/*
 COMMENTS: AG1522 normal human fibroblasts cells irradiated in plateau phase.

 REFERENCE:
  Hall EJ, Marchese MJ, Astor MB, and Morse T. Response of Cells of Human Origin,
  Normal and Malignant to Acute and Low Dose Rate Irradiation.
  Int. J. Radiat. Onc. Biol. Phys. 12, 655-659 (1986).
 

 PREPARED BY: Julien Partouche (julien@tamu.edu)
 DATE: 18-JUL-2003.

*/
  

MODEL: DRM=TLK CKM=QECK
CELL: DNA=5.667D+09 NC=46
IRAD: CL=DSB
CLRP: RHT=HT4R BMR=4.3976503E-04 PHI=PML A0=PMR
CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1
RBM: KX=6.0E+06 FMAX=1 !Analysis of PFGE data

! TLK model inputs (simple and complex double strand breaks)
DSB = 20 5 / !Radiation damage to DNA
HT4R = 8.6179242E-01 8.7735334E-01 / !Half-times for DSB repair
PML = 2.1429799E-02 / !Probability a misrejoined DSB is lethal
PMR = 0.75 0.25 / !Probability DSB is rejoined correctly

! Parameters that impact on solution accuracy
SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10

! Parameters that control the time steps and stopping criteria
SIMCON: FSDX=1 TSAX=12 TCUT=96 FRDL=1.0D+00 RCUT=1.0D-09

!IRRADIATION CONDITIONS (single fraction)
RADX: ADR=RX1 AD=RX2
RX1 = 0.24 0.34 0.71 81 / !dose rate (Gy/h)
RX2 = 0 0.1 0.25 0.5 1 1.5 2 3 4 5 6 7 8 9 10 12.5 15 17.5 20 25 30 35 /

Last updated: 10 June, 2011
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