We used cryoEM to determine the first structure of a coronavirus spike glycoprotein at near-atomic resolution.
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CryoEM as a tool for drug design
The cryoEM reconstruction of the proteasome at 2.8 Å resolution enables identifying amino-acid side chains rotamers and resolving ordered water molecules.
Near-atomic resolution cryo-electron microscopy using direct detectors
Recording movies of ice-embedded samples using direct detectors allows to reduce blurring due to beam-induced movement.
Viral infection
Bacterial viruses are efficient nanomachines possessing a tail appendage used to recognize the host and ensure genome delivery via perforation of the host cell wall.
The secrets of life in boiling acids
Image
Near-atomic resolution structure of Sulfolobus Turreted Icosahedral Virus determined by single-particle cryo-electron microscopy
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