SISMID 2013 Module 8 on Evaluation of Immune Correlates of Protection

Instructors: Ivan Chan, Peter Gilbert, Paul T. Edlefsen, Ying Huang

Session 1 Slides on Introduction to Vaccines

• Introduction to Vaccines: Session 1

Session 2 Slides on Introduction to Evaluating an Immunological Correlate of Protection

• Introduction to Immune Correlates of Protection: Session 2

Session 3 Slides on Evaluating Correlates of Protection Using Individual, Population, and Titer-Specific Approaches

• Evaluating CoPs: Session 3

Session 4 Slides on Evaluating an Immunological Correlate of Risk

• Evaluating a CoR: Session 4
• Evaluating a CoR: Session 4 Long Version

Session 5 Slides on Use of Statistical Models in Assessing Correlates of Protection

• Evaluating CoPs with Models: Session 5

Session 6 Slides on Introduction to Sieve Analysis

• Intro to Sieve Analysis Part I: Session 6
• Intro to Sieve Analysis Part II: Session 6

Session 7 Slides on Thai Trial Case Study

• Thai Trial Case Study: Session 7

Session 8 Slides on Validation Using Prentice Criteria and Causal Inference Framework, Design Considerations

• Evaluating CoPs with Prentice Criteria and Causal Inference: Session 8

Session 9 Slides on Evaluating a Specific Surrogate of Protection Part I

• Evaluating a Specific Surrogate Part I: Session 9

Session 10 Slides on Evaluating a Specific Surrogate of Protection Part II

• Evaluating a Specific Surrogate Part II: Session 10

References for Module 8

• Bibliography for Immune Correlates Module 8

Data Set

• HIV Vaccine Efficacy Trial Dataset
• Dataset Documentation

Computer Code

• R code implementing cch Borgan estimator II, Breslow et al. (2009, AJE), and Gilbert and Hudgens (2008, Biometrics)