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Main text

Transgenic Mouse Resource for Interferon-stimulated PKR Protein Kinase Pathway Genes

Mouse line information
Strain C57BL/6
Transgenic type huPKR, CMV PKR
ES Cell Line WD44 (C57BL/6)
Backcross Generation 8
Strain Development HuPKR mice were developed following procedures in the manual Current Protocols in Toxicology: Transgenic animals in toxicology(Ladiges and Ware 1998)
Phenotype HuPKR is expressed and active in various tissues, and is associated with a small-body phenotype.
Applications A wide variety of research applications are available for these mice including, but not limited to:
Protein Synthesis regulation in virally infected cells.
Resistance against stress-induced apoptosis.
Lifespan extending.
Flow cytometry and immunological response to viral infection.

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