Curriculum Vitae

William J. Moody

Birthdate:            December 26, 1950.   Massillon, Ohio, USA

Education:            B.S.   1972     Yale University           Molecular Biology and Biophysics

                              Ph.D. 1977     Stanford University     Neurobiology            

Professional History

1998-present  Director, Undergraduate Neurobiology Major, University of Washington

1997-1999     Member, Board of Directors, The Company of Biologists

1989-present  Professor, Department of Zoology, University of Washington, Seattle, WA

1987              Visiting Senior Research Fellow, University of Bristol, Bristol, U.K.

1986-1989     Associate Professor, Department of Zoology, University of Washington Seattle, WA

1983-1986     Assistant Professor, Department of Zoology, University of Washington, Seattle, WA.

1980-1983     Postdoctoral Fellow (S. Hagiwara), Department of Physiology, University of California, Los Angeles, CA.

1979-1980     Postdoctoral Fellow  (R.C. Thomas), Department of Physiology, University of Bristol, Bristol, U.K 

1977-1979     Postdoctoral Fellow (S. Hagiwara), Department of Physiology,  University of California, Los Angeles, CA.

1974-1977     Graduate Student  (Donald Kennedy), Graduate Program in Neurobiology, Stanford University, Stanford, CA

1972-1974     Graduate Student  (David A. Prince), Graduate Program in Neurobiology, Stanford University, Stanford, CA.

Publications

Couse NL, Haworth P, Moody WJ, & Cummings DJ.  (1972).  Intracellular events in canavanine-treated T4-infected Escherichia coli.  Virology  50:765-771.

Pedley TA, Fisher RS, Moody WJ, Futamachi KJ, & Prince DA.  (1974).  Extracellular potassium activity during epileptogenesis: a comparison between neocortex and hippocampus.  Trans. Am. Neurol. Assoc.  99:41-45.

Moody WJ, Futamachi KJ, & Prince DA.  (1974).  Extracellular potassium activity during epileptogenesis.  Exp. Neurol.  42:248-263.

Fisher RS, Pedley TA, Moody WJ, & Prince DA.  (1976).  The role of extracellular potassium in hippocampal epilepsy.  Arch. Neurol.  33:76-83.

Hagiwara S, Miyazaki S, Moody WJ, & Patlak J.  (1978).  Blocking effects of barium and hydrogen ions on the potassium current during anomalous rectification in the starfish egg.  J. Physiol.  279:167-185.

Moody WJ.  (1980).  Appearance of calcium action potentials in crayfish slow muscle fibres under conditions of low intracellular pH.  J. Physiol.  302:335-346.

Moody WJ. (1981).  The effect of decreased intracellular pH on the electrical properties of invertebrate muscle fibers and oocytes.  Kroc Found. Ser.  15:427-443.

Moody WJ.  (1981).  The ionic mechanism of intracellular pH regulation in crayfish neurones.  J. Physiol.  316:293-308.

Moody WJ & Hagiwara S.  (1982).  Block of inward rectification by intracellular H+ in immature oocytes of the starfish Mediaster aequalis.  J. Gen. Physiol.  79:115-130.

Moody WJ & Lansman JB.  (1983).  Developmental regulation of Ca and K currents during hormone-induced maturation of starfish oocytes.  Proc. Nat. Acad. Sci. USA  80:3096-3100.

Byerly L & Moody WJ.  (1984).  Intracellular calcium ion and calcium current in perfused neurones of the snail, Lymnaea stagnalis.  J. Physiol.  352:637-652.

Byerly L, Meech R, & Moody WJ.  (1984).  Rapidly activating hydrogen ion currents in perfused neurones of the snail, Lymnaea stagnalis.  J. Physiol.  351:199-216.

Moody WJ.  (1984).  Effects of intracellular H+ on the electrical properties of excitable cells.  Ann. Rev. Neurosci.  7:257-278.

Moody WJ & Bosma MM.  (1985).  Hormone-induced loss of surface membrane during maturation of starfish oocytes: differential effects on potassium and calcium channels.  Dev. Biol. 112:396-404.

Moody WJ. (1985).  The development of calcium and potassium currents during oogenesis in the starfish, Leptasterias hexactis.  Dev. Biol.  112:405-413.

Eusebio, E.J. & Moody, W.J. (1985).  Calcium-dependent action potentials in the prothoracic gland of Manduca sexta.  J. Exp. Biol.  126, 531-536.

Byerly L & Moody WJ.  (1986).  Membrane currents of internally perfused neurones of the snail, Lymnaea stagnalis, at low intracellular pH.  J. Physiol. 376:477-491.

Moody WJ & Byerly L  (1987).  Effects of intracellular pH and calcium activity on ion currents in internally perfused neurons of the snail Lymnaea stagnalis.  Can. J. Physiol. Pharmacol.  65:994-1000.

Block ML & Moody WJ. (1987).  Changes in sodium, calcium, and potassium currents during early embryonic development of the ascidian Boltenia villosa.  J. Physiol.  393:619-634.

Hice RE & Moody WJ. (1988).  Fertilization alters the spatial distribution and the density of voltage-dependent soldium current in the egg of the ascidian Boltenia villosa.  Dev. Biol.  127:408-420.

Simoncini L, Block ML, Moody WJ. (1988).  Lineage-specific development of calcium currents during embryogenesis.  Science  242:1572-1575.

Simoncini, L., Block, M.L. & Moody, W.J. (1988).  Lineage-specific development of calcium currents during embryogenesis.  Science 242:1572-1575.

Moody WJ & Bosma MM.  (1989).  A nonselective cation channel activated by membrane deformation in oocytes of the ascidian Boltenia villosa.  J. Memb. Biol.  107:179-188.

Simoncini L & Moody WJ.  (1990).  Changes in voltage-dependent currents and membrane area during maturation of starfish oocytes: species differences and similarities.  Dev. Biol.  138:194-201.

Block, M.L. & Moody, W.J. (1990).  A voltage-dependent chloride current linked to the cell cycle in ascidian embryos.   Science 247:1090-1092.

Bosma MM & Moody WJ.  (1990).  Macroscopic and single-channel studies of two Ca2+ channel types in oocytes of the ascidian Ciona intestinalis.  J. Memb. Biol.  114:231-243.

Moody WJ, Simoncini L, Coombs JL, Spruce AE, & Villaz M.  (1991).  Development of ion channels in early embryos.  J. Neurobiol.  22:674-684.

Simoncini L & Moody WJ.  (1991).  Dependence of Ca and K current development on RNA and protin synthesis in muscle-lineage cells of the ascidian Boltenia villosa.  J. Neurosci.  11:1413-1420.

Spruce AE & Moody WJ. (1992).  Developmental sequence of expression of voltage-dependent currents in embryonic Xenopus laevis myocytes.  Dev. Biol.  154:11-22.

Coombs JL, Villaz M, Moody WJ. (1992).  Changes in voltage-dependent ion currents during meiosis and first mitosis in eggs of an ascidian.  Dev. Biol.  153:272-282.

Nevitt GA & Moody WJ.  (1992).  An electrophysiological characterization of ciliated olfactory receptor cells of the coho salmon, Oncorhynchus kisutch.  J. Exp. Biol. 166:1-17.

Nevitt GA, Dittman AH, Quinn TP, Moody WJ. (1994).  Evidence for a peripheral olfactory memory in imprinted salmon.  Proc. Nat. Acad. Sci. USA.  91:4288-4292.

Linsdell, P. & Moody, W.J. (1994).  Na channel misexpression accelerates K channel development in embryonic Xenopus laevis skeletal muscle.  J. Physiol. 480:405-410.

Moody WJ.  (1995). Critical periods of early development created by the coordinate modulation of ion channel properties.  Perspect. Dev. Neurobiol.  2:309-315.

Linsdell, P. & Moody, W.J. (1995)   Electrical activity and calcium influx regulate ion channel development in embryonic Xenopus skeletal muscle.  J. Neurosci.  15:4507-4514.

Villaz, M., Cinniger, J.C., & Moody, W.J. (1995).  A voltage-gated chloride channel in ascidian embryos modulated by both the cell cycle clock and cell volume.  J. Physiol.  488:689-699.

Spruce, A.E. & Moody, W.J. (1995).  Modifications of current properties by expression of a foreign potassium channel gene in Xenopus embryonic cells.  J. Memb. Biol.  148:255-262.

Davis, A.K.,  Greaves, A.A., Dallman, J.E., & Moody, W.J.  (1995).  Comparison of ionic currents expressed in immature and mature muscle cells of an ascidian larva.  J. Neurosci.  15:4875-4884.

Moody, W.J. (1996).  The significance of the patterns of ion channel development in excitable cells,  in Basic Neuroscience in Invertebrates.  H. Koike, ed., pp. 431-440.  Japan Scientific Societies Press.  Tokyo.

Greaves, A.A., Davis, A.K., Dallman, J.E., & Moody, W.J. (1996).  Coordinated modulation of Ca2+ and K+ currents during ascidian muscle development.  J. Physiol. 497:39-52.

Moody, W.J.  (1998).  The control of spontaneous activity during development.  J. Neurobiol.  37:97-109.

Moody WJ.  (1998).  The development of voltage-gated ion channels and its relation to activity-dependent developmental events.  Curr. Top. Dev. Biol.  39:159-185.

Jacquin, TD, Yool, A, Benoit, E, Spitzer, NC, & Moody, WJ.  (1998).  Petites cellules excitables deviendront grandes: le rythme pour la raison.  Medicine Sciences  14: 63-71.

Dallman, J.E., Davis, A.K., & Moody, W.J. (1998).  Spontaneous activity regulates Ca-dependent K current expression in developing ascidian muscle.  J. Physiol.  511:683-693.  (See associated “Perspectives” article by Ribera: pg. 645.)

Currie, D.A. & Moody, W.J.  (1999).  Time course of ion channel development in Xenopus muscle induced in vitro by activin.  Dev. Biol.  209: 40-51.

Dallman, J.E., Dorman, J., & Moody, W.J.  (2000).  Action potential waveform voltage clamp reveals the significance of the patterns of ion channel development in ascidian muscle.  J. Physiol.  524:375-386.

Huey, R.B. & Moody, W.J.  (2002).  Neuroscienc and evolution. Snake sodium channels resist TTX arrest.  Science 297: 1289-1290.

Bahrey, H.P. & Moody, W.J.  (2003).  Voltage-gated currents, dye and electrical coupling in the embryonic mouse neocortex.  Cerebral Cortex  13:239-51.

Picken-Bahrey, H.P., Albrieux, M., & Moody, W.J.  (2003).  Early Development of Voltage-Gated Ion Currents and Firing Properties in Neurons of the Mouse Cerebral Cortex. J. Neurophysiol.  89:1761-73

Albrieux, M., Platel, J-C., Dupuis, A., Villaz, M., & Moody, W.J.  (2004).  Early expression of sodium channel transcripts and sodium current in Cajal-Retzius cells in the preplate of the embryonic mouse neocortex.  J. Neurosci.  24:1719-25

Corlew, R., Bosma, M.M., & Moody, W.J.  (2004).  Spontaneous, synchronous electrical activity in neonatal mouse cortical neurons.  J. Physiol. 560, 377-390.

Moody WJ  (2004).  Subtype-specific mechanisms for regulating K+ channel density during development.  Focus on "The carboxyl tail region of the Kv2.2 subunit mediates novel development of channel density."  J. Neurophysiol. 92:3169-3170.

Moody, W.J. & Bosma, M.M. (2005).  Ion Channel Development, Spontaneous Activity, and Activity-dependent Development in Nerve and Muscle Cells.  Invited review. Physiol. Rev. 85:883-941.

Currie, D.A., de Vente, J., & Moody, W.J. (2006).  Developmental appearance of cyclic guanosine monophosphate (cGMP) production and nitric oxide responsiveness in embryonic mouse cortex and striatum.  Developmental Dynamics  235:1668-77.

McCabe, A.K., Chisholm, S.L., Picken-Bahrey HL, & Moody, W.J.  (2006).  The self-regulating nature of spontaneous synchronized activity in developing mouse cortical neurones.  J. Physiol.  577:155-167.

McCabe, AK, Easton, CR, Lischalk, J, & Moody, WJ (2007).  Roles of glutamate and GABA receptors in setting the developmental timing of spontaneous synchronized activity in the developing mouse cortex.  Dev. Neurobiol. 67:1574-1588.

Lischalk JW, Easton CR, Moody WJ. (2009).  Bilaterally propagating waves of spontaneous activity arising from discrete pacemakers in the neonatal mouse cerebral cortex.  Dev. Neurobiol. 69, 407-14.

Currie DA, Corlew R, deVente J, Moody WJ.  (2009).  Elevated glutamate and NMDA disrupt production of the second messenger cyclic GMP in the early postnatal mouse cortex.  Dev. Neurobiol.  69:255-266.

Conhaim J, Cedarbaum ER, Barahimi M, Moore JG, Becker MI, Gleiss H, Kohl C, Moody WJ.  (2010).  Bimodal septal and cortical triggering and complex propagation patterns of spontaneous waves of activity in the developing mouse cerebral cortex.  Dev. Neuro.  70:679-692.