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| Human Prostate (LNCaP) Archive, Prostate |
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Reference: Deweese TL, Shipman JM, Dillehay LE, and Nelson WG. Sensitivity of human prostatic carcinoma lines to low dose rate radiation exposure. Journal of Urology. 159, 591-598 (1998). Data: Microsoft Excel spreadsheet and as a webpage. LNCaP human prostate carcinoma cells were irradiated by gamma-rays from Cs-137 (dose rates of 0.25 and 60 Gy/hour). Measured data (filled symbols) were digitized from the published figures using UnGraph. The calibrated LPL, RMR, and TLK input files give equally good fits to the measured data as a function of dose and dose rate (solid black lines in the surviving fraction vs. dose plot; see below). The LQ model also provides an adequate fit to the available data. Analysis: |
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| VC Input Files | VC Output Files |
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LQ Model:
An LQ analysis
of the LNCaP data yields point estimates of
a
and a/b
equal to 0.351 Gy-1 and 1.086 Gy, respectively. The 95%
confidence interval for
a/b
is (1.056 Gy, 1.361 Gy). The point estimate for the repair half-time is
0.011 h, and the 95% confidence interval is (0.011 h, 0.014 h). The paired
bootstrap technique for regression (Efron 1979) was used to compute 95%
confidence intervals for the estimated radiosensitivity parameters. Tip: The LQ is a low dose, low dose rate approximation for the LPL and RMR models (see Brenner et al. 1998, Guerrero et al. 2002, Sachs et al. 1997). |
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Click on figure to enlarge |
Click on figure to enlarge |
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Other Cited References
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of Health Sciences Purdue University Disclaimer |
Last updated:
10 June, 2011
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