Fragment cocktail information is available upon signing a legal agreement.
Download this form,
sign it, and return by it fax to Christophe Verlinde
at (206) 685 7002. Upon
agreement I will provide you with a username
and password for downloading the
fragment cocktail information.
The first published successes we obtained with our cocktails are described in
Bosch J., Robien M.A., Mehlin C., Boni E., Riechers A., Buckner F.S., Van Voorhis W.C.,
Myler P.J., Worthey E.A., DeTitta G., Luft J.R., Lauricella A., Gulde S., Anderson L.A.,
Kalyuzhniy O., Neely H.M., Ross J., Earnest T.N., Michael Soltis, Lori Schoenfeld, Zucker F.,
Merritt E.A., Fan E., Verlinde C.L.M.J., Hol W.G.J.(2006). Identifying Novel Lead Compounds
For Inhibiting Nucleoside 2-deoxyribosyltransferase In Trypanosoma brucei by Fragment
Cocktail Crystallography. J. Med. Chem. 49, 5939-5946. [PMID: 17004709 ].
In the fall of 2009 a paper will appear that described how we designed the cocktails and
lists our successes:
Verlinde C.L.M.J., Fan E., Shibata S., Zhang Z., Sun Z., Deng W., Ross J., Kim J., Xiao L.,
Arakaki T., Bosch J., Caruthers J.M., Larson E.T., LeTrong I., Napuli A., Kelly A., Mueller N.,
Zucker F., Van Voorhis W.C., Merritt E.A., Hol W.G.J. (2009). Fragment-based cocktail
crystallographyy
by the Medical Structural Genomics of Pathogenic Protozoa Consortium.
Curr. Topics Med. Chem., in press.
The 26 following researchers have been licensed: