Welcome to the Moody Lab Web Site

Cultured brain slice neurons with intracellular recording


Coronal brain slice from a P0 mouse. Pseudocolored fluo4 calcium signal is superimposed on the camera image of the slice. This figure shows the peak of a fully propagating wave of spontaneous activity that initiated in the left ventral cortex (ventral = down) and spread throughout both cortical hemispheres. This kind of activity is described in Conhaim J, Cedarbaum ER, Barahimi M, Moore JG, Becker MI, Gleiss H, Kohl C, Moody WJ.  (2010).  Bimodal septal and cortical triggering and complex propagation patterns of spontaneous waves of activity in the developing mouse cerebral cortex.  Dev. Neuro.  70:679-692.

   Welcome to the Moody lab in the Department of Biology at the University of Washington..  The links above will take you to pages describing our research, teaching, and outreach activities.

Research

     Our research concerns the roles of spontaneons electrical activity in the development of the nervous system.  Experiments we are doing now ask how such activity is controled and what roles it plays in nervous system development.  We use patch clamp and calcium imaging methods on living slices of devloping mouse brain to study these questions.  The laboratory is small, with people at all levels (faculty from other universities on sabbatical visits, technicians, postdoctoral fellows, graduate students, and undergraduates; not all necessarily at the same time) working closely together.

Click here to see a nice movie of some of our work on highly synchronized spontaneous activity in neonatal mouse cortex.  More details about this work and the movie can be found by clicking on the "Research" link above.

Teaching

     As director of the Undergraduate Neurobiology Program at the University of Washington, I am committed to drawing undergraduates into the field of neurobiology and giving them the opportunity to share in the excitement of current research in this field.  Member of our group have also participated in the development of a educational software package, NerveWorks, designed to teach the basic concepts of cellular neurophysiology to undergraduate and graduate students through realistic experimental simulations.

Outreach

     I am also personally committed to disseminating knowledge about the nervous system to the public, and participate in several educational activities to that end.

Contact

Contact Professor Moody at profbill@u.washington.edu or use the link below.