Ladiges lab
PKR Home
Available
lines Comparative Mouse Genomics Center
Transgenic
Resources Program Nathan
Shock Center Center
for Ecogenetics and Environmental Health
Mouse Lines
We are generating transgenic mice overexpressing PKR regulatory pathway genes, using a general tissue promoter, and wild type as well as dominant negative gene mutations. The specific pathway genes consist of P58IPK and PKR. We have generated a PKRCMV line.
Embryonic Stem Cell Lines
We are developing genetically altered mouse ES cell lines overexpressing
the PKR regulatory pathway genes PKR, and P58IPK.
Mouse Phenotyping
We are characterizing and
phenotyping unique lines of PKR pathway transgenic mice for specific diseases and biological conditions.
We anticipate these transgenic mouse models will have
far reaching implications for biomedical research as well as
for spontaneously occurring virus diseases of laboratory
rodents.
These mice will be great models for investigating the translational mechanics of the following diseases and subjects:
- Neuromuscular Diseases (e.g. Hutington's, Alzheimer's)
- Immunity
- Cancer
- Environmental Stress
- DNA Damage and Repair
- Viral infection (Influenza, AIDS, Hepatitis C)
- Diabetes
- Cardiovascular Disease
- Muscle Development and Aging
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