• Selected publications in Clinical Informatics, November 2012 - October 2013
  
• Selected publications in Bioinformatics, November 2011 - October 2012
• Editor's Choice publications
• Top Ten Events of the Year
  
• Methods used to identify candidate literature and events discussed at this session
• PowerPoint slides used at this session in PPT and PDF format are availalble here..
  
• Links to other Year in Review sessions.

• Computerized Clinical Decision Support
• Telemedicine
• Health Applications of Mobile Electronics
  
• The Practice of Clinical Informatics
• Unintended Effects of Clinical Systems

For Providers

1. Kempe A, et. al, Population-based versus practice-based recall for childhood immunizations: a randomized controlled comparative effectiveness trial. Am J Public Health. 2013 Jun;103(6):1116-23.
   
2. Chambers LW, et. al, Impact of the Ottawa Influenza Decision Aid on healthcare personnel's influenza immunization decision: a randomized trial. J Hosp Infect. 2012 Nov;82(3):194-202.
   
3. Forrest CB, et. al, Improving adherence to otitis media guidelines with clinical decision support and physician feedback. Pediatrics. 2013 Apr;131(4):e1071-81.
   
4. Robbins GK, et. al, Efficacy of a clinical decision-support system in an HIV practice: a randomized trial. Ann Intern Med. 2012 Dec 4;157(11):757-66.
   
5. Were MC, et. al, Computer-generated reminders and quality of pediatric HIV care in a resource-limited setting. Pediatrics. 2013 Mar;131(3):e789-96.
   

Medication management

1. Piazza G, et. al, Randomized trial of physician alerts for thromboprophylaxis after discharge. Am J Med. 2013 May;126(5):435-42.

1. Rindal DB, et. al, Computer-assisted guidance for dental office tobacco-cessation counseling: a randomized controlled trial. Am J Prev Med. 2013 Mar;44(3):260-4.
   

1. Chen YY, et. al, Using a criteria-based reminder to reduce use of indwelling urinary catheters and decrease urinary tract infections. Am J Crit Care. 2013 Mar;22(2):105-14.
   
2. Dalal AK, et.. al. Impact of an automated email notification system for results of tests pending at discharge: a cluster-randomized controlled trial. J Am Med Inform Assoc. 2013 Oct 23.
   
3. Szucs-Farkas Z, et. al, Comparison of dual-energy subtraction and electronic bone suppression combined with computer-aided detection on chest radiographs: effect on human observers' performance in nodule detection. AJR Am J Roentgenol. 2013 May;200(5):1006-13.
   
4. Gimbel RW, et. al, Radiation exposure and cost influence physician medical image decision making: a randomized controlled trial. Med Care. 2013 Jul;51(7):628-32.
5. Freundlich RE, et. al, A randomized trial of automated electronic alerts demonstrating improved reimbursable anesthesia time documentation. J Clin Anesth. 2013 Mar;25(2):110-4.
   

1. Fiks AG, et. al, Effectiveness of decision support for families, clinicians, or both on HPV vaccine receipt. Pediatrics. 2013 Jun;131(6):1114-24.

1. van Tol-Geerdink JJ, et. al, Choice between prostatectomy and radiotherapy when men are eligible for both: a randomized controlled trial of usual care vs decision aid. BJU Int. 2013 Apr;111(4):564-73..
   
2. Green BB, et. al, An automated intervention with stepped increases in support to increase uptake of colorectal cancer screening: a randomized trial. Ann Intern Med. 2013 Mar 5;158(5 Pt 1):301-11.
   
3. Schroy PC 3rd, et. al, Aid-assisted decision making and colorectal cancer screening: a randomized controlled trial. Am J Prev Med. 2012 Dec;43(6):573-83.
   

1. Arndt J, et. al, The interactive effect of mortality reminders and tobacco craving on smoking topography. Health Psychol. 2013 May;32(5):525-32.
   

1. Duke JD, et. al, Adherence to drug-drug interaction alerts in high-risk patients: a trial of context-enhanced alerting. J Am Med Inform Assoc. 2013 May 1;20(3):494-8.
2. Beeckman D, et. al, A multi-faceted tailored strategy to implement an electronic clinical decision support system for pressure ulcer prevention in nursing homes: a two-armed randomized controlled trial. Int J Nurs Stud. 2013 Apr;50(4):475-86. .
   
3. Nieuwlaat R, et. al, Randomised comparison of a simple warfarin dosing algorithm versus a computerised anticoagulation management system for control of warfarin maintenance therapy. Thromb Haemost. 2012 Dec;108(6):1228-35.
   

1. Zhou L, et. al, Structured representation for core elements of common clinical decision support interventions to facilitate knowledge sharing. Stud Health Technol Inform. 2013;192:195-9.*
2. Kawamoto K, et. al, Key principles for a national clinical decision support knowledge sharing framework: synthesis of insights from leading subject matter experts. J Am Med Inform Assoc. 2013 Jan 1;20(1):199-207.*
3. Dixon BE, et. al, A pilot study of distributed knowledge management and clinical decision support in the cloud. Artif Intell Med. 2013 Sep;59(1):45-53.*

1. Dixon BJ, et. al, Surgeons blinded by enhanced navigation: the effect of augmented reality on attention. Surg Endosc. 2013 Feb;27(2):454-61.
   
2. Singh H, et. al, Information overload and missed test results in electronic health record-based settings. JAMA Intern Med. 2013 Apr 22;173(8):702-4.
   
3. Phansalkar S, et. al, Drug-drug interactions that should be non-interruptive in order to reduce alert fatigue in electronic health records. J Am Med Inform Assoc. 2013 May 1;20(3):489-93.*
4. Novak LL, et. al, Mediation of adoption and use: a key strategy for mitigating unintended consequences of health IT implementation. J Am Med Inform Assoc. 2012 Nov-Dec;19(6):1043-9.
   

Telemedicine

Cardiovascular diseases: hypertension

1. Margolis KL, et. al, Effect of home blood pressure telemonitoring and pharmacist management on blood pressure control: a cluster randomized clinical trial. JAMA. 2013 Jul 3;310(1):46-56.
   
2. McKinstry B, et. al, Telemonitoring based service redesign for the management of uncontrolled hypertension: multicentre randomised controlled trial. BMJ. 2013 May 24;346:f3030.
   
3. Bove AA, et. al, Managing hypertension in urban underserved subjects using telemedicine--a clinical trial. Am Heart J. 2013 Apr;165(4):615-21.
   
4. Magid DJ, et. al, A pharmacist-led, American Heart Association Heart360 Web-enabled home blood pressure monitoring program. Circ Cardiovasc Qual Outcomes. 2013 Mar 1;6(2):157-63.
   
5. Jackson GL, et. al, Racial differences in the effect of a telephone-delivered hypertension disease management program. J Gen Intern Med. 2012 Dec;27(12):1682-9.

1. Reid RD, et. al, Randomized trial of an internet-based computer-tailored expert system for physical activity in patients with heart disease. Eur J Prev Cardiol. 2012 Dec;19(6):1357-64.
   

1. Tang PC, et. al, Online disease management of diabetes: engaging and motivating patients online with enhanced resources-diabetes (EMPOWER-D), a randomized controlled trial. J Am Med Inform Assoc. 2013 May 1;20(3):526-34.
   
2. Trief PM, et. al, Adherence to diabetes self care for white, African-American and Hispanic American telemedicine participants: 5 year results from the IDEATel project. Ethn Health. 2013;18(1):83-96.
   
3. Stone RA, et. al, The Diabetes Telemonitoring Study Extension: an exploratory randomized comparison of alternative interventions to maintain glycemic control after withdrawal of diabetes home telemonitoring. J Am Med Inform Assoc. 2012 Nov-Dec;19(6):973-9.
   

1. Lovejoy TI. Telephone-delivered motivational interviewing targeting sexual risk behavior reduces depression, anxiety, and stress in HIV-positive older adults. Ann Behav Med. 2012 Dec;44(3):416-21.
   

1. Derose SF, et. al, Automated outreach to increase primary adherence to cholesterol-lowering medications. JAMA Intern Med. 2013 Jan 14;173(1):38-43.
   

1. Glozier N, et. al, Internet-delivered cognitive behavioural therapy for adults with mild to moderate depression and high cardiovascular disease risks: a randomised attention-controlled trial. PLoS One. 2013;8(3):e59139. 
   
2. Fortney JC, et. al, Practice-based versus telemedicine-based collaborative care for depression in rural federally qualified health centers: a pragmatic randomized comparative effectiveness trial. Am J Psychiatry. 2013 Apr 1;170(4):414-25.
   
3. Moreno FA, et. al, Use of standard Webcam and Internet equipment for telepsychiatry treatment of depression among underserved Hispanics. Psychiatr Serv. 2012 Dec;63(12):1213-7.
4. Hunkeler EM, et. al, A web-delivered care management and patient self-management program for recurrent depression: a randomized trial. Psychiatr Serv. 2012 Nov;63(11):1063-71.
   
5. Moritz S, et. al, The more it is needed, the less it is wanted: attitudes toward face-to-face intervention among depressed patients undergoing online treatment. Depress Anxiety. 2013 Feb;30(2):157-67.
   
6. Lintvedt OK, et. al, Evaluating the effectiveness and efficacy of unguided internet-based self-help intervention for the prevention of depression: a randomized controlled trial. Clin Psychol Psychother. 2013 Jan-Feb;20(1):10-27.

1. Whittemore R, et. al, An internet obesity prevention program for adolescents. J Adolesc Health. 2013 Apr;52(4):439-47.
   
2. Stanczyk NE, et. al, Influence of delivery strategy on message-processing mechanisms and future adherence to a Dutch computer-tailored smoking cessation intervention. J Med Internet Res. 2013 Feb 6;15(2):e28.
   
3. Rooke S, et. al, Effectiveness of a self-guided web-based cannabis treatment program: randomized controlled trial. J Med Internet Res. 2013 Feb 15;15(2):e26.
   
4. Schneider F, et. al, Periodic email prompts to re-use an internet-delivered computer-tailored lifestyle program: influence of prompt content and timing. J Med Internet Res. 2013 Jan 31;15(1):e23.
   

1. Buhrman M, et. al, Guided Internet-delivered cognitive behavioural therapy for chronic pain patients who have residual symptoms after rehabilitation treatment: randomized controlled trial. Eur J Pain. 2013 May;17(5):753-65.
   
2. Deen TL, et. al, Patient acceptance of and initiation and engagement in telepsychotherapy in primary care. Psychiatr Serv. 2013 Apr 1;64(4):380-4.
   
3. Carter FA, et. al, Suitability and acceptability of computerised cognitive behaviour therapy for anxiety disorders in secondary care. Aust N Z J Psychiatry. 2013 Feb;47(2):142-52.
   
4. Powell J, et. al, Effectiveness of a web-based cognitive-behavioral tool to improve mental well-being in the general population: randomized controlled trial. J Med Internet Res. 2012 Dec 31;15(1):e2.
   
5. Irvine AB, et. al, Web-based intervention to promote physical activity by sedentary older adults: randomized controlled trial. J Med Internet Res. 2013 Feb 5;15(2):e19.

1. Piqueras M, et. al, Effectiveness of an interactive virtual telerehabilitation system in patients after total knee arthoplasty: a randomized controlled trial. J Rehabil Med. 2013 Apr;45(4):392-6.
   
2. Pedone C, et. al, Efficacy of multiparametric telemonitoring on respiratory outcomes in elderly people with COPD: a randomized controlled trial. BMC Health Serv Res. 2013 Mar 6;13:82.
   
3. Ali J, et. al, Telemedicine as a potential medium for teaching the advanced trauma life support (ATLS) course. J Surg Educ. 2013 Mar-Apr;70(2):258-64.
   
4. Schwarz EB, et. al, Computer-assisted provision of hormonal contraception in acute care settings. Contraception. 2013 Feb;87(2):242-50. doi: 10.1016/j.contraception.2012.07.003.
   
5. Salisbury C, et. al, A pragmatic randomised controlled trial of the effectiveness and cost-effectiveness of 'PhysioDirect' telephone assessment and advice services for physiotherapy. Health Technol Assess. 2013 Jan;17(2):1-157, v-vi.
   

1. Wagner G, et. al, Internet-delivered cognitive-behavioural therapy v. conventional guided self-help for bulimia nervosa: long-term evaluation of a randomised controlled trial. Br J Psychiatry. 2013 Feb;202:135-41.
   
2. Schopf T, et. al, Impact of interactive web-based education with mobile and email-based support of general practitioners on treatment and referral patterns of patients with atopic dermatitis: randomized controlled trial. J Med Internet Res. 2012 Dec 5;14(6):e171.
   
3. Cartwright M, et. al, Effect of telehealth on quality of life and psychological outcomes over 12 months (Whole Systems Demonstrator telehealth questionnaire study): nested study of patient reported outcomes in a pragmatic, cluster randomised controlled trial BMJ. 2013 Feb 26;346:f653.

For acquiring data from study participants

1. Kristjánsdóttir ÓB, et. al, A smartphone-based intervention with diaries and therapist-feedback to reduce catastrophizing and increase functioning in women with chronic widespread pain: randomized controlled trial. J Med Internet Res. 2013 Jan 7;15(1):e5.
   

1. Junod Perron N, et. al, Text-messaging versus telephone reminders to reduce missed appointments in an academic primary care clinic: a randomized controlled trial. BMC Health Serv Res. 2013 Apr 4;13:125.
   
2. Lin H, et. al, Effectiveness of a short message reminder in increasing compliance with pediatric cataract treatment: a randomized trial. Ophthalmology. 2012 Dec;119(12):2463-70.
   
3. Evans WD, et. al, Pilot evaluation of the text4baby mobile health program. BMC Public Health. 2012 Nov 26;12:1031.
   

1. Mbuagbaw L, et. al, The Cameroon Mobile Phone SMS (CAMPS) trial: a randomized trial of text messaging versus usual care for adherence to antiretroviral therapy. PLoS One. 2012;7(12):e46909.
   

1. Smith SW, et. al, Healthcare information technology's relativity problems: a typology of how patients' physical reality, clinicians' mental models, and healthcare information technology differ. J Am Med Inform Assoc. 2013 Jun 26.
   
2. White RW, et. al, Web-scale pharmacovigilance: listening to signals from the crowd. J Am Med Inform Assoc. 2013 May 1;20(3):404-8.*
3. Lauer MS, et. al, The randomized registry trial--the next disruptive technology in clinical research? N Engl J Med. 2013 Oct 24;369(17):1579-81.*
4. Boland MR, et. al, Discovering medical conditions associated with periodontitis using linked electronic health records. J Clin Periodontol. 2013 May;40(5):474-82.
5. Morgan AJ, et. al, Internet-based recruitment to a depression prevention intervention: lessons from the Mood Memos study. J Med Internet Res. 2013 Feb 12;15(2):e31.

1. Loughran SP, et. al, No increased sensitivity in brain activity of adolescents exposed to mobile phone-like emissions. Clin Neurophysiol. 2013 Jul;124(7):1303-8.
   
2. Kim H, et. al, Kinematic data analysis for post-stroke patients following bilateral versus unilateral rehabilitation with an upper limb wearable robotic system. IEEE Trans Neural Syst Rehabil Eng. 2013 Mar;21(2):153-64.
   
3. Tennant JN, et. al, Reliability and validity of a mobile phone for radiographic assessment of ankle injuries: a randomized inter- and intraobserver agreement study. Foot Ankle Int. 2013 Feb;34(2):228-33.
   

• Clinical bioinformatcs of human health and disease
• Model systems for understanding biology
  
• The practice of bioinformatics
• Unintended Consequences
  

1. Blair DR, et. al, A nondegenerate code of deleterious variants in mendelian Loci contributes to complex disease risk. Cell. 2013 Sep 26;155(1):70-80.*

1. Yuan Y, et. al, Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling. Sci Transl Med. 2012 Oct 24;4(157):157ra143.*
2. Irshad S, et. al, A molecular signature predictive of indolent prostate cancer. Sci Transl Med. 2013 Sep 11;5(202):202ra122.*
3. Frattini V, et. al, The integrated landscape of driver genomic alterations in glioblastoma. Nat Genet. 2013 Oct;45(10):1141-9.*
   
4. Hu J, et. al, Heterogeneity of tumor-induced gene expression changes in the human metabolic network. Nat Biotechnol. 2013 Jun;31(6):522-9.*

1. Gilman SR, et. al, Diverse types of genetic variation converge on functional gene networks involved in schizophrenia. Nat Neurosci. 2012 Dec;15(12):1723-8.*

1. Cassa CA, et. al, A novel, privacy-preserving cryptographic approach for sharing sequencing data. J Am Med Inform Assoc. 2013 Jan 1;20(1):69-76.
   
2. Samwald M, et. al, Pharmacogenomics in the pocket of every patient? A prototype based on quick response codes. J Am Med Inform Assoc. 2013 May 1;20(3):409-12.
   

1. Gymrek M, et. al, Identifying personal genomes by surname inference. Science. 2013 Jan 18;339(6117):321-4. doi: 10.1126/science.1229566.

JAMIA - Journal of the American Medical Informatics Association

1. Witten DM, et. al, Scientific research in the age of omics: the good, the bad, and the sloppy. J Am Med Inform Assoc. 2013 Jan 1;20(1):125-7.
   
2. White RW, et. al, Web-scale pharmacovigilance: listening to signals from the crowd. J Am Med Inform Assoc. 2013 May 1;20(3):404-8.
   
3. Radley DC, et. al, Reduction in medication errors in hospitals due to adoption of computerized provider order entry systems. J Am Med Inform Assoc. 2013 May 1;20(3):470-6. 
   
4. Embi PJ, et. al, Computerized provider documentation: findings and implications of a multisite study of clinicians and administrators. J Am Med Inform Assoc. 2013 Jul-Aug;20(4):718-26.
   
5. Deutsch MB, et. al, Electronic medical records and the transgender patient: recommendations from the World Professional Association for Transgender Health EMR Working Group. J Am Med Inform Assoc. 2013 Jul-Aug;20(4):700-3.
   

1. Rothman MJ, et. al, Development and validation of a continuous measure of patient condition using the Electronic Medical Record. J Biomed Inform. 2013 Oct;46(5):837-48.
   
2. Weiskopf NG, et. al, Defining and measuring completeness of electronic health records for secondary use. J Biomed Inform. 2013 Oct;46(5):830-6. 
   
3. Friedman C, et. al, Natural language processing: state of the art and prospects for significant progress, a workshop sponsored by the National Library of Medicine. J Biomed Inform. 2013 Oct;46(5):765-73.
   
4. Post AR, et. al, The Analytic Information Warehouse (AIW): a platform for analytics using electronic health record data. J Biomed Inform. 2013 Jun;46(3):410-24.
   
5. Valizadegan H, et. al, Learning classification models from multiple experts. J Biomed Inform. 2013 Sep 13. pii: S1532-0464(13)00122-6.
   

1. Ackerman SL, et. al, Benefit or burden? A sociotechnical analysis of diagnostic computer kiosks in four California hospital emergency departments. Soc Sci Med. 2012 Dec;75(12):2378-85.
   
2. Novak LL, et. al, Mediation of adoption and use: a key strategy for mitigating unintended consequences of health IT implementation. J Am Med Inform Assoc. 2012 Nov-Dec;19(6):1043-9.
   
   

• Primary PubMed search string:  randomized controlled trial[ptyp] AND (telemedicine[mh] OR informatics[tiab] OR medical informatics[mh] OR internet[ti] OR mobile[ti])
• Secondary PubMed search string: randomized[ti] AND (telemedicine[mh] OR informatics[tiab] OR medical informatics[mh])

• Primary PubMed search string: computational biology[mh] NOT (review[pt] OR letter[pt] OR case reports[pt] OR editorial[pt])
• Also (genomic[ti] OR genome[ti] OR bioinformatic*[ti]), limited to the core clinical journals.
• Secondary PubMed search string: computational biology[mh] AND (letter[pt] OR editorial[pt])
• To see which articles were generating more discussion, follow-up with consideration of key science blogs and news sites