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Mathematical Models
Equations and discussion related to the specific mathematical models used in the Virtual Cell are summarized below.
  • Double strand break (DSB) formation and repair models
  • Cell and tissue kinetics
  • DNA fragment-size distributions
  • Genomic instability
  • Neoplastic transformation
  • Surviving fraction
  • Tumor control probability (TCP)

Tip: The widely used linear-quadratic (LQ) model is a low dose and dose rate approximation to the LPL, RMR, and TLK models (see Kinetic Models and the LQ Formalism).


  • Estimates of LQ radiosensitivity parameters
  • Biologically effective dose (BED)
  • Equivalent uniform dose (EUD)
  • Normalized Isoeffective Dose (NID)

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Last updated: 10 June, 2011
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