Welcome to the SEPS lab

Seattle Children’s Research Institute

Department of Pediatrics

University of Washington


The SEPS lab investigates how intracellular signal transduction networks convey information, and how these information-processing networks break down in diseases such as autism.

Lab News

6/13/18 Anastasiia Stratiievska uploads a paper to BioRXiv about the regulation of TRP channels by PI3Kinase, which includes data generated by Dr. Lautz. Congratulations to all involved!

5/27/2018 Dr. Lautz publishes a paper describing our multiplex co-immunoprecipitation platform applied to synaptic signaling in neurons. Read it HERE.

12/1/2017 The SEPS Lab begins its new R01 funding from the National Institute of Mental Health!

8/9/2016 Dr. Smith’s Grand Rounds talk at Seattle Children’s Hospital is available HERE

8/8/2016 Dr. Smith is named a 2016 NARSAD Young Investigator by the Brain and Behavior Research Foundation

8/2/2016 The first paper describing our multiplex co-immunoprecipitation technique has been published in Science Signaling. Read it HERE.

In the brain, information is processed at synapses, the points of connection between neurons that are responsible for learning and memory.  This neuron has been stained with PSD95 (red) and Ube3a (green). Both proteins occur at synapses, points of intense staining distributed along the dendrite.