We identified ACE2 as the SARS-CoV-2 receptor and determined the viral spike glycoprotein cryoEM structure
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Membrane fusion activation
SARS-CoV and MERS-CoV human neutralizing antibodies revealed an unprecedented mechanism of receptor-functional mimicry.
Germline antibody binding to HIV envelope
We showed how germline precursors of VRC01-class broadly neutralizing antibodies could bind to HIV envelope by tailoring the protein and glycan moieties.
Epstein-Barr virus inhibition
We determined the first structure of a human antibody in complex with the Epstein-Barr virus glycoproteins revealing an unprecedented mechanism of neutralization of dual-tropic infection.
Deltacoronavirus spike structure
Our work provides a structural framework to understand how enterotropic coronaviruses evolved to fine-tune fusion activation in the protease-rich environment of the small intestine.
Antibody-mediated integrin inhibition
We characterized the molecular mechanism of human αVβ3 integrin inhibition by the candidate therapeutic antibody LM609.
Coronavirus spike postfusion structure
First cryoEM structure of a viral fusion protein in the postfusion conformation providing new insights about coronavirus infection.
Visualizing a CNG channel
We characterized a cyclic nucleotide-gated ion channel using cryoEM to yield new insights about the mode of action of this medically important channel family.
Francisella type VI secretion system
We identified and characterized type VI secretion system effectors promoting Francisella growth in macrophages.
Epitope masking and glycan shield
Our atomic resolution structure of a human coronavirus spike protein highlights strategies used by these viruses to evade the immune system.