UW
VMBHRC

Hume Lab

Virginia Merrill Bloedel Hearing Research Center

Department of Otolaryngology-Head and Neck Surgery

 

Publications

Original Articles:
 Hume, C. R., Accolla, R. S., and Lee, J. S. (1987). Defective HLA class II expression in a regulatory mutant is partially complemented by activated ras oncogenes. Proc Natl Acad Sci U S A 84, 8603-8607.

Hume, C. R., Nocka, K. H., Sorrentino, V., Lee, J. S., and Fleissner, E. (1988). Constitutive c-myc expression enhances the response of murine mast cells to IL-3, but does not eliminate their requirement for growth factors. Oncogene 2, 223-226.

Sorrentino, V., McKinney, M. D., Drozdoff, V., Hume, C. R., and Fleissner, E. (1988). Spontaneous or carcinogen-mediated amplification of a mutated ras gene promotes neoplastic transformation. Oncogene Res 2, 189-195.

Hume, C. R., and Lee, J. S. (1989). Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors. Hum Immunol 26, 288-309.

Hume, C. R., Shookster, L. A., Collins, N., O'Reilly, R., and Lee, J. S. (1989). Bare lymphocyte syndrome: altered HLA class II expression in B cell lines derived from two patients. Hum Immunol 25, 1-11.

Hume, C. R., and Lee, J. S. (1990). Functional analysis of cis-linked regulatory sequences in the HLA DRA promoter by transcription in vitro. Tissue Antigens 36, 108-115.

Mattioni, T., Hume, C. R., Konigorski, S., Hayes, P., Osterweil, Z., and Lee, J. S. (1992). A cDNA clone for a novel nuclear protein with DNA binding activity. Chromosoma 101, 618-624.

Hume, C. R., and Dodd, J. (1993). Cwnt-8C: a novel Wnt gene with a potential role in primitive streak formation and hindbrain organization. Development 119, 1147-1160.

Bannish, G., Hume, C., and Lee, J. S. (1996). Coordinate regulation of HLA class II genes: a novel DNA binding complex. Mol Immunol 33, 407-415.

Shah, S., Skromne, I., Hume, C., Kessler, D., Lee, K., Stern, C., and Dodd, J. (1997). Misexpression of chick Vg1 in the marginal zone induces primitive streak formation. Development 124, 5127-5138.

Popperl, H., Schmidt, C., Wilson, V., Hume, C. R., Dodd, J., Krumlauf, R., and Beddington, R. S. (1997). Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm. Development 124, 2997-3005.

Hume, C. R., Kierkegaard, M., Oesterle, E. C. (2003). ErbB Expression: The Mouse Inner Ear and Maturation of the Mitogenic Response to Heregulin. J Assoc Res Otolaryngol. 4, 422-443.

Lee, C. C., Shen. I., Hume, C., Gao, G. (2005). A Feasibility Study of PZT Thin-Film Microactuators for Hybrid Cochlear Implants. Conf Proc IEEE Eng Med Biol Soc 2(1), 1929-1932.

Bermingham-McDonogh, O, Oesterle, E.C., Stone, J.S., Hume, C. R., Huynh, H., Hayashi, T. (2006) The expression of Prox1 during mouse cochlear development. J. Comp. Neurol. 10;496(2), 172-86.

Hume, C. R., Bratt, D. L, Oesterle, E. C. (2007). Expression of LHX3 and SOX2 during mouse inner ear development. Gene Expression Patterns, Mechanisms of Development. In press. [Epub 2007 May 26].

Oesterle, E. C., Campbell, S., Taylor, R. R., Forge, A., Hume, C. R. Sox2 and Jagged1 Expression in Normal and Drug-Damaged Adult Mouse Inner Ear. Accepted: J Assoc Res Otolaryngol, June 2007.

Reviews:
Lee, J. S., Cohen, E. B., Hume, C. R., and Sartoris, S. (1986). Organization, polymorphism, and regulation of class II genes of the major histocompatibility complex. Year Immunol 2, 205-221.

Hume, C. R., and Lee, J. S. (1990). Genetics of HLA class II regulation. Immunol Res 9, 93-102.

Kuhel, W. I., Hume, C. R., and Selesnick, S. H. (1996). Cancer of the external auditory canal and temporal bone. Otolaryngol Clin North Am 29, 827-852.

Oesterle, E. C., and Hume, C. R. (1999). Growth factor regulation of the cell cycle in developing and mature inner ear sensory epithelia. J Neurocytol 28, 877-887.

Manuscripts Submitted:
 Lee, C. C., Hume, C. R., Cao, G. Z., Shen, I. Y. Temporary Packaging of PZT Thin-Film Microactuators. Under review: Integrated Ferroelectrics, 2007.

Latest Abstracts:
 Lee, C.C., Guo, Q., Hume, C. R., Cao, G. Z., Shen, I. Y. (2007) Electrode Optimization of PZT thin-film microactuators for hybrid cochlear implants. 2007 Conference on Implantable Auditory Prostheses. Granlibakken Conference Center, Tahoe City, CA.

Oesterle, E. C., Campbell, S., Taylor, R., Forge, A., Hume, C. R. Sox2 and Jagged1 Expression in Adult Mouse Inner Ear Sensory Epithelia. (2007) Association for Research in Otolaryngology, 30th Midwinter Conference, Denver CO.

Hume, C. R., Xiao, M., Lin, H.P., Hsia, J. C., Iguchi, F. (2007) In vitro and in vivo targets of viral infection in the mouse inner ear. Association for Research in Otolaryngology, 30th Midwinter Conference, Denver, CO.

Hume, C. R. (2005) Transcriptional Regulation of Hair Cell Development. American Academy of Otolaryngology-Head and Neck Surgery, Annual Meeting, Los Angeles CA .

Lee, C.C., Hume, C. R., Cao, G. Z., Shen, I. Y. (2005) Development of PZT thin-film microactuators for hybrid cochlear implants. 2005 Conference on Implantable Auditory Prostheses. Asilomar Conference Center, Pacific Grove, CA.

Lee, C.C., Hume, C. R., Cao, G. Z., Shen, I. Y. (2005) A Feasibility Study of PZT Thin-Film Microactuators for Hybrid Cochlear Implants. 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Shanghai, China. September 1-4, 2005.

Hume, C. R. (2005) Transcriptional Regulation of Hair Cell Development. American Academy of Otolaryngology-Head and Neck Surgery, Annual Meeting, Los Angeles CA.

Bermingham-McDonogh, O., Stone, J. S., Hume. C. R., Oesterle, E. C. (2005) Developmental Expression of the Homeobox Transcription Factor Prox1 in the Murine Organ of Corti. Association for Research in Otolaryngology, 28th Midwinter Conference.

Hume, C. R. and E. C. Oesterle. Expression of EGF receptors in neonatal and adult mouse inner ear. (2001). Association for Research in Otolaryngology, 24th Midwinter Conference. St Petersberg, FL.

Hume, C. R. and E. C. Oesterle. Induction of hair cell phenotype in neonatal mouse inner ear by ectopic transcription factor expression. (2001). Association for Research in Otolaryngology, 24th Midwinter Conference. St Petersberg, FL.

Invention Disclosures:
Active Incudo-stapedial Prosthetic Joints. UWTech Transfer Reference Number 7092D. August 23, 2004.

Hybrid Cochlear Implants. UWTech Transfer Reference Number 4146DL. January 18, 2005.

Other Invited Lectures:
2001 Sixth Annual Asian Course in Temporal Bone/ Ear Surgery. Otolaryngology Institute of Thailand, Bangkok, Thailand. Clinical and Didactic Instructor, Temporal Bone Imaging. November 2001.

2005 “Molecular Therapeutics of Hearing Loss”. Washington Society of Audiology, Annual Meeting. Seattle, WA. June 3, 2005.

2005 “Steps Towards Molecular Therapeutics of Hearing Loss.” UW Dept. of Otolaryngology-Head and Neck Surgery, Alumni Day. Seattle, WA June 10, 2005.

2006 “New tools for the treatment of hearing loss”. Hearing Loss Association of America (SHHH). Hearthstone Chapter, Seattle, WA. February 14, 2006.

2006 “Hearing Loss: Molecular Therapy”. UWTV Inside Access. Production date March 3, 2006. http://www.uwtv.org/programs/displayevent.aspx?rID=4126

2006 "Inner ear development: tools for the treatment of hearing loss". Graduate Program in Neurobiology & Behavior, University of Washington. Seattle, WA. May 22, 2006.

2006 “Molecular Therapeutics for Hearing Loss”. Institute for Stem Cell and Regenerative Medicine, Conference for Choongwae Pharma. Seattle, WA. July 26, 2006.


.