The mTOR team, led by recent PhD graduate and lab alum Devin Wehle, has published its second paper as a pre-print, available here. They’ve discovered that the mTOR protein interaction network behaves in a fundamentally different way in primary cultured neurons compared to immortalized cell lines in which mTOR is usually studied– mTOR activation (measured by phosphorylation) leads to widespread dis-association of mTOR protein complexes (measured by QMI). This surprising result will open a new (R01-funded) line of investigation into how the mTOR network conveys information in neurons- and how that information flow may be disrupted in neuropsychiatric disorders.