Peer reviewed journal publications

  1. Mingyong Han, Xiaohu Gao, Jack Su, and Shuming Nie, Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules, Nat. Biotechnol. 2001, 19, 631-635.
  2. Xiaohu Gao, Warren Chan, and Shuming Nie, Quantum-dot nanocrystals for ultrasensitive biological labeling and multicolor optical encoding, J. Biomed. Optics 2002, 7, 532–537.
  3. Warren Chan, Dustin Maxwell, Xiaohu Gao, Robert Bailey, Mingyong Han, and Shuming Nie, Luminescent quantum dots for multiplexed biological detection and imaging, Curr. Opin. Biotechnol. 2002, 13, 40-46.
  4. Xiaohu Gao, and Shuming Nie, Molecular profiling of single cells and tissue specimens with quantum dots, Trends Biotechnol. 2003, 21, 371-373.
  5. Xiaohu Gao, and Shuming Nie, Doping mesoporous materials with multicolor quantum dots, J. Phys. Chem. B 2003, 107, 11575-11578.
  6. Xiaohu Gao, and Shuming Nie, QD-encoded mesoporous beads with high brightness and uniformity: rapid readout by flow cytometry, Anal. Chem.2004,76, 2406-2410.
  7. Xiaohu Gao, Yuanyuan Cui, Richard Levenson, Leland Chung, and Shuming Nie, In vivo cancer targeting and imaging with semiconductor quantum dots, Nat. Biotechnol. 2004, 22, 969-976.
  8. Andrew Smith, Xiaohu Gao, and Shuming Nie, Quantum-dot nanocrystals for in-vivo molecular and cellular imaging, Photochem. Photobiol. 2004, 80, 377-385.
  9. Xiaohu Gao, Lily Yang, John A. Petros, Fray F. Marshall, Jonathan W. Simons, Leland Chung, and Shuming Nie, In vivo molecular and cellular imaging with quantum dots, Curr. Opin. Biotechnol. 2005, 16, 63-72.
  10. Andrew M Smith, Shivang Dave, Shuming Nie, Lawrence True and Xiaohu Gao, Multicolor quantum dots for molecular diagnostics of cancer, Expert Rev. Mol. Diagn. 2006, 6, 231-244.
  11. Dardo E. Ferrara, Daiana Weiss, Peter H. Carnell, Ray P.Vito, David Vega, Xiaohu Gao, Shuming Nie and W. Robert Taylor, Quantitative 3D fluorescence technique for the analysis of en face preparations of arterial walls using quantum dot nanocrystals and two-photon
    excitation laser scanning microscopy, Am. J. Physiol. 2006, 290, R114-R123.
  12. Matthew N. Rhyner, Andrew M. Smith, Xiaohu Gao, Hui Mao, Lily Yang and Shuming Nie, Quantum dots and multifunctional nanoparticles: new contrast agents for tumor Imaging, Nanomedicine 2006, 1, 209-217.
  13. Maksym V Yezhelyev, Xiaohu Gao, Yun Xing, Ahmad Al-Hajj, Shuming Nie and Ruth M O'Regan, Emerging use of nanoparticles in diagnosis and treatment of breast cancer, Lancet Oncology 2006, 7, 657-667.
  14. Lawrence D. True and Xiaohu Gao, Quantum dots for molecular pathology-their time has arrived,J. Mol. Diagn. 2007, 9, 7-11.
  15. Maksym V. Yezhelyev, Ahmad Al-Hajj, Caroline Morris, Adam I. Marcus, Tonqrui Liu, Melinda Lewis, Cynthia Cohen, Pasha Zrazhevskiy, JonathanW. Simons, Andre Rogatko, Shuming Nie, Xiaohu Gao and Ruth M. O’Regan, In situ molecular profiling of breast cancer biomarkers with multicolor quantum dots, Adv. Mater., 2007, 19, 3146–3151.
  16. Jian Yang, Jonathan Gunn, Shivang R. Dave, Miqin Zhang, Y. Andrew Wang and Xiaohu Gao, Ultrasensitive detection and molecular imaging with magnetic nanoparticles, Analyst 2008, 133, 154-160.
  17. Lifeng Qi, and Xiaohu Gao, Emerging application of quantum dots for drug delivery and therapy," Expert Opin. Drug Delivery, 2008, 5,263-267.
  18. Jian Yang, Shivang R. Dave, and Xiaohu Gao, Quantum dot nanobarcodes: epitaxial assembly of nanoparticle-polymer complexes in homogeneous solution,J. Am. Chem. Soc., 2008, 130, 5286-5292.
  19. Lifeng Qi, and Xiaohu Gao, Quantum Dot-Amphipol Nanocomplex for Intracellular Delivery and Real-Time Imaging of siRNA,ACS Nano, 2008, 2, 1403-1010. ACS-Podcast http://pubs.acs.org/journals/ancac3/podcasts/index.html (Episode 12).
  20. Maksym Yezhelyev, Lifeng Qi, Ruth M. O’Regan, Shuming Nie, and Xiaohu Gao, Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging,J. Am. Chem. Soc., 2008, 130, 9006-9012.
  21. Lily Yang, Hui Mao, Y. Andrew Wang, Zehong Cao, Xianghong Peng, Xiaoxia Wang, Hongwei Duan, Chunchun Ni, Qingan Yuan, Gregory Adams, Mark Q. Smith, William C. Wood, Xiaohu Gao, Shuming Nie, Single chain epidermal growth factor receptor antibody conjugated nanoparticles for in vivo tumor targeting and imaging, Small, 2009, 5, 235-243.
  22. Lily Yang, Xianghong Peng, Y. Andrew Wang, Xiaoxia Wang, Zhehong Cao, Chunchun Ni, Prasanthi Karna, Xinjian Zhang, William C. Wood, Xiaohu Gao, Shuming Nie, Hui Mao, Receptor-targeted nanoparticles for in vivo imaging of breast cancer, Clin. Cancer Res., 2009, 15, 4722-4732.
  23. Lily Yang, Hui Mao, Zhehong Cao, Y. Andrew Wang, Xianghong Peng, Xiaoxia Wang, Hari K. Sajja, Liya Wang, Hongwei Duan, Chunchun Ni, Charles A. Staley, William C. Wood, Xiaohu Gao, Shuming Nie, Molecular imaging of pancreatic cancer in an animal model using targeted multifunctional nanoparticles, Gastroenterology, 2009, 136, 1514-1525.
  24. Xiaoge Hu, Pavel Zrazhevskiy, Xiaohu Gao, Encapsulation of single quantum dots with mesoporous silica, Ann. Biomed. Eng., 2009, 37, 1960-1966.
  25. Shivang R. Dave and Xiaohu Gao, Monodisperse magnetic nanoparticles for biodetection, imaging and drug delivery, a versatile and evolving technology, Wiley Interdisciplinary Reviews: Nanomedicine, 2009, 1, 583-609.
  26. Pavel Zrazhevskiy and Xiaohu Gao, Quantum dots for cancer molecular imaging, Minerva Biotecnologica, 2009, 21, 37-52.
  27. Yongdong Jin and Xiaohu Gao, Plasmonic fluorescent quantum dots, Nat. Nanotechnol. 2009, 4, 571-576. representative News from Biophotonics http://www.photonics.com/Content/ReadArticle.aspx?ArticleID=39997, C&EN News http://pubs.acs.org/cen/science/87/8731scic4.html
  28. Pavel Zrazhevskiy and Xiaohu Gao, Multifunctional quantum dots for personalized medicine, Nano Today, 2009, 4, 414-428.
  29. Yongdong Jin and Xiaohu Gao, Spectrally tunable leakage-free gold nanocontainers, J. Am. Chem. Soc., 2009, 131, 17774–17776.
  30. Yongdong Jin , Congxian Jia , Shengwen Huang, Matt O'Donnell and Xiaohu Gao, Multifunctional nanoparticles as coupled contrast agents, Nat. Commun. 2010, 10.1038/ncomms1042. representative news from US News & World Report
  31. Shang-Hsiu Hu and Xiaohu Gao, Nanocomposites with spatially separated functionalities for combined imaging and magnetolytic therapy, J. Am. Chem. Soc., 2010, 132, 7234-7237.
  32. Pavel Zrazhevskiy, Mark Sena and Xiaohu Gao, Designing multifunctional quantum dots for bioimaging, detection, and drug delivery, Chem. Soc. Rev. 2010, 39, 4326-4354.
  33. Shang-Hsiu Hu and Xiaohu Gao, Stable encapsulation of quantum dot barcodes with silica shells, Adv. Func. Mater. 2010, 20, 3721-3726.
  34. Xiaoge Hu and Xiaohu Gao, Silica−polymer dual layer-encapsulated quantum dots with remarkable stability, ACS Nano 2010, 4, 6080-6086.
  35. Gilad Zorn, Shivang Dave, Xiaohu Gao, and David Castner, Method for determining the elemental composition and distribution in semiconductor core-shell quantum dots, Anal. Chem. 2011, 83, 866-873.
  36. Hongyan Liu and Xiaohu Gao, Engineering Monovalent Quantum Dot-Antibody Bioconjugates with a Hybrid Gel System, Bioconjugate Chem. 2011, 22, 510-517.
  37. Xiaoge Hu and Xiaohu Gao, Multilayer coating of gold nanorods for combined stability and biocompatibility, Phys. Chem. Chem. Phys. 2011, DOI: 10.1039/C0CP02434A.
  38. Christine E Probst, Pavel Zrazhevskiy, and Xiaohu Gao, Rapid multitarget immunomagnetic separation through programmable DNA linker displacement, J. Am. Chem. Soc., 2011
  39. Vashali Bagalkot, and Xiaohu Gao, siRNA-aptamer chimeras on nanoparticles: preserving targeting functionality for effective gene silencing, ACS Nano, 2011
  40. S.H. Hu, S.Y. Chen, and X.H. Gao , Multifunctional nanocapsules for simultaneous encapsulation of hydrophilic and hydrophobic compounds and on-demand release, ACS Nano , 2012, 6, 2558-2565.
  41. W.E. Smith, J. Brownell, C.C. White, Z. Afsharinejad, J. Tsai, X.H. Hu, S.J. Polyak, X.H. Gao , T.J. Kavanagh, D.L. Eaton, In vitro toxicity assessment of amphiphillic polymer-coated CdSe/ZnS quantum dots in two human liver cell models ACS Nano , 2012, 6, 9475-9484.
  42. Y. Jung, G. Guan, C.W. Wei, R. Reif, X.H. Gao, O'Donnell M, Wang RK. Multifunctional nanoprobe to enhance the utility of optical based imaging techniques, J. Biomed. Opt. 2012, 17(1):016015.
  43. J. Xia, I. Pelivanov, C. Wei, X. Hu, X.H. Gao, M. O'Donnell. Suppression of background signal in magnetomotive photoacoustic imaging of magnetic microspheres mimicking targeted cells, J. Biomed. Opt. 2012, 17(6):061224.
  44. C. Wei, J. Xia, I. Pelivanov, X. Hu, X.H. Gao, M. O'Donnell, Trapping and dynamic manipulation of polystyrene beads mimicking circulating tumor cells using targeted magnetic/photoacoustic contrast agents, J. Biomed. Opt. 2012, 17(10):101517.
  45. X.G. Hu, C.W. Wei, J.J. Xia, I. Pelivanov, M. O'Donnell, X.H. Gao, Trapping and photoacoustic detection of CTCs at the single cell per milliliter level with magneto-optical coupled nanoparticles, Small , 2012, 9, 2046-2052.
  46. C.E. Probst, P. Zrazhevskiy, V. Bagalkot, X.H. Gao, Quantum dots as a platform for nanoparticle drug delivery vehicle design, Adv. Drug Deliv. Rev. 2013, 65, 703-718.
  47. J. Qian, X.H. Gao, Triblock copolymer-encapsulated nanoparticles with outstanding colloidal stability for siRNA delivery, ACS Appl. Mater. Interfaces , 2013, 5, 2845-2852.
  48. P. Zrazhevskiy, X.H. Gao, Quantum dot imaging platform for single-cell molecular profiling, Nature Communications , doi: 10.1038/ncomms2635, 2013.
  49. X.H. Gao, Molecular Imaging with Multifunctional Nanoparticles, Clin. Chem. , 59, 1532-1533.
  50. LA McConnachie, CC White, D Botta, ME Zadworny, DP Cox, RP Beyer, XG Hu, DL Eaton, XH Gao, TJ Kavanagh, Heme oxygenase expression as a biomarker of exposure to amphiphilic polymer-coated CdSe/ZnS quantum dots, Nanotoxicology , 7, 181-191.
  51. CW Wei, J. Xia, I Pelivanov, C Jia, SW Huang, X Hu, X.H. Gao, and M. O'Donnell, M., Magnetomotive photoacoustic imaging: in vitro studies of magnetic trapping with simultaneous photoacoustic detection of rare circulating tumor cells. J. Biophoton ., 2013, 6, 513-522.
  52. LA McConnachie, D Botta, CC White, CS Weldy, HW Wilkerson, J. Yu, R. Dills, X. Yu, WC Griffith, EM Faustman, FM Farin, SE Gill, WC Parks, X Hu, X.H. Gao, D.L. Eaton, T.J. Kavanagh, The glutathione synthesis gene gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot–induced lung inflammation in mice. PLoS ONE 8, e64165.
  53. J. Li, J. Liu, C.W. Wei, B. Liu, M. O'Donnell and X.H. Gao, Emerging applications of conjugated polymers in molecular imaging, Phys. Chem. Chem. Phys ., 2013,15, 17006-17015.
  54. P. Zrazhevskiy, L.D. True, and X.H. Gao, Multicolor multicycle molecular profiling (M3P) with quantum dots for single-cell analysis, Nature Protocols , 8, 1852-1869, 2013.