Publications:

  • Journal
  1. Mingyong Han, Xiaohu Gao, Jack Su, and Shuming Nie, Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules, Nat. Biotechnol. 2001, 19, 631-635.
  2. Xiaohu Gao, Warren Chan, and Shuming Nie, Quantum-dot nanocrystals for ultrasensitive biological labeling and multicolor optical encoding, J. Biomed. Optics 2002, 7, 532–537.
  3. Warren Chan, Dustin Maxwell, Xiaohu Gao, Robert Bailey, Mingyong Han, and Shuming Nie, Luminescent quantum dots for multiplexed biological detection and imaging, Curr. Opin. Biotechnol. 2002, 13, 40-46.
  4. Xiaohu Gao, and Shuming Nie, Molecular profiling of single cells and tissue specimens with quantum dots, Trends Biotechnol. 2003, 21, 371-373.
  5. Xiaohu Gao, and Shuming Nie, Doping mesoporous materials with multicolor quantum dots, J. Phys. Chem. B 2003, 107, 11575-11578.
  6. Xiaohu Gao, and Shuming Nie, QD-encoded mesoporous beads with high brightness and uniformity: rapid readout by flow cytometry, Anal. Chem.2004,76, 2406-2410.
  7. Xiaohu Gao, Yuanyuan Cui, Richard Levenson, Leland Chung, and Shuming Nie, In vivo cancer targeting and imaging with semiconductor quantum dots, Nat. Biotechnol. 2004, 22, 969-976.
  8. Andrew Smith, Xiaohu Gao, and Shuming Nie, Quantum-dot nanocrystals for in-vivo molecular and cellular imaging, Photochem. Photobiol. 2004, 80, 377-385.
  9. Xiaohu Gao, Lily Yang, John A. Petros, Fray F. Marshall, Jonathan W. Simons, Leland Chung, and Shuming Nie, In vivo molecular and cellular imaging with quantum dots, Curr. Opin. Biotechnol. 2005, 16, 63-72.
  10. Andrew M Smith, Shivang Dave, Shuming Nie, Lawrence True and Xiaohu Gao, Multicolor quantum dots for molecular diagnostics of cancer, Expert Rev. Mol. Diagn. 2006, 6, 231-244.
  11. Dardo E. Ferrara, Daiana Weiss, Peter H. Carnell, Ray P.Vito, David Vega, Xiaohu Gao, Shuming Nie and W. Robert Taylor, Quantitative 3D fluorescence technique for the analysis of en face preparations of arterial walls using quantum dot nanocrystals and two-photon
    excitation laser scanning microscopy, Am. J. Physiol. 2006, 290, R114-R123.
  12. Matthew N. Rhyner, Andrew M. Smith, Xiaohu Gao, Hui Mao, Lily Yang and Shuming Nie, Quantum dots and multifunctional nanoparticles: new contrast agents for tumor Imaging, Nanomedicine 2006, 1, 209-217.
  13. Maksym V Yezhelyev, Xiaohu Gao, Yun Xing, Ahmad Al-Hajj, Shuming Nie and Ruth M O'Regan, Emerging use of nanoparticles in diagnosis and treatment of breast cancer, Lancet Oncology 2006, 7, 657-667.
  14. Lawrence D. True and Xiaohu Gao, Quantum dots for molecular pathology-their time has arrived,J. Mol. Diagn. 2007, 9, 7-11.
  15. Maksym V. Yezhelyev, Ahmad Al-Hajj, Caroline Morris, Adam I. Marcus, Tonqrui Liu, Melinda Lewis, Cynthia Cohen, Pasha Zrazhevskiy, JonathanW. Simons, Andre Rogatko, Shuming Nie, Xiaohu Gao and Ruth M. O’Regan, In situ molecular profiling of breast cancer biomarkers with multicolor quantum dots, Adv. Mater., 2007, 19, 3146–3151.
  16. Jian Yang, Jonathan Gunn, Shivang R. Dave, Miqin Zhang, Y. Andrew Wang and Xiaohu Gao, Ultrasensitive detection and molecular imaging with magnetic nanoparticles, Analyst 2008, 133, 154-160.
  17. Lifeng Qi, and Xiaohu Gao, Emerging application of quantum dots for drug delivery and therapy," Expert Opin. Drug Delivery, 2008, 5,263-267.
  18. Jian Yang, Shivang R. Dave, and Xiaohu Gao, Quantum dot nanobarcodes: epitaxial assembly of nanoparticle-polymer complexes in homogeneous solution,J. Am. Chem. Soc., 2008, 130, 5286-5292.
  19. Lifeng Qi, and Xiaohu Gao, Quantum Dot-Amphipol Nanocomplex for Intracellular Delivery and Real-Time Imaging of siRNA,ACS Nano, 2008, 2, 1403-1010. ACS-Podcast http://pubs.acs.org/journals/ancac3/podcasts/index.html (Episode 12).
  20. Maksym Yezhelyev, Lifeng Qi, Ruth M. O’Regan, Shuming Nie, and Xiaohu Gao, Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging,J. Am. Chem. Soc., 2008, 130, 9006-9012.
  21. Lily Yang, Hui Mao, Y. Andrew Wang, Zehong Cao, Xianghong Peng, Xiaoxia Wang, Hongwei Duan, Chunchun Ni, Qingan Yuan, Gregory Adams, Mark Q. Smith, William C. Wood, Xiaohu Gao, Shuming Nie, Single chain epidermal growth factor receptor antibody conjugated nanoparticles for in vivo tumor targeting and imaging, Small, 2009, 5, 235-243.
  22. Lily Yang, Xianghong Peng, Y. Andrew Wang, Xiaoxia Wang, Zhehong Cao, Chunchun Ni, Prasanthi Karna, Xinjian Zhang, William C. Wood, Xiaohu Gao, Shuming Nie, Hui Mao, Receptor-targeted nanoparticles for in vivo imaging of breast cancer, Clin. Cancer Res., 2009, 15, 4722-4732.
  23. Lily Yang, Hui Mao, Zhehong Cao, Y. Andrew Wang, Xianghong Peng, Xiaoxia Wang, Hari K. Sajja, Liya Wang, Hongwei Duan, Chunchun Ni, Charles A. Staley, William C. Wood, Xiaohu Gao, Shuming Nie, Molecular imaging of pancreatic cancer in an animal model using targeted multifunctional nanoparticles, Gastroenterology, 2009, 136, 1514-1525.
  24. Xiaoge Hu, Pavel Zrazhevskiy, Xiaohu Gao, Encapsulation of single quantum dots with mesoporous silica, Ann. Biomed. Eng., 2009, 37, 1960-1966.
  25. Shivang R. Dave and Xiaohu Gao, Monodisperse magnetic nanoparticles for biodetection, imaging and drug delivery, a versatile and evolving technology, Wiley Interdisciplinary Reviews: Nanomedicine, 2009, 1, 583-609.
  26. Pavel Zrazhevskiy and Xiaohu Gao, Quantum dots for cancer molecular imaging, Minerva Biotecnologica, 2009, 21, 37-52.
  27. Yongdong Jin and Xiaohu Gao, Plasmonic fluorescent quantum dots, Nat. Nanotechnol. 2009, 4, 571-576. representative News from Biophotonics http://www.photonics.com/Content/ReadArticle.aspx?ArticleID=39997, C&EN News http://pubs.acs.org/cen/science/87/8731scic4.html
  28. Pavel Zrazhevskiy and Xiaohu Gao, Multifunctional quantum dots for personalized medicine, Nano Today, 2009, 4, 414-428.
  29. Yongdong Jin and Xiaohu Gao, Spectrally tunable leakage-free gold nanocontainers, J. Am. Chem. Soc., 2009, 131, 17774–17776.
  30. Yongdong Jin , Congxian Jia , Shengwen Huang, Matt O'Donnell and Xiaohu Gao, Multifunctional nanoparticles as coupled contrast agents, Nat. Commun. 2010, 10.1038/ncomms1042. representative news from US News & World Report
  31. Shang-Hsiu Hu and Xiaohu Gao, Nanocomposites with spatially separated functionalities for combined imaging and magnetolytic therapy, J. Am. Chem. Soc., 2010, 132, 7234-7237.
  32. Pavel Zrazhevskiy, Mark Sena and Xiaohu Gao, Designing multifunctional quantum dots for bioimaging, detection, and drug delivery, Chem. Soc. Rev. 2010, 39, 4326-4354.
  33. Shang-Hsiu Hu and Xiaohu Gao, Stable encapsulation of quantum dot barcodes with silica shells, Adv. Func. Mater. 2010, 20, 3721-3726.
  34. Xiaoge Hu and Xiaohu Gao, Silica−polymer dual layer-encapsulated quantum dots with remarkable stability, ACS Nano 2010, 4, 6080-6086.
  35. Gilad Zorn, Shivang Dave, Xiaohu Gao, and David Castner, Method for determining the elemental composition and distribution in semiconductor core-shell quantum dots, Anal. Chem. 2011, 83, 866-873.
  36. Hongyan Liu and Xiaohu Gao, Engineering Monovalent Quantum Dot-Antibody Bioconjugates with a Hybrid Gel System, Bioconjugate Chem. 2011, 22, 510-517.
  37. Xiaoge Hu and Xiaohu Gao, Multilayer coating of gold nanorods for combined stability and biocompatibility, Phys. Chem. Chem. Phys. 2011, DOI: 10.1039/C0CP02434A.
  38. Christine E Probst, Pavel Zrazhevskiy, and Xiaohu Gao, Rapid multitarget immunomagnetic separation through programmable DNA linker displacement, J. Am. Chem. Soc., 2011
  39. Vashali Bagalkot, and Xiaohu Gao, siRNA-aptamer chimeras on nanoparticles: preserving targeting functionality for effective gene silencing, ACS Nano, 2011
  • Conference Proceedings
  1. Xiaohu Gao, Mingyong Han, and Shuming Nie, "Optically encoded microspheres for high-throughput analysis of genes and proteins," Proc. SPIE 2001, 4626, 210-217.
  2. Xiaohu Gao, and Shuming Nie, "Semiconductor quantum dots for multicolor fluorescence imaging and spectroscopy of single cancer cells," MRS Proceedings, 2003, 773, N 1.5.
  3. Amit Agrawal, Xiaohu Gao, Nitin Nitin, Gang Bao, and Shuming Nie, "Quantum dots and fret-nanobeads for probing genes, proteins, and drug targets in single cells," Proceedings of IMECE, 2003, IMECE2003-43598.
  4. Xiaohu Gao and Shuming Nie, "Long-circulating QD probes for in vivo tumor imaging," Proc. SPIE 2004, 5593, 292-299.
  5. Aileen Wu and Xiaohu Gao, " Multiplexed and quantitative study of biomarker expression in tumor specimens using quantum dots," SPIE 2006, 6096: 257-265.
  6. Xiaohu Gao, “Traceable drug delivery, lighting the way with Qdots,” National Academy of Engineering Frontiers of Engineering 2008
  • Invited Book Chapters
  1. Xiaohu Gao, and Shuming Nie, “Quantum-dot-encoded beads” in Bionanotechnology Protocols, Humana Press Inc. 2003.
  2. Xiaohu Gao, and Shuming Nie, “Semiconductor quantum dots and optically encoded microbeads for gene expression analysis” in Perspectives in Gene Expression, Eaton Publishing 2003.
  3. Xiaohu Gao, and Shuming Nie, "Luminescent quantum dots for biological labeling," in NanoBiotechnology, Wiley-VCH Publishers, 2004.
  4. Warren Chan, Xiaohu Gao, and Shuming Nie, “Quantum dots as fluorescent labels for molecular biotechnology and bioengineering,” in Colloids and Colloid Assemblies: Synthesis, Modification, Organization, and Application, Wiley-VCH Publishers, 2004.
  5. Xiaohu Gao, Leland WK Chung and Shuming Nie, "Quantum Dots for In-vivo Molecular and Cellular Imaging," in Methods in Molecular Biology, Humana Press Inc. 2005.
  6. Xiaohu Gao, Max Yezhleyev, Yun Xing and Shuming Nie, “Bioconjugated Quantum Dots for Sensitive and Multiplexed Immunoassays,” in A Reference Book for Immunoassay and Other Bioanalytical Methods, Marcel Dekker Inc. 2005.
  7. Xiaohu Gao and Shuming Nie, "Nanotechnolog in chemistry, biology and medicine," in Microsystems and Nanotechnology, Chapter written in Chinese, Science Press, China, 2005.
  8. Xiaohu Gao, Yun Xing, Leland CW Chung and Shuming Nie, “Quantum Dot Nanotechnology for Prostate Cancer” in Prostate Cancer: Novel Biology, Genetics and Therapy 2005.
  9. Amit Agrawal, Yun Xing, Xiaohu Gao, and Shuming Nie, “Quantum dots,” in Nanotechnology in Biology and Medicine, CRC press. 2006.
  10. Gang Ruan, Amit Agrawal, Andrew M. Smith, Xiaohu Gao, and Shuming Nie, "Quantum dots as fluorescent labels for molecular and cellular imaging," in Reviews in Fluorescence , Annual volumes 2006. 2006.
  11. Xiaohu Gao and Shivang Dave, "Quantum dots for cancer molecular imaging," in Biological and Biomedical Applications of Engineered Nanostructures, Landes Bioscience/Eurekah, 2006.
  12. Pavel Zrazhevskiy and Xiaohu Gao, "Molecular profiling of cancer cells and tissues using multicolor quantum dots," in Nanomaterials: Inorganic and Bioinorganic Perspectives, John Wiley & Sons, Ltd. 2007.
  13. Shivang R. Dave, Collin White, Terrance Kavanagh, Xiaohu Gao, “Luminescent quantum dots for molecular toxicology,” , in New Technologies for Toxicology Testing, edited by M. Balls, R. Combes, Landes Bioscience 2008.
  14. Shivang R. Dave, Xiaohu Gao, “Monodisperse magnetic nanoparticles for biodetection, imaging and drug delivery – a versatile and evolving technology,” in Wiley Interdisciplinary Reviews: Nanomedicine, edited by Amna Ahmad, John Wiley & Sons, Inc. 2008.
  15. Pavel Zrazhevskiy and Xiaohu Gao. Bioconjugated quantum dots for tumor molecular imaging and profiling, in Oxford Handbook of Nanoscience and Technology: Frontiers and Advances, edited by A. Narlikar and Y. Fu, Oxford University Press, UK 2008.
  • Patents
  1. Xiaohu Gao, and Shuming Nie, “Porous materials embedded with nanospecies, methods of fabrication thereof, and methods of use thereof,”United States Patent number 7,037,729.
  2. Mingyong Han, Xiaohu Gao, and Shuming Nie, “Methods of preparing multicolor quantum dot tagged beads and conjugates thereof,“ Filed in 2001, US and International Patents Pending.
  3. Xiaohu Gao, and Shuming Nie, “Bioconjugated nanostructures, methods of fabrication thereof, and methods of use thereof,” Filed in 2003, US and International Patents Pending.
  4. Xiaohu Gao, and Shuming Nie, “Multimodality nanostructures, methods of fabrication thereof, and methods of use thereof,” Filed in 2004, US and International Patents Pending.

 

Invited Talks:

  1. “Highly luminescent quantum dot nanocrystals and bio-analytical applications,” Pittsburgh Conference, New Orleans, LA, 2001.
  2. “Luminescent quantum dots for optical encoding and molecular imaging,” Department of Chemistry and Department of Radiology, University of Pennsylvania, 2003.
  3. “Luminescent quantum dots for optical encoding and cancer profiling,” American Chemical Society's 225th National Meeting, Industry Pavilion, New Orleans, LA, 2003.
  4. “Optical-encoded microbeads for multiplexed analysis of genes, proteins, and cells,” Materials Research Society Meeting, San Francisco, CA, 2003.
  5. “ Optical-encoded microbeads for multiplexed analysis of genes, proteins, and cells,” SmallTalks2003, San Jose, CA, 2003.
  6. “Luminescent quantum dots for multicolor and ultrasensitive cellular imaging,” ASME International Mechanical Engineering Congress and R and D Expo, Washington , D.C. , 2003.
  7. “Fluorescent quantum dots for molecular imaging and multiplexed gene screening,” NIEHS-CMGCC / NCI-MMHCC Mouse Phenotyping Forum, Austin, TX, 2004.
  8. “Quantum Dot-Encoded Beads as Invisible Taggants,” DARPA workshop Nanoparticle Taggants for Military Applications, San Francisco, CA, 2004.
  9. “Probing single molecules and single cells with quantum dots,” 228th ACS National Meeting, Philadelphia, PA, 2004.
  10. “Luminescent quantum dots and optically encoded beads for multiplexed biological detection and imaging,” International Symposium on Optics East, Philadelphia, PA, 2004 (Keynote lecture).
  11. “Luminescent quantum dots for molecular imaging and optical encoding,” Department of Biomedical engineering, University of California, Davis, CA, 2004.
  12. “Biomedical applications of nanomaterials,” USAMRMC TATRC Nanomedicine Integrated Research Team Meeting, Frederick, MD, 2005.
  13. “Bioconjugated quantum dots and nanoparticle probes for molecular and cellular imaging,” 229th American Chemical Society National Meeting, Novel Directions in Photonics: Nanophotonics and Biophotonics, San Diego, CA, 2005.
  14. “Luminescent quantum dots for molecular imaging and optical encoding,” Department of Biomedical engineering, University of Florida, Gainesville, FL, 2005.
  15. “Multicolor quantum dots for optical barcoding and molecular analysis,” 229th American Chemical Society National Meeting, ACS Nobel Laureate Signature Award Symposium: Spectroscopy at the Nanoscale, San Diego, CA, 2005.
  16. “Luminescent quantum dots for molecular imaging and optical encoding,” Department of Biomedical engineering, University of Wisconsin, Madison, WI, 2005.
  17. “Luminescent quantum dots for molecular imaging and optical encoding,” Department of Bioengineering, Stanford University, Palo Alto, CA, 2005.
  18. “Luminescent quantum dots for molecular imaging and drug delivery,” Cancer Center, University of Colorado at Denver, 2005.
  19. “Multifunctional nanoparticles for imaging and therapeutics,” Fred Hutchinson Cancer Research Center, Seattle, WA, 2005.
  20. “Luminescent quantum dots for cellular and molecular imaging,” Photonics West, San Jose, CA 2006.
  21. “Molecular imaging and drug delivery using multifunctional nanoparticles,” Department of Chemistry, Arizona State University, Tempe, AZ, 2006.
  22. “Probing single molecules and single cells with quantum dots”, International Workshop on Single Molecule Analysis, Okinawa, Japan, 2006.
  23. “Luminescent quantum dots for cellular and molecular imaging,” Focus on Microscopy, Perth, Australia 2006 (plenary session) 2006.
  24. “Cancer nanotechnology,” Department of Chemistry, Nankai Univeristy, Tianjin, China, 2006.
  25. “Quantum dot nanoparticles for molecular imaging,” Particles2006, Orlando, FL, 2006.
  26. “Multifunctional nanoparticles for molecular imaging and bioengineering,” Department of Chemistry, Western Washington University, WA, 2007.
  27. “Functional nanostructures and their biomedical applications,” Workshop on Safety, Health, & Environmental Aspects of Engineered Nanomaterials. Singapore, 2007.
  28. "Luminescent Quantum Dots for Cancer Research” Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 2007.
  29. “Luminescent quantum dots for molecular imaging and ultrasensitive detection,” Institute of Bioengineering and Nanotechnology, Singapore, 2007.
  30. "Nanoparticle probes for molecular imaging and therapy," the Pacific Northwest Association of Toxicologists 2007 Annual Meeting, Seattle, WA 2007.
  31. "Nanoparticle probes for molecular imaging and therapy," Biomedical Engineering Society Annual Meeting, Los Angeles, CA 2007 .
  32. "Luminescent quantum dots for molecular imaging and cellular imaging," American Vacuum Society 54th International Symposium and Exhibition, Seattle, WA 2007.
  33. “Scrutinizing cancer with quantum dot technology,” The 12th Shizuoka Forum on Health and Longevity, Hamamatsu, Japan (plenary session) 2007.
  34. “Multifunctional QDs for molecular imaging and siRNA delivery,” Biomedical Optics Topical Meeting (BIOMED), St. Petersburg, Fl, (plenary session) 2008.
  35. “Quantum dot nanobarcodes” 2008 Emory-GT Frontiers of Cancer Nanotechnology Symposium, Atlanta, GA 2008.
  36. "Simultaneous imaging and delivery of siRNA with quantum dots," Particles 2008, Orlando, Fl, 2008.
  37. "Fluorescent quantum dots for biodetection and drug delivery," Chinese Chemical Society annual meeting, Tianjin, 2008.
  38. "Multifunctional Qdots and their bioapplications," Institute of Nanobiotechnology(INBT), Tianjin University, 2008.
  39. “QD probes for efficient delivery and real-time imaging of siRNA,” 236th American Chemical Society National Meeting, Philadelphia, PA, 2008.
  40. “Traceable delivery of siRNA,” 5th Micro Nano Breakthrough Conference, Vancouver, WA, 2008.
  41. “Traceable drug delivery, lighting the way with Qdots,” National Academy of Engineering Frontiers of Engineering symposia, Albuquerque, NM, 2008.
  42. "Multifunctional QDs for Molecular Imaging & siRNA Delivery" IMRE, Singapore, 2008.
  43. "Multifunctional Qdots for siRNA Delivery & Imaging" Asia Nano, Singapore, 2008.
  44. "Luminescent Q-dots for molecular imaging and traceable drug delivery" Stem Cells & Cell Signaling, Seattle, WA, 2009.
  45. "Multimodality nanoparticles" China-US Nanotechnology Workshop, Hefei, China, 2009.
  46. "Multifunctional nanoparticles for imaging" Microscopy & Microanalysis, Richmond, VA 2009.
  47. "Traceable Sirna Delivery with Quantum Dots" 31st Annual International IEEE EMBS Conference, Minneapolis, MN 2009.
  48. "QD Barcodes for Biosensing and Detection" 31st Annual International IEEE EMBS Conference, Minneapolis, MN 2009.
  49. "Multifunctional nanoparticles for photomedicine" European Congress of Photobiology, Wroclaw, Poland, 2009.
  50. "Bioengineering curriculum and Research on nanomedicine" Tianjin University, China, 2009.
  51. "Multifunctional nanoparticles for imaging and drug delivery" Department of Biomedical Engineering, Washington University, St. Louis, 2009
  52. "Multifunctional nanoparticles for imaging and drug delivery" Korean University, Seoul, Korea, 2009
  53. "Engineering multifunctional nanoprobes for molecular imaging" Korea molecular imaging society meeting, Korea 2009
  54. "Smart nanoparticles for drug delivery" Kyungpook National University-UW Bioengineering Convergence Meeting, Daegu, Korea 2009
  55. "Multifunctional nanoparticles for imaging, detection, and therapeutics" Department of Bioengineering, University of Pennsylvania, 2009.
  56. Multifunctional nanoparticles for imaging and drug delivery” Beijing University of Chemical Technology, Beijing, 2010
  57. Smart nanoparticle for simultaneous cancer imaging and therapy” Department of Chemistry, University of Texas, Dallas, 2010
  58. Multifunctional nanoparticles for cancer nanotechnology” Center for Clinical and Translational Science, University of Illinois at Chicago, 2010
  59. Multifunctional nanoparticles for biomedical imaging and drug delivery” National Cheng Kung University, Taiwan, 2010
  60. Composite nanoparticles and their Applications” 5th US-Sino nanotechnology workshop, Suzhou, China 2010
  61. Multifunctional nanoparticles, coupled behavior and applications” Materials Research Society meeting, San Francisco, CA 2010
  62. Multifunctional nanoparticles for imaging and therapeutics, TechConnect World 2010 Conferences and Expo: Nanotech2010, Microtech2010, Clean Technology 2010, BioNano2010, 2010
  63. Development of multimodality imaging probes,” Gordon Research Conference on Lasers in Medicine and Biology, Holderness, NH, 2010
  64. Multifunctional nanoparticles for cancer imaging and therapeutics, Department of Chemical & Biological Engineering, University of Alabama, Tuscaloosa, AL 2010
  65. Multimodality nanoprobes for molecular imaging, Biomarker Assay Development, San Diego, CA, 2011
  66. Multifunctional nanoparticles for molecular imaging and therapy, Vanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University, Nashville, TN 2011
  67. Multifunctional discrete nanoparticles, ChinaNano, Beijing, China 2011
  68. Engineering multifunctional and monovalent nanoprobes, 6th US-Sino nanotechnology workshop, Jilin, China 2011