The protein products of genes do not act in isolation, but form networks of multi-protein complexes, tiny molecular machines that function only when assembled correctly and working in concert. My lab develops novel experimental and computational methods to analyze the behavior of these multi-protein complexes. We use these techniques, along with molecular and genetic approaches, to model dynamic protein interaction networks as they process information; to investigate how these networks are disrupted in complex diseases such as autism; and to manipulate these networks to control cellular behavior.
Associate Professor, Dept. of Pediatrics, UW School of Medicine
-and- Graduate Program in Neuroscience, University of Washington
Principal Investigator, Center for Integrative Brain Research, Seattle Children’s Research Institute
Google Scholar Profile. . . . . . . . .SCRI Homepage . . . . . . . . . UW Neuroscience Profile
email: seps@uw.edu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Dr. Smith’s CV