Are you wondering how cells divide?
We use quantitative live imaging to understand how
cells get the right chromosomes during cell division
and to develop therapeutic interventions for cancer
Dynamic microtubules and microtubule dependeint
motor proteins drive the attachment, movement and
We use a number of high-resolution microscopic techniques, fluorescently tagged proteins and genome edited mammalian cells to answer the following questions:
How do microtubules and microtubule motors use the
energy of GTP and ATP to organize cellular contents?
How are dynamic microtubules spatially organized and
regulated within the cell and within the mitotic spindle?
How do microtubules and motors contribute to the
accuracy of chromosome segregation and to long-term
chromosome instability in living cells?
What therapies can we develop by exploiting our under-
standing of cell division and the cytoskeleton to treat disease.