
Yan C, Wang F, Peng Y, Williams CR, Jenkins B, Wildonger J, Kim HJ, Perr JB, Vaughan JC, Kern ME, Falvo MR, O'Brien ET 3rd, Superfine R, Tuthill JC, Xiang Y, Rogers SL, Parrish JZ.
Cell Reports 2018. PDF

Review Articles

Commentary Articles

Pre-Tuthill Lab

Parallel transformation of tactile signals in central circuits of Drosophila.
Tuthill JC and Wilson RI
Cell 2016 164(5):1046-1059. PDF

Wide-field feedback neurons dynamically tune early visual processing.
Tuthill JC, Nern A, Rubin GM, Reiser MB
Neuron 2014 82(4):887-95. PDF

Contributions of the 12 neuron classes in the fly lamina to motion vision.
Tuthill JC, Nern A, Holtz SL, Rubin GM, Reiser MB
Neuron 2013 79(1):128-40.  PDF

Neural correlates of illusory motion perception in Drosophila.
Tuthill JC, Chiappe ME, Reiser MB
PNAS 2011 108(23):9685-90.  PDF

Physiology and morphology of sustaining and dimming neurons of the crab Chasmagnathus granulatus (Brachyura: Grapsidae).
Beron de Astrada M, Tuthill JC, Tomsic D
J Comp Physiol A 2009 195(8):791-8.  PDF
Patterns of transmission ratio distortion in monkeyflower (Mimulus) hybrids reveal a complex genetic basis for conspecific pollen precedence.
Fishman L, Aagaard J, Tuthill JC
Evolution 2008 62(12):2958-70. PDF

Polarization sensitivity in the red swamp crayfish Procambarus clarkii enhances the detection of moving transparent objects.
Tuthill JC, Johnsen S
J Exp Biol 2006 209(9):1612-6. PDF