Principle Investigator

Kim A. Woodrow, Ph.D.
Associate Professor of Bioengineering
W.H. Foege N410D
3720 15th Avenue NE
Seattle, WA 98122-5061
206 685 6831 (phone)
email:

Research Scientists & Postdoctoral Scholars

Yonghou Jiang, D.V.M., Ph.D.
Research Scientist, 2013 - current
Research Scientist, Washington National Primate Research Center, 2013
Postdoctoral Scientist, Pathobiology, University of Washington, 2006
Vistiting Scientist, Washington National Primate Research Center, 2003
Ph.D., Veterinary Pathology, NEAU College of Veterinary Medicine, 2000
M.S., Infectious Disease, NEAU College of Veterinary Medicine, 1995
D.V.M., Veterinary Medicine, NEAU College of Veterinary Medicine, 1992
email:

Jaehyung Park, Ph.D.
Research Scientist, 2013 - current
Postdoctoral Scientist, Bioengineering, University of Washington, 2012
Ph.D., Biomedical Engineering, Georgia Institute of Technology, 2009
M.S., Chemical Engineering, Tufts University, 2004
M.S., Materials Science & Engineering, Korea Aerospace University, 1998
B.S., Materials Science & Engineering, Korea Aerospace University, 1996
email:

Graduate Students

Shijie Cao
Graduate Student, Bioengineering, 2013 - current
B.S., Pharmacy, Fudan University
email:

More Information

Research focus:
Nanoparticle-based drug delivery for prevention and treatment of HIV

Publications:

    • 1. Krogstad EA, Ramanathan R, Nhan C, Kraft JC, Blakney AK, Cao S, Ho RJY, Woodrow KA. Nanoparticle-releasing Nanofiber Composites for Enhanced In Vivo Vaginal Retention. Biomaterials. 2017;11(144):1-16.
    • 2. Jiang Y, Cao S, Bright DK, Bever AM, Blakney AK, Suydam IT, Woodrow KA. Nanoparticle-Based ARV Drug Combinations for Synergistic Inhibition of Cell-Free and Cell–Cell HIV Transmission. Molecular pharmaceutics. 2015;12(12):4363-74.
    • 3. *Gao H, *Cao S, Yang Z, Zhang S, Zhang Q, Jiang X. Preparation, Characterization and Anti-Glioma Effects of Docetaxel-Incorporated Albumin-Lipid Nanoparticles. Journal of Biomedical Nanotechnology. 2015;11(12):2137-47. (*Co-first authors)
    • 4. Gao H, Yang Z, Cao S, Xiong Y, Zhang S, Pang Z, Jiang X. Tumor cells and neovasculature dual targeting delivery for glioblastoma treatment. Biomaterials. 2014;35(7):2374-82.
    • 5. Gao H, Zhang S, Cao S, Yang Z, Pang Z, Jiang X. Angiopep-2 and Activatable Cell-Penetrating Peptide Dual-Functionalized Nanoparticles for Systemic Glioma-Targeting Delivery. Molecular Pharmaceutics. 2014;11(8):2755-63.
    • 6. Gao H, Zhang S, Yang Z, Cao S, Jiang X, Pang Z. Invitro and invivo intracellular distribution and anti-glioblastoma effects of docetaxel-loaded nanoparticles functioned with IL-13 peptide. International journal of pharmaceutics. 2014;466(1):8-17.
    • 7. Gao H, Xiong Y, Zhang S, Yang Z, Cao S, Jiang X. RGD and interleukin-13 peptide functionalized nanoparticles for enhanced glioblastoma cells and neovasculature dual targeting delivery and elevated tumor penetration. Molecular pharmaceutics. 2014;11(3):1042-52.
    • 8. Gao H, Yang Z, Zhang S, Cao S, Shen S, Pang Z, Jiang X. Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization. Scientific reports. 2013;3.
    • 9. Gao H, Yang Z, Zhang S, Cao S, Pang Z, Yang X, Jiang X. Glioma-homing peptide with a cell-penetrating effect for targeting delivery with enhanced glioma localization, penetration and suppression of glioma growth. Journal of Controlled Release. 2013;172(3):921-8.
    • 10. Gao H, Cao S, Chen C, Cao S, Yang Z, Pang Z, Xi Z, Pan S, Zhang Q, Jiang X. Incorporation of lapatinib into lipoprotein-like nanoparticles with enhanced water solubility and anti-tumor effect in breast cancer. Nanomedicine. 2013;8(9):1429-42.
    • 11. Gaoe H, Pang Z, Pan S, Cao S, Yang Z, Chen C, Jiang X. Anti-glioma effect and safety of docetaxel-loaded nanoemulsion. Archives of pharmacal research. 2012;35(2):333-41.
    • 12. Gao H, Yang Z, Cao S, Xi Z, Zhang S, Pang Z, Jiang X. Behavior and anti-glioma effect of lapatinib-incorporated lipoprotein-like nanoparticles. Nanotechnology. 2012;23(43):435101.
    • 13. *Gao H, *Qian J, Yang Z, Pang Z, Xi Z, Cao S, Wang Y, Pan S, Zhang S, Wang W. Whole-cell SELEX aptamer-functionalised poly (ethyleneglycol)-poly (ε-caprolactone) nanoparticles for enhanced targeted glioblastoma therapy. Biomaterials. 2012;33(26):6264-72.
    • 14. *Gao H, *Qian J, Cao S, Yang Z, Pang Z, Pan S, Fan L, Xi Z, Jiang X, Zhang Q. Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles. Biomaterials. 2012;33(20):5115-23.
    • 15. Huile G, Shuaiqi P, Zhi Y, Shijie C, Chen C, Xinguo J, Shun S, Zhiqing P, Yu H. A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein. Biomaterials. 2011;32(33):8669-75.

    Presentations:

    • 1. Cao S, Jiang Y, Slack SD, Yogodzinski C, Hughes SM, Levy CN, Schiffer JT, Hladik F, Jerome KR, and Woodrow KA. Lipid-polymer hybrid nanoparticles incorporating mechanistically distinct drugs for HIV cure. 2nd Bioengineering and Translational Medicine Conference. October 28-29, 2017, Minneapolis, MN. Oral presentation.
    • 2. Creighton R, Ebner M, Afunugo W, Bever A, Cao S, Jiang Y, Woodrow K, Suydam I, "A prodrug strategy to improve drug loading and determine intracellular release from nanoparticle systems" BMES 2017 Annual Meeting. October 11-14, 2017, Phoenix, AZ. Oral presentation.
    • 3. Cao S, Jiang Y, Zhang H, Kondza N, Woodrow KA, "In vivo targeting of gut-homing T cells with a dual-functional conjugated to lipid-polymer hybrid nanocarriers for HIV treatment" 7th International Conference on Bioengineering and Nanotechnology. March 19-22, 2017, Chicago, IL. Oral presentation.
    • 4. Cao S, Jiang Y, Kondza N, Woodrow KA, "Targeted co-delivery of dual-function monoclonal antibody and tipranavir to gut-homing T cells using lipid-coated PLGA nanoparticles" 43rd Annual Meeting & Exposition of the Controlled Release Society. July 17-20, 2016, Seattle, Washington. Poster presentation.
    • 5. Cao S, Jiang Y, Woodrow KA, "Lipid-coated PLGA nanoparticles conjugated with a dual-function antibody for targeted delivery of ARVs to α4β7 expressing T cells" 13th International Nanomedicine and Drug Delivery Symposium. September 16-18, 2015, Seattle, Washington. Poster presentation.
    • 6. Afunugo WE, Ebner ME, Jiang Y, Cao S, Woodrow KA, "Raltegravir prodrugs for improved nanoparticle delivery" 13th International Nanomedicine and Drug Delivery Symposium. September 16-18, 2015, Seattle, Washington. Poster presentation.
    • 7. Suydam IT, Ebner ME, Afunugo WE, Bever AM , Jiang Y, Cao S, Woodrow KA "Raltegravir Prodrugs for Improved Nanoparticle Delivery" 42nd Annual Meeting &Exposition of the Controlled Release Society. July 26-29, 2015, Edinburgh, Scotland. Oral presentation.
    • 8. Jiang Y, Cao S, Bright D, Suydam IT, Woodrow KA, "Testing of nanoparticle-based ARV drug combinations for inhibiting cell-free and cell-cell HIV transmission" 32nd Annual Symposium on Nonhuman Primate Models for AIDS. November 11-14, 2014, Portland, Oregon. Poster presentation.
    • 9. Jiang Y, Cao S, Bright D, Suydam IT, Woodrow KA, "Evaluation of nanoparticle-mediated delivery of ARV drug combinations." 31st Annual Symposium on Nonhuman Primate Models for AIDS. November 3-6, 2013, Atlanta, Georgia. Poster presentation.
    • 10. Cao S. "Nanocarriers for gut-homing T cells targeting and their applications in HIV treatment", Biomaterial Seminar, University of Washington, Seattle, WA. October 13, 2016. Oral presentation.
    • 11. Cao S. "Targeted co-delivery of dual-function monoclonal antibody and tipranavir to gut-homing T cells using lipid-coated PLGA nanoparticles", Bioengineering Department Retreat, University of Washington, WA. September 26, 2016. Lightning talk and poster presentation.
    • 12. Cao S. "Targeted Delivery of ARVs to Gut-homing T Cells using Antibody Functionalized Nanoparticles", Biomaterial Seminar, University of Washington, Seattle, WA. February 11, 2016. Oral presentation.

    • Honors and Awards:

      • Wangdao Fellow, Fudan University(2011-2013); Renmin Scholarship, Fudan University (2011); Xu Zengshou Scholarship, Funda University (2010); Qihang Fellow, Fudan University (2009-2010)

Hannah Frizzell
Graduate Student, 2014 - current
B.S., Biomedical Engineering, The University of Texas at Austin
NSF Graduate Research Fellow
email:

More Information

Research focus:
Nanotechnology for mucosal vaccine delivery.

Publications:

    • 1. Frizzell, H., Ohlsen, T. J., Woodrow, K. A. (2017) Development and optimization of protein-loaded electrospun fibers with pH-controlled release, high bioactivity, and enhanced stability. International Journal of Pharmaceutics.
    • 2. Frizzell, H., Park, J., Lou Comandante, N., Woodrow, K. A. (2016). Role of heterogeneous cell population on modulation of dendritic cell phenotype and activation of CD8 T cells for use in cell-based immunotherapies. Cellular Immunology.
    • 3. Forbes D.C., Creixell, M., Frizzell H., Peppas, N.A. (2013) Polycationic nanoparticles synthesized using ARGET ATRP for drug delivery. European Journal of Pharmaceutics and Biopharmaceutics.

    Presentations:

    • 1. Frizzell, H., Woodrow, K. A. "Optimization of Protein-Loaded Electrospun Fibers for Targeted Intestinal Delivery," Biomedical Engineering Society Annual Meeting. October 11 – 14, 2017, Phoenix, Arizona. Oral Presentation.
    • 2. Frizzell, H., Park, J., Lou Comandante, N., Woodrow, K. A. "Dendritic Cell Priming in Heterogeneous Cultures Modulates Phenotype and Function for Immunotherapy," Biomedical Engineering Society Annual Meeting. October 11 – 14, 2017, Phoenix, Arizona. Oral Presentation.
    • 3. Frizzell, H. "Making Vaccines Less of a Pain," Town Hall Seattle. April 11, 2017, Seattle, Washington. Oral Presentation.
    • 4. Frizzell, H., Woodrow, K.A. "Development of bioactive protein-loaded electrospun fibers with pH-controlled release for oral delivery," Biomaterials Seminar. October 10, 2016, Seattle, Washington. Oral Presentation.
    • 5. Frizzell, H., Forbes, D.C., Peppas, N.A. "Oral Delivery of siRNA using pH-Responsive Hydrogel Nanoparticles," Biomaterial's Day. May 31, 2013, Austin, Texas. Poster.
    • 6. Forbes, D.C., Creixell, M., Frizzell, H., Peppas, N.A. "Two-part Oral siRNA Delivers Systems for the Treatment of Colon Cancer," Cancer Prevention Research Institute of Texas. October 24, 2012, Austin, Texas. Poster.
    • 7. Frizzell, H., Forbes, D.C., Peppas, N.A. "Two-part Oral siRNA Delivery Systems: Polycationic Hydrogel Nanoparticles and Alginate Matrices," Biomaterials Day. July 27, 2012, Houston, Texas. Poster.
    • 8. Forbes, D.C., Frizzell, H., Peppas, N.A. "Comparing ARGET ATRP with Traditional Free Radical Polymerization for Versatile Polycationic Hydrogel Nanoparticles," Biomaterials Day. July 27, 2012, Houston, Texas. Poster.

    • Honors and Awards:

      • National Science Foundation Graduate Research Opportunities Worldwide Fellowship (2017); Society of Women Engineers WE15 Conference Scholarship, sponsored by Microsoft (2015); National Science Foundation Graduate Research Fellowship (2014—current); Roche/Achievement Rewards for College Scientists (ARCS) Foundation Fellowship (2014—current); Graduate with Honors, The University of Texas at Austin (2014); First Place Undergraduate Poster Presentation Competition, Biomaterials Day, Rice University (2013); Undergraduate Research Fellowship, The University of Texas at Austin (2012—2013); Russell U. Smith Family Endowed Scholarship, The University of Texas at Austin (2012—2013); Texas Exes Scholarship, The University of Texas at Austin (2009—2010).

Rachel Creighton
Graduate Student, 2016 - current
B.S., Materials Engineering, Iowa State University, 2015
NSF Graduate Research Fellow
email:

More Information

Research focus:
Antiretroviral drug synergy in nanoparticle systems; biomaterials approaches to HIV prevention and treatment.

Publications:

    • 1. Akilbekova, D., Philiph, R., Graham, A. & Bratlie, K. M. Macrophage reprogramming: Influence of latex beads with various functional groups on macrophage phenotype and phagocytic uptake in vitro. J. Biomed. Mater. Res. A 103, 262-268 (2015).
    • 2. Lindemann, W. R., Philiph, R., Chan, D.W.W., Ayers, C.T., Perez, E.M., Beckman, S.P., Strzalka, J., Chaudhary, S., Vaknin, D. Oriented polyvinylidene fluoride-trifluoroethylene (P(VDF-TrFE)) films by Langmuir-Blodgett deposition: a synchrotron X-ray diffraction study. Phys. Chem. Chem. Phys. (2015). doi:10.1039/C5CP04307G

    • Presentations:

      • 1. Non-viral gene delivery using modified poly-L-lysine, R Philiph*, KM Bratlie, Presented at the Iowa State University Honors Program Poster Symposium, Ames, IA, 2015, poster presentation.
      • 2. Macrophase separation using block copolymer blends, R Philiph*, C Oser, S Nicaise, K Berggren, Presented at the Iowa State University Symposium on Undergraduate Research and Creative Expression, Ames, IA, 2014, oral presentation.
      • 3. Macrophase separation using block copolymer blends, R Philiph*, C Oser, S Nicaise, K Berggren, Presented at the MIT Summer Research Symposium, Cambridge, MA, 2013, poster presentation.
      • *Presenting author


        Honors and Awards:

        • National Science Foundation Graduate Fellowship (2016—current); Summa cum laude honors, Iowa State University (2015); Graduate with Honors, Iowa State University (2015); Goldwater Scholar (2014—2015); Tau Beta Pi Scholar (2014—2015); Cardinal Key Honor Society (Spring 2014-Present); High Scholarship Recognition, Iowa State University (2012, 2014, 2015); Tau Beta Pi Engineering Honor Society (Fall 2013-Present); Iowa State University Honors Program (Fall 2011-Spring 2015); Alcoa Scholarship Fund, Iowa State University (Fall 2014-Spring 2015); Dr. S. Sourirajan Materials Science Scholarship, Iowa State University (Fall 2013-Spring 2015); Award for Competitive Excellence, Iowa State University (Fall 2011-Spring 2015).

Jamie Hernandez
Graduate Student, 2017 - current
B.S., Biomedical Engineering, University of Arizona, 2016
email:

More Information

Research focus:
Biomaterials for a permanent contraceptive method; biomaterials for drug delivery.

Presentations:

  • 1. J.L. Hernandez, A.K. Blakney, B.H. Katz, J.T. Jensen, K.A. Woodrow, "Optimization of drug loaded electrospun fibers to induce fibrosis of the utero-tubal junction," University of Washington Biomaterial Seminar, Seattle, Washington, November 9, 2017, oral presentation.
  • 2. J.L. Hernandez, A.K. Blakney, B.H. Katz, J.T. Jensen, K.A. Woodrow, "Optimization of drug loaded electrospun fibers to induce fibrosis of the utero-tubal junction," Biomedical Engineering Society Annual Meeting, Phoenix, Arizona, October 13, 2017, poster presentation.
  • 3. D.X. Whittier, S. Iles, C. Gilchrist, J.L. Hernandez, P. Moya, T.D. Toth, "On-Slide Reagent Concentration Feedback and Control," The University of Arizona Engineering Design Day, Tucson, Arizona, May, 2, 2016, poster presentation.
  • 4. J.L. Hernandez, C.N. MacIsaac, J.P. Vande Geest, "Device to cell seed small diameter electrospun vascular grafts," Biomedical Engineering Design Day, Tucson, Arizona, March 2, 2016, poster presentation.
  • 5. J.L. Hernandez, C.N. MacIsaac, J.P. Vande Geest, "Device to cell seed small diameter electrospun vascular grafts," Undergraduate Biology Research Program Conference, Tucson, Arizona, January 23, 2016, poster presentation.
  • 6. J.L. Hernandez, C.N. MacIsaac, J.P. Vande Geest, "Device to cell seed small diameter electrospun vascular grafts," Annual Biomedical Research Conference for Minority Students, Seattle, Washington, November 13, 2015, poster presentation.
  • 7. J.L. Hernandez, H. Kantamneni, M. Zevon, V. Ganapathy, P.V. Moghe, "Engineering Lymphatic Vasculature Models for Cancer Surveillance," Research in Science and Engineering Summer Research Symposium, Piscataway, New Jersey, July 17, 2015, oral and poster presentations.
  • 8. J.L. Hernandez, E. Tamimi, D.C. Ardila, C.N. MacIsaac, J.A. Uhlorn, J.P. Vande Geest, "Non-synthetic Electrospun Scaffold for a Tissue Engineered Vascular Graft to Model Porcine Coronary Arteries," Undergraduate Biology Research Program Conference, Tucson, Arizona, January 24, 2015, poster presentation.
  • 9. J.L. Hernandez, E. Tamimi, D.C. Ardila, C.N. MacIsaac, J.A. Uhlorn, J.P. Vande Geest, "Non-synthetic Electrospun Scaffold for a Tissue Engineered Vascular Graft to Model Porcine Coronary Arteries," Annual Biomedical Research Conference for Minority Students, San Antonio, Texas, November 13, 2014, poster presentation.
  • 10. J.L. Hernandez, E. Tamimi, D.C. Ardila, C.N. MacIsaac, J.A. Uhlorn, J.P. Vande Geest, "Non-synthetic Electrospun Scaffold for a Tissue Engineered Vascular Graft to Model Porcine Coronary Arteries," Biomedical Engineering Design Day, Tucson, Arizona, October 24, 2014, poster presentation.
  • 11. J.L. Hernandez, E. Tamimi, D.C. Ardila, C.N. MacIsaac, J.A. Uhlorn, J.P. Vande Geest, "Non-synthetic Electrospun Scaffold for a Tissue Engineered Vascular Graft to Model Porcine Coronary Arteries," Undergraduate Research Opportunities Consortium Conference, Tucson, Arizona, August 11, 2014, oral and poster presentations.

  • Honors and Awards:

    • Achievement Rewards for College Scientists (ARCS) Foundation Fellowship (2016 — current); Honorable Mention, 2017 National Science Foundation Graduate Research Fellowship Program; Raytheon Award for Best Overall Design, The University of Arizona Engineering Design Day (May 2, 2016); Maximizing Access to Research Careers (MARC) Scholar, The University of Arizona (2014 – 2015); Arizona Board of Regent's High Honors Tuition Scholarship (2012-2016).

Research Staff

Rick Edmark
Staff Scientist and Lab Manager, 2013 - current
206 685 3581 (phone)
email:

More Information

Publications:

  • Edmark RA, Genest DL. WIPO Patent WO/2002/055788. Cellulosic product having high compression recovery. Weyerhaeuser Company. Issued July 18, 2002.
  • Dopps MI, Edmark RA, Marsh DG, Graef PA. U.S. Patent 6,867,346. Absorbent composite having fibrous bands. Weyerhaeuser Company. Issued March 15, 2005.

Undergraduate Students

Alton Cao (mentor: H. Frizzell)

Jolie Phan (mentor: R. Creighton)

Sarah Slack (mentor: S. Cao)


Lab Alumni

GRADUATE STUDENTS
Anna Blakney, Ph.D. (2016) - Whitaker Scholar, Imperial College London, United Kingdom
Joseph Phan, M.S. (2016) - NanoString Technologies
Renuka Ramanathan, Ph.D. (2016) - Wilson Sonsini Goodrich & Rosati
Emily Krogstad, Ph.D. (2016) - Whitaker Scholar, Desmond Tutu HIV Foundation, South Africa
Cameron Ball, Ph.D. (2014) - Postdoctoral Scientist, Sandia National Laboratories
Reena Mahadevan, B.S./M.S. (2013)

UNDERGRADUATE CAPSTONE STUDENTS

Nina Kondza, B.S. (2017)
Christina Nhan, B.S. (2017) - Research Scientist/Engineer, Amazon Catalyst, Bioeng., UW
Tiffany Ohlsen, B.S. (2017) - Research Scientist, Just Biotherapeutics
Namratha Potharaj, B.S. (2017) - Research Scientist/Engineer, Amazon Catalyst, Bioeng., UW
Natasha Lou Comandante, B.S. (2016) - Ph.D. Candidate, Biomedical Engineering, U. Michigan
Jessica Hung, B.S. (2015) - Ph.D. Candidate, Biomedical Engineering, UVA
William Lykins, B.S. (2015) - Ph.D. Candidate, Bioengineering, UC Berkeley
Linhchi Pham, B.S. (2015) - M.D. Candidate, Tufts University
Ben Read, B.S. (2015) - Ph.D. Candidate, Health Sciences and Technology, MIT
Hunter Bennett, B.S. (2014) - M.D./Ph.D. Candidate, UC San Diego
Andrew Johnson B.S. (2014) - M.D. Candidate, Case Western Reserve University
Alexandra Tillman B.S. (2014) - Post-baccalaureate Program, NIBIB, NIH
Deep Hathi, B.S. (2013) - Ph.D. Candidate, Biomedical Engineering, Washington University
Nathan Egge, B.S. (2012) - M.D. Candidate, UT Southwestern, Dallas
Adrienne Rothschilds, B.S. (2012) - Ph.D. Candidate, Biological Engineering, MIT
Lauren Schergen, B.S. (2011), M.D. Candidate, New York Medical College

POSTDOCTORAL/RESEARCH SCIENTISTS

Dr. Hangyu Zhang, Postdoc (2017) - Assoc. Prof, Biomedeical Eng., Dalian University of Technology, China
Dr. Shih-Feng Chou, Postdoc (2016) - Assist. Prof., Mechanical Eng., University of Texas at Tyler, USA
Dr. Sharon Golan-Paz, Postdoc (2016)
Dr. Huarong Nie, Postdoc (2015)
Dr. Thanya Chaowanachan, Postdoc (2013)

Christopher Yogodzinski (2017) - Manufacturing Assoc., Twist Bioscience
Arielle Steger (2016) - Research Scientist/Engineer, Allen Institute
Ryan Stoddard (2015) - Ph.D. Student, UW Chemical Engineering
Daniel Carson (2015) - M.D. Student, UW Medicine