This work reported cilia-associated oxysterols can activate Hedgehog signaling through Smoothened and inhibition of the formation of such oxysterols can impede Hedgehog pathway activation. This is a multi-institutional collaboration led by David Raleigh and Jeremy Reiter at UCSF. Good job by Kelly on the oxysterol analysis in this work! Check out the paper here and the Cover Art of the issue illustrating findings in this paper.