Principle Investigator

Kim A. Woodrow, Ph.D.
Assistant Professor of Bioengineering
W.H. Foege N410D
3720 15th Avenue NE
Seattle, WA 98122-5061
206 685 6831 (phone)
email:

Program Operations Specialist

Patricia Foster
Mon - Fri 8:00 a.m. - 12:00 noon

206 685 3581 (phone)
email:


Research Scientists & Postdoctoral Scholars

Shih-Feng Chou, Ph.D.
Senior Fellow, 2014 - current
Postdoctoral Scientist, Thayer School of Engineering, Dartmouth, 2013
Ph.D., Materials Engineering, Auburn University, 2011
M.S., Mech. Eng., Southern Illinois University Carbondale, 2005
B.S., Mechanical Engineering, National Chiao-Tung University, 2001
email:

Yonghou Jiang, D.V.M., Ph.D.
Research Scientist, 2013 - current
Research Scientist, Washington National Primate Research Center, 2013
Postdoctoral Scientist, Pathobiology, University of Washington, 2006
Vistiting Scientist, Washington National Primate Research Center, 2003
Ph.D., Veterinary Pathology, NEAU College of Veterinary Medicine, 2000
M.S., Infectious Disease, NEAU College of Veterinary Medicine, 1995
D.V.M., Veterinary Medicine, NEAU College of Veterinary Medicine, 1992
email:

Huarong Nie, Ph.D.
Senior Fellow, 2013 - current
Postdoctoral Scientist, Polymer Sci. & Eng., Univ. of Mass., Amherst, 2013
Ph.D., Polymer Physics & Chemistry, Chinese Academy of Sciences, 2009
B.S., M.S., Polymer Physics & Chemistry, Lanzhou University, 2004
email:

Jaehyung Park, Ph.D.
Research Scientist, 2013 - current
Postdoctoral Scientist, Bioengineering, University of Washington, 2012
Ph.D., Biomedical Engineering, Georgia Institute of Technology, 2009
M.S., Chemical Engineering, Tufts University, 2004
M.S., Materials Science & Engineering, Korea Aerospace University, 1998
B.S., Materials Science & Engineering, Korea Aerospace University, 1996
email:

Graduate Students

Cameron Ball
Graduate Student, Bioengineering, 2010 - current
B.S., Biomedical Engineering, Washington University
NSF Graduate Research Fellow
email:

Anna Blakney
Graduate Student, Bioengineering, 2012 - current
B.S., Chemical Engineering, University of Colorado, Boulder
NSF Graduate Research Fellow
Molecular Medicine Training Fellow
email:

Shijie Cao
Graduate Student, Bioengineering, 2013 - current
B.S., Pharmacy, Fudan University
email:

More Information

Research focus:
Nanoparticle-based drug delivery for prevention and treatment of HIV


Presentations:

  • 1. Gao Huile, Pan Shuaiqi, Yang Zhi, Cao Shijie, Chen Chen, Jiang Xinguo,etc. A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EFG1 protein. Biomaterials. 32 (2011) 8669-8675
  • 2.Huile Gao, Zhiqing Pang, Shuaiqi Pan, Shijie Cao, Zhi Yang, Chen Chen, and Xinguo Jiang. Anti-glioma Effect and Safety of Docetaxel-loaded Nanoemulsion. Arch Pharm Res, 2012 Vol 35, No 2, 333-341
  • 3. Huile Gao1, Jun Qian1, Shijie Cao, Zhi Yang, Zhiqing Pang, Shuaiqi Pan, Li Fan, Zhangjie Xi, Xinguo Jiang, Qizhi Zhang*. Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles. Biomaterials 33 (2012) 5115-5123
  • 4. Huile Gao1, Jun Qian1, Zhi Yang, Zhiqing Pang, Zhangjie Xi, Shijie Cao, Yuchen Wang, Shuaiqi Pan,Shuang Zhang, Wei Wang, Xinguo Jiang, Qizhi Zhang*. Whole-cell SELEX aptamer-functionalised poly(ethyleneglycol)-poly(ε-caprolactone) nanoparticles for enhanced targeted glioblastoma therapy. Biomaterials, 33 (2012) 6264-6272
  • 5. Huile Gao, Zhi Yang, Shijie Cao, Zhangjie Xi, Zhang Shuang, Pang Zhiqing, Jiang Xinguo. Behavior and anti-glioma effect of lapatinib-incorporated lipoprotein-like nanoparticles. Nanotechnology, 23(2012), 435101
  • 6. Huile Gao, Shilei Cao, Chen Chen, Shijie Cao, Zhi Yang, Zhiqing Pang, Zhangjie Xi, Shuaiqi Pan, Zhiqing Pang, Xinguo Jiang. Incorporation of lapatinib into lipoprotein-like nanoparticles with enhanced water solubility andanti-breast cancer effect. Nanomedicine(UK), 2013, Vol.8, No.9, 1429-1442
  • 7. Huile Gao, Zhi Yang, Shuang Zhang, Shijie Cao, Shun Shen, Zhiqing Pang, Xinguo Jiang.Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization[J]. Scientific reports, 2013, 3.
  • 8. Gao H, Yang Z, Zhang S, Cao S, Pang Z, Yang X, Jiang X. Glioma-homing peptide with a cell-penetrating effect for targeting delivery with enhanced glioma localization, penetration and suppression of glioma growth. J Control Release. 2013, 172(3) : 921-928
  • 9. Gao H, Yang Z, Cao S, Xiong Y, Zhang S, Pang Z, Jiang, X. Tumor cells and neovasculature dual targeting delivery for glioblastoma treatment[J]. Biomaterials, 2014, 35(7): 2374-2382.
  • 10. Huile Gao, Yang Xiong, Shuang Zhang, Zhi Yang, Shijie Cao, Xinguo Jiang. RGD and interleukin-13 peptide functionalized nanoparticles for enhanced glioblastoma cells and neovasculature dual targeting delivery and elevated tumor penetration[J]. Molecular pharmaceutics, 2014, 11(3): 1042-1052.
  • 11. Huile Gao, Shuang Zhang, Zhi Yang, Shijie Cao, Xinguo Jiang, Zhiqing Pang. In vitro and in vivo intracellular distribution and anti-glioblastoma effects of docetaxel-loaded nanoparticles functioned with IL-13 peptide[J]. International journal of pharmaceutics, 2014, 466(1): 8-17.


Honors and Awards:

  • Wangdao Scholar, Fudan University(2011-2013); Renmin Scholarship, Fudan University (2011); Xu Zengshou Scholarship, Funda University (2010)

Emily Krogstad
Graduate Student, Bioengineering, 2010 - current
B.S., Biomedical Engineering, University of Minnesota
NSF Graduate Research Fellow
email:

More Information

Research focus:
Nanomaterials for STI prevention (nanoparticles and electrospun nanofibers), vaginal drug delivery.

Publications:

    • 1. Tang, R., Palumbo, N., Nagarajan, L., Krogstad, E., Wang, C. Well-defined block copolymers for gene delivery to dendritic cells. Journal of Controlled Release 142(2): March 2010, p. 229-237.
    • 2. Ball C, Krogstad E, Chaowanachan T, Woodrow KA (2012) Drug-eluting fibers for HIV-1 inhibition and contraception. Plos One 7: e49792.
    • 3. Chaowanachan T, Krogstad E, Ball C, Woodrow KA (2013) Drug synergy of tenofovir and nanoparticle-based antiretrovirals for HIV prophylaxis. Plos One 8: e61416.
    • 4. Blakney AK, Ball C, Krogstad E, Woodrow KA (2013) Electrospun fibers for vaginal anti-HIV drug delivery. Antiviral Res 100, Supplement: S9–S16.
    • 5. Blakney AK, Krogstad E, Jiang Y, and Woodrow KA (accepted). Delivery of multipurpose prevention drug combinations from electrospun nanofibers using composite microarchitectures. Int J Nanomedicine.
  • 6. Krogstad E and Woodrow KA (in preparation). Manufacturing scale-up of electrospun poly(vinyl alcohol) fibers containing tenofovir for vaginal drug delivery.


Presentations:

  • 1. Engineering hyaluronic acid hydrogels for cardiac tissue repair, E Krogstad*, C Wang, presented at National Conference for Undergraduate Research, Salisbury, MD, 2008, oral presentation.
  • 2. Vaginal matrices: for dual prevention of HIV and unintended pregnancy, C Ball, E Krogstad*, KA Woodrow, presented at CAMI Multipurpose Prevention Technologies Symposium, Washington, D.C., 2011, invited.
  • 3. Nanomaterials for combination chemo-prophylaxis against sexual HIV transmission, E Krogstad*, T Chaowanachan, C Ball, J Phan, and KA Woodrow, presented at Conference on Retroviral and Opportunistic Infections, Seattle, WA, 2012.
  • 4. Drug-eluting nanofibers for multipurpose prevention of sexually transmitted infections and unintended pregnancy, C Ball, E Krogstad and KA Woodrow, presented at International Microbicides Conference, Sydney, NSW, AU, 2012, oral presentation.
  • 5. Evaluating drug synergy of tenofovir and nanoparticle-based antiretroviral microbicides, T Chaowanachan, E Krogstad, C Ball, J Phan and KA Woodrow, presented at International Microbicides Conference, Sydney, NSW, AU, 2012.
  • 6. Drug synergy of tenofovir and nanoparticle-based antiretroviral drugs for prophylaxis, T Chaowanachan, E Krogstad*, C Ball, and KA Woodrow, presented at Biomedical Engineering Society Annual Meeting, Atlanta, GA, 2012.
  • 7. Drug eluting fibers for STI inhibition and contraception, C Ball, E Krogstad, and KA Woodrow, presented at Biomedical Engineering Society Annual Meeting, Atlanta, GA, 2012, oral presentation.
  • 8. Manufacturing scale-up potential of electrospun poly(vinyl alcohol) fibers containing tenofovir for vaginal drug delivery, E Krogstad* and KA Woodrow, Controlled Release Society Annual Meeting and Exposition, Honolulu, HI, 2013.
  • 9. Developing nanoparticle-based combination ARVs as an effective strategy for HIV prevention, E Do, E Krogstad, D Bright, IT Suydam, and KA Woodrow, presented at Biomedical Engineering Society Annual Meeting, Seattle, WA, 2013.
  • 10. Levonorgestrel and tenofovir composite fibers for dual prevention of HIV-1 and pregnancy, AK Blakney, E Krogstad, and KA Woodrow, presented at Biomedical Engineering Society Annual Meeting, Seattle, WA, 2013.
*Presenting author


Honors and Awards:

  • National Science Foundation Graduate Fellowship (2012—current); Science Communications Fellow in Global Health, Pacific Science Center (2011-current); Summa cum laude honors, University of Minnesota (2009); Frank Louk Scholarship, University of Minnesota (2007—2009); Lynn Otten Scholarship, University of Minnesota (2007—2009); Presidential Scholarship, University of Minnesota (2005—2009).

Joseph Phan
Graduate Student, Bioengineering, 2009 - current
B.S., Chemical Engineering, Northwestern University
NSF Graduate Research Fellow
email:

More Information

Research focus:
Thermoresponsive nanoparticle systems for rapid, high sensitivity HIV detection.


Presentations:

  • 1. J.C. Phan, A. R. Tillman, K. A. Woodrow, “Hydrophobic Nanofibers with Silver Nanoparticles as a Surface Enhanced Raman Spectroscopy Substrate”. American Institute of Chemical Engineers Annual Meeting, San Francisco, CA, November 2013. Oral Presentation.
  • 2. J.C. Phan, B. J. Nehilla, R. W. Coombs, J. J. Lai, K. A. Woodrow, “A Thermoresponsive Magnetic Nanoparticle System Using an Antiviral Lectin for HIV Capture and Concentration”. Biomedical Engineering Society Annual Meeting, Seattle, WA, September 2013. Oral Presentation.
  • 3. K. L. Viola, S. Sharma, J. Lin, S. Gutiontov, J. Phan, C. Lu, P. T. Velasco, G. Shekhawat, M. P. Lambert, P. V. Prasad, R. R. Edelman, V. P. Dravid, W. L. Klein, “Possibilities for molecular diagnostic therapy in Alzheimer’s disease through Aβ oligomer-selective antibodies conjugated to theranostic nanostructures”. Society for Neuroscience Annual Meeting, Chicago, IL, November 2009. Poster Presentation.


Honors and Awards:

  • National Science Foundation Graduate Fellowship (2010—2013); Cum laude honors, Northwestern University (2009); Robert Halsey Henderson Scholarship, Northwestern University (2008); Walter Robert Yates Scholarship, Northwestern University (2007).

Renuka Ramanathan
Graduate Student, Bioengineering, 2010 - current
B.S., Biological Engineering, Massachusetts Institute of Technology
CFAR STD & AIDS Research Training Fellow
email:


Research focus:
Nanomaterials for vaginal delivery and combination HIV-1 prophylaxis.

Publications:

  • Ramanathan, R., Mahadevan, R., and Woodrow, K.A. Biophysical characterization of hydrogel-core lipid-shell nanolipogels for HIV chemoprophylaxis. In preparation.
  • 2. von Maltzahn, G., Centrone, A., Park, J.H., Ramanathan, R., Sailor, M.J., Hatton, A., and Bhatia, S.N. SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely-Multiplexed Near-Infrared Imaging and Photothermal Therapy. Advanced Materials, 21: 1-6, 2009.
  • 3. Cheng, H., Kastrup, C.J., Ramanathan, R., Siegwart, D.J., Ma, M.L., Bogatyrev, S.R., Xu, Q., Whitehead, K.A., Langer, R., Anderson, D.J. "Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery" ACS Nano, 2010 4 (2), 625-631.


Presentations:

  • 1. D. Krishnaswamy, R. Ramanathan, A. Qamar, "Collaborative Wireless Nanobots for Tumor Discovery and Drug Delivery." IEEE Molecular and Nano Communications (MONACOM), Ottawa, Canada, June 2012.
  • 2. R. Ramanathan, R. Mahadevan, M. Iadanza, T. Chaowanachan, "Biophysical characterization of hydrogel-core, lipid-shell nanolipogels for HIV chemoprophylaxis." International Microbicides Conference, Sydney, Australia, April 2012.


Honors and Awards:

  • NSF Graduate Research Fellowship (2012-current); Science Communications Fellow, Pacific Science Center (2011-2013); Center for AIDS Research Trainee Support Grant for BMES Annual Meeting (2012); Lynn Otten Merit Scholarship, University of Minnesota (2007-2009); Frank Louk Institute of Technology Merit Scholar, University of Minnesota (2007-2009); Presidential Scholarship, University of Minnesota (2005-2009)

Research Staff

Daniel Carson
Staff Scientist, 2013 - current
M.S., Bioengineering, University of Washington, 2013
B.S., Bioengineering, University of Washington, 2012
email:

Rick Edmark
Staff Scientist and Lab Manager, 2013 - current
206 221 5225 (phone)
email:

More Information

Publications:

  • Edmark RA, Genest DL. WIPO Patent WO/2002/055788. Cellulosic product having high compression recovery. Weyerhaeuser Company. Issued July 18, 2002.
  • Dopps MI, Edmark RA, Marsh DG, Graef PA. U.S. Patent 6,867,346. Absorbent composite having fibrous bands. Weyerhaeuser Company. Issued March 15, 2005.

Arielle Steger
Staff Scientist, 2013 - current
B.S., Physics, University of Washington, 2012
206 221 5225 (phone)
email:


Undergraduate Students

Hunter Bennet

Natasha Lou Comandante (mentor: J. Park)

Jessica Hung (mentor: R. Edmark)

Andrew Johnson (mentor: E. Krogstad)

William Lykins (mentor: R. Ramanathan)

Linhchi Pham (mentor: J. Park)

Ben Read (mentor: R. Ramanathan)

Alexandra Tillman (mentor: J. Phan)

Annie Wu (mentor: A. Blakney)

Lab Alumni

Reena Mahadevan, B.S./M.S. (2013)
Deep Hathi, B.S. (2013) - currently: Ph.D. Student, Biomedical Engineering, Washington University
Dr. Thanya Chaowanachan, Postdoc (2013)
Nathan Egge, B.S. (2012)
Adrienne Rothschilds, B.S. (2012) - currently: Ph.D. Student, Bioengineering, UC Berkeley
Lauren Schergen, B.S. (2011), currently: M.D. Student, New York Medical College