Ron Stenkamp's Homepage - Crystallography and Molecules

Overview

I'm a professor in the Departments of Biological Structure and Biochemistry at the University of Washington. My research and teaching activities are centered on the structure and function of biological macromolecules with a strong dependence on X-ray crystallographic techniques for studying molecular structures. I particularly enjoy the mix of experimental and computational work associated with crystallography and the great dependence on geometry in this type of research.

Teaching Projects

Biological X-ray Structure Analysis - Biological Structure 515

This introductory course covers the fundamentals of crystals (lattices, unit cells, symmetry, space groups), diffraction (optical analogs, Laue conditions, Bragg's Law, Ewald's sphere of reflection), structure solution (direct methods, Patterson techniques, multiple isomorphous replacement, molecular replacement, MAD), and refinement. The course content and organization is being revised (2012), and the course website will be revised when possible.

Research Projects

My group collaborates with many others to provide crystal structures of molecules of biochemical interest. Listed here are proteins of past and present interest, along with links to websites describing some of the molecules and projects in more detail. Current and past collaborators are also listed here.

• G-Protein-Coupled Receptors
  Rhodopsin - co-investigators - Kris Palczewski, Dave Teller.
• Protein-Ligand Interactions
  Streptavidin - co-investigators - Pat Stayton, Terry Lybrand.
• Metalloproteins
  Hemerythrin
  Rubredoxin
• Drug Detoxication Enzymes
  Glutathione S-transferase - co-investigators - Bill Atkins, Michele Scian.
  Cytochrome P450 - co-investigators - Rheem Totah, Bill Atkins.
  
• Cell Adhesion Proteins
  Fimbria - co-investigators - Evgeni Sokurenko, Wendy Thomas.
  DraE - co-investigator - Steve Moseley, Natalia Korotkova.
  
• Transcription Regulators
  SlyA - co-investigators - Steve Libby, Peter Brzovic.
  
• Other Proteins and Peptides
  COMT - co-investigator - Bill Parson.
  BRCA1 - co-investigator - Rachel Klevit.
  Type VI Secretion System Proteins - co-investigator - Joseph Mougous.
  Aldehyde dehydrogenase - co-investigators - John Amory, Jisun Paik, Alex Goldstein, Nina Isoherranen.
  Trp cages - co-investigators - Niels Andersen, Michele Scian.
  Pectin methylesterase - co-investigators - Jerry Reeck, Dave Teller.
• Cellular Retinaldehyde-Binding Protein
  CRALBP - co-investigators - Jack Saari, Dave Teller, Ram Samudrala.
• Blood-Proteins (on hold)
  Factor XIII - co-investigators - Dave Teller, Earl Davie.

Publications

Contact Information

copyright © Ron Stenkamp Most recent update 12/30/2020